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F8L6Q2

- F8L6Q2_SIMNZ

UniProt

F8L6Q2 - F8L6Q2_SIMNZ

Protein

Thymidine kinase

Gene

tdk

Organism
Simkania negevensis (strain ATCC VR-1471 / Z)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891Proton acceptorUniRule annotation
    Metal bindingi146 – 1461ZincUniRule annotation
    Metal bindingi148 – 1481ZincUniRule annotation
    Metal bindingi183 – 1831ZincUniRule annotation
    Metal bindingi186 – 1861ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi88 – 914ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

    Enzyme and pathway databases

    BioCyciSNEG331113:GHY3-535-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:SNE_A05230Imported
    OrganismiSimkania negevensis (strain ATCC VR-1471 / Z)Imported
    Taxonomic identifieri331113 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesSimkaniaceaeSimkania
    ProteomesiUP000000496: Chromosome gsn.131

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F8L6Q2-1 [UniParc]FASTAAdd to Basket

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    MAKLYFYYSA MNAGKSTTLL QSSYNYRERG MNTLLLAPRF DDRFGDPAIY    50
    SRIGLKQEAL LFEKGTNIYY QTEEKIDEIG ALHCVLIDEA HFLTKSQVAQ 100
    LVSITKKLHV PVLCYGLRSD FLGEPFEGSQ YLLTWADELV EIKTICHCGS 150
    KATMNMRIDE EGSPVSKGNQ VHIGGNESYL SVCMKHFVEA IDAIEEIAFG 200
    KTHSNRS 207
    Length:207
    Mass (Da):23,337
    Last modified:September 21, 2011 - v1
    Checksum:i129F33B13B8EC1FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR872582 Genomic DNA. Translation: CCB88400.1.
    RefSeqiYP_004670891.1. NC_015713.1.

    Genome annotation databases

    EnsemblBacteriaiCCB88400; CCB88400; SNE_A05230.
    GeneIDi10887164.
    KEGGisng:SNE_A05230.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR872582 Genomic DNA. Translation: CCB88400.1 .
    RefSeqi YP_004670891.1. NC_015713.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCB88400 ; CCB88400 ; SNE_A05230 .
    GeneIDi 10887164.
    KEGGi sng:SNE_A05230.

    Phylogenomic databases

    KOi K00857.

    Enzyme and pathway databases

    BioCyci SNEG331113:GHY3-535-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Unity in variety -- the pan-genome of the Chlamydiae."
      Collingro A., Tischler P., Weinmaier T., Penz T., Heinz E., Brunham R.C., Read T.D., Bavoil P.M., Sachse K., Kahane S., Friedman M.G., Rattei T., Myers G.S.A., Horn M.
      Mol. Biol. Evol. 0:0-0(2011)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Z.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1471 / ZImported.

    Entry informationi

    Entry nameiF8L6Q2_SIMNZ
    AccessioniPrimary (citable) accession number: F8L6Q2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3