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F8LFZ3 (F8LFZ3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:HLA-DQB1 EMBL CCB96521.1
OrganismHomo sapiens (Human) EMBL CCB96521.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length183 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS014745

Ontologies

Keywords
   Biological processImmunity
   Cellular componentMembrane
MHC II SAAS SAAS014745 RuleBase RU000321
   DomainTransmembrane
Transmembrane helix SAAS SAAS014745
Gene Ontology (GO)
   Biological_processB cell affinity maturation

Inferred from electronic annotation. Source: Ensembl

antigen processing and presentation of exogenous peptide antigen via MHC class II

Inferred from electronic annotation. Source: Ensembl

cellular response to interferon-gamma

Inferred from electronic annotation. Source: Ensembl

positive regulation of T-helper 1 type immune response

Inferred from electronic annotation. Source: Ensembl

positive regulation of alpha-beta T cell activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of antigen processing and presentation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

MHC class II protein complex

Inferred from electronic annotation. Source: UniProtKB-KW

early endosome

Inferred from electronic annotation. Source: Ensembl

external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

multivesicular body

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionpeptide antigen binding

Inferred from electronic annotation. Source: Ensembl

toxic substance binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL CCB96521.1
Non-terminal residue1831 EMBL CCB96521.1

Sequences

Sequence LengthMass (Da)Tools
F8LFZ3 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: DEC84511295DD463

FASTA18321,402
        10         20         30         40         50         60 
DFVFQFKGMC YFTNGTERVR LVTRYIYNRE EYARFDSDVG VYRAVTPQGR PDAEYWNSQK 

        70         80         90        100        110        120 
EVLEGTRAEL DTVCRHNYEV AFRGILQRRV EPTVTISPSR TEALNHHNLL VCSVTDFYPG 

       130        140        150        160        170        180 
QIKVRWFRND QEETAGVVST PLIRNGDWTF QILVMLEMTP QRGDVYTCHV EHPSLQSPIT 


VEW 

« Hide

References

[1]"Characterization of 700 novel alleles at the HLA-A, -B, C, DQB1 and - DRB1 loci from Chinese Marrow Donor Program volunteer donors."
Qu J., Huang C., Li J., Chen H., Zheng Z., Yi X., Yang L., Wang J.
Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FR873088 Genomic DNA. Translation: CCB96521.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Gene expression databases

ArrayExpressF8LFZ3.
BgeeF8LFZ3.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-DQB1. human.
NextBio35510615.

Entry information

Entry nameF8LFZ3_HUMAN
AccessionPrimary (citable) accession number: F8LFZ3
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 19, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.