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F8LIF9

- F8LIF9_STREH

UniProt

F8LIF9 - F8LIF9_STREH

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Protein

Thymidine kinase

Gene

tdk

Organism
Streptococcus salivarius (strain CCHSS3)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptorUniRule annotation
Metal bindingi143 – 1431ZincUniRule annotation
Metal bindingi146 – 1461ZincUniRule annotation
Metal bindingi180 – 1801ZincUniRule annotation
Metal bindingi183 – 1831ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi85 – 884ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSSAL1048332:GI6B-832-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SALIVB_0835Imported
OrganismiStreptococcus salivarius (strain CCHSS3)Imported
Taxonomic identifieri1048332 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000508: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8LIF9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLYFRYGT MNSGKSIEIL KVAYNYEEQG KPVVLLTSRL DNRDGVGYIS
60 70 80 90 100
SRIGMKRKAF PIGDDTDIFG YVAHMDPRPY CVLVDEAQFL TRANVYDLAR
110 120 130 140 150
IVDELDIPVM AFGLKNDFQN NLFEGSKYLL LLSDKIDEIK TICHYCSRKA
160 170 180 190
TMVLRMEDGK PVYEGAQVQI GGHESYISVC RRHWFNPPQE NIIPLNKA
Length:198
Mass (Da):22,642
Last modified:September 21, 2011 - v1
Checksum:i449A1572BD48D994
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR873481 Genomic DNA. Translation: CCB93129.1.
RefSeqiWP_013990444.1. NC_015760.1.
YP_004727656.1. NC_015760.1.

Genome annotation databases

EnsemblBacteriaiCCB93129; CCB93129; SALIVB_0835.
GeneIDi10972662.
KEGGissr:SALIVB_0835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR873481 Genomic DNA. Translation: CCB93129.1 .
RefSeqi WP_013990444.1. NC_015760.1.
YP_004727656.1. NC_015760.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCB93129 ; CCB93129 ; SALIVB_0835 .
GeneIDi 10972662.
KEGGi ssr:SALIVB_0835.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci SSAL1048332:GI6B-832-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCHSS3Imported.

Entry informationi

Entry nameiF8LIF9_STREH
AccessioniPrimary (citable) accession number: F8LIF9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: October 29, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3