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F8LGT1 (F8LGT1_STREH) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase HAMAP-Rule MF_00049
EC=6.1.1.4 HAMAP-Rule MF_00049
Alternative name(s):
Leucyl-tRNA synthetase HAMAP-Rule MF_00049
Gene names
Name:leuS HAMAP-Rule MF_00049 EMBL CCB92551.1
Ordered Locus Names:SALIVB_0236 EMBL CCB92551.1
OrganismStreptococcus salivarius (strain CCHSS3) [Complete proteome] [HAMAP]
Taxonomic identifier1048332 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length833 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. RuleBase RU003489 HAMAP-Rule MF_00049

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Motif41 – 5212"HIGH" region By similarity HAMAP-Rule MF_00049
Motif610 – 6145"KMSKS" region By similarity HAMAP-Rule MF_00049

Sites

Binding site6131ATP By similarity HAMAP-Rule MF_00049

Sequences

Sequence LengthMass (Da)Tools
F8LGT1 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: A45D1BFC4268784A

FASTA83394,467
        10         20         30         40         50         60 
MSFYNHKEIE PKWQKYWADN HTFKTGTDAS KPKFYALDMF PYPSGAGLHV GHPEGYTATD 

        70         80         90        100        110        120 
ILSRFKRAQG YNVLHPMGWD AFGLPAEQYA MDTGNDPAEF TAENIANFKR QINALGFSYD 

       130        140        150        160        170        180 
WDREVNTTDP NYYKWTQWIF TKLYEKGLAY EAEVPVNWVE ELGTAIANEE VLPDGTSERG 

       190        200        210        220        230        240 
GYPVVRKPMR QWMLKITAYA ERLLNDLDEL DWPESIKDMQ RNWIGKSTGA NVTFKVKGTD 

       250        260        270        280        290        300 
KEFTVFTTRP DTLFGATFTV LAPEHDLVDA ITTPEQAEAV ADYKHQASLK SDLARTDLAK 

       310        320        330        340        350        360 
EKTGVWTGAY AINPVNGKEI PIWIADYVLA SYGTGAVMAV PAHDERDWEF AKQFDLPIVE 

       370        380        390        400        410        420 
VLEGGNVEEA AYTEDGLHVN SDFLNGLNKE EAIAKIVAWL EEKGCGQEKV TYRLRDWLFS 

       430        440        450        460        470        480 
RQRYWGEPIP IVHWEDGTST AVPESDLPLV LPVTKDIRPS GTGESPLANL TDWLEVTRED 

       490        500        510        520        530        540 
GVKGRRETNT MPQWAGSSWY YLRYIDPHNT EKLADEDLLK QWLPVDIYVG GAEHAVLHLL 

       550        560        570        580        590        600 
YARFWHKFLY DLGVVPTKEP FQKLFNQGMI LGTSYRDHRG ALVATDKVEK RDGSFFHMET 

       610        620        630        640        650        660 
GEELEQAPAK MSKSLKNVVN PDDVVEQYGA DTLRVYEMFM GPLDASIAWS EEGLEGSRKF 

       670        680        690        700        710        720 
LDRVYRLITT KEIVAENNGT LDKVYNETVK SVTEQVESMK FNTAIAQLMV FVNAANKEDK 

       730        740        750        760        770        780 
LYVDYAKGFI QLIAPFAPHL AEELWQTVAE TGESISYVAW PTWDESKLVE DEIEIVVQIK 

       790        800        810        820        830 
GKVRAKLMVA KDLSREELQE VALANEKVKA EIDGKEIVKV ISVPNKLVNI VVK

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References

[1]"Complete genome sequence of the clinical Streptococcus salivarius strain CCHSS3."
Delorme C., Guedon E., Pons N., Cruaud C., Couloux A., Loux V., Chiapello H., Poyart C., Gautier C., Sanchez N., Almeida M., Kennedy S.P., Ehrlich S.D., Gibrat J.F., Wincker P., Renault P.
J. Bacteriol. 193:5041-5042(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CCHSS3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FR873481 Genomic DNA. Translation: CCB92551.1.
RefSeqYP_004727078.1. NC_015760.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCB92551; CCB92551; SALIVB_0236.
GeneID10971512.
KEGGssr:SALIVB_0236.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01869.

Enzyme and pathway databases

BioCycSSAL1048332:GI6B-242-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. tRNAsyn_1a_bind. 1 hit.
SSF50677. ValRS_IleRS_edit. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8LGT1_STREH
AccessionPrimary (citable) accession number: F8LGT1
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: May 29, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info