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Protein

Thymidine kinase

Gene

tdk

Organism
Streptococcus salivarius (strain CCHSS3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Proton acceptorUniRule annotation1
Metal bindingi143ZincUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi180ZincUniRule annotation1
Metal bindingi183ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi85 – 88ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciSSAL1048332:G1H40-887-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SALIVB_0835Imported
OrganismiStreptococcus salivarius (strain CCHSS3)Imported
Taxonomic identifieri1048332 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000508 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

F8LIF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLYFRYGT MNSGKSIEIL KVAYNYEEQG KPVVLLTSRL DNRDGVGYIS
60 70 80 90 100
SRIGMKRKAF PIGDDTDIFG YVAHMDPRPY CVLVDEAQFL TRANVYDLAR
110 120 130 140 150
IVDELDIPVM AFGLKNDFQN NLFEGSKYLL LLSDKIDEIK TICHYCSRKA
160 170 180 190
TMVLRMEDGK PVYEGAQVQI GGHESYISVC RRHWFNPPQE NIIPLNKA
Length:198
Mass (Da):22,642
Last modified:September 21, 2011 - v1
Checksum:i449A1572BD48D994
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR873481 Genomic DNA Translation: CCB93129.1
RefSeqiWP_013990444.1, NC_015760.1

Genome annotation databases

EnsemblBacteriaiCCB93129; CCB93129; SALIVB_0835
KEGGissr:SALIVB_0835
PATRICifig|347254.3.peg.747

Similar proteinsi

Entry informationi

Entry nameiF8LIF9_STREH
AccessioniPrimary (citable) accession number: F8LIF9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health