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Protein

Thymidine kinase

Gene

tdk

Organism
Simkania negevensis (strain ATCC VR-1471 / Z)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi148ZincUniRule annotation1
Metal bindingi183ZincUniRule annotation1
Metal bindingi186ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SNE_A05230Imported
OrganismiSimkania negevensis (strain ATCC VR-1471 / Z)Imported
Taxonomic identifieri331113 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeParachlamydialesSimkaniaceaeSimkania
Proteomesi
  • UP000000496 Componenti: Chromosome gsn.131

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi331113.SNE_A05230

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

F8L6Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLYFYYSA MNAGKSTTLL QSSYNYRERG MNTLLLAPRF DDRFGDPAIY
60 70 80 90 100
SRIGLKQEAL LFEKGTNIYY QTEEKIDEIG ALHCVLIDEA HFLTKSQVAQ
110 120 130 140 150
LVSITKKLHV PVLCYGLRSD FLGEPFEGSQ YLLTWADELV EIKTICHCGS
160 170 180 190 200
KATMNMRIDE EGSPVSKGNQ VHIGGNESYL SVCMKHFVEA IDAIEEIAFG

KTHSNRS
Length:207
Mass (Da):23,337
Last modified:September 21, 2011 - v1
Checksum:i129F33B13B8EC1FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR872582 Genomic DNA Translation: CCB88400.1
RefSeqiWP_013942867.1, NC_015713.1

Genome annotation databases

EnsemblBacteriaiCCB88400; CCB88400; SNE_A05230
KEGGisng:SNE_A05230

Similar proteinsi

Entry informationi

Entry nameiF8L6Q2_SIMNZ
AccessioniPrimary (citable) accession number: F8L6Q2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 28, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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