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F8L6Q2

- F8L6Q2_SIMNZ

UniProt

F8L6Q2 - F8L6Q2_SIMNZ

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Protein

Thymidine kinase

Gene

tdk

Organism
Simkania negevensis (strain ATCC VR-1471 / Z)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptorUniRule annotation
Metal bindingi146 – 1461ZincUniRule annotation
Metal bindingi148 – 1481ZincUniRule annotation
Metal bindingi183 – 1831ZincUniRule annotation
Metal bindingi186 – 1861ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi88 – 914ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciSNEG331113:GHY3-535-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SNE_A05230Imported
OrganismiSimkania negevensis (strain ATCC VR-1471 / Z)Imported
Taxonomic identifieri331113 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesSimkaniaceaeSimkania
ProteomesiUP000000496: Chromosome gsn.131

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

F8L6Q2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKLYFYYSA MNAGKSTTLL QSSYNYRERG MNTLLLAPRF DDRFGDPAIY
60 70 80 90 100
SRIGLKQEAL LFEKGTNIYY QTEEKIDEIG ALHCVLIDEA HFLTKSQVAQ
110 120 130 140 150
LVSITKKLHV PVLCYGLRSD FLGEPFEGSQ YLLTWADELV EIKTICHCGS
160 170 180 190 200
KATMNMRIDE EGSPVSKGNQ VHIGGNESYL SVCMKHFVEA IDAIEEIAFG

KTHSNRS
Length:207
Mass (Da):23,337
Last modified:September 21, 2011 - v1
Checksum:i129F33B13B8EC1FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR872582 Genomic DNA. Translation: CCB88400.1.
RefSeqiWP_013942867.1. NC_015713.1.
YP_004670891.1. NC_015713.1.

Genome annotation databases

EnsemblBacteriaiCCB88400; CCB88400; SNE_A05230.
GeneIDi10887164.
KEGGisng:SNE_A05230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR872582 Genomic DNA. Translation: CCB88400.1 .
RefSeqi WP_013942867.1. NC_015713.1.
YP_004670891.1. NC_015713.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCB88400 ; CCB88400 ; SNE_A05230 .
GeneIDi 10887164.
KEGGi sng:SNE_A05230.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci SNEG331113:GHY3-535-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Unity in variety -- the pan-genome of the Chlamydiae."
    Collingro A., Tischler P., Weinmaier T., Penz T., Heinz E., Brunham R.C., Read T.D., Bavoil P.M., Sachse K., Kahane S., Friedman M.G., Rattei T., Myers G.S.A., Horn M.
    Mol. Biol. Evol. 0:0-0(2011)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Z.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1471 / ZImported.

Entry informationi

Entry nameiF8L6Q2_SIMNZ
AccessioniPrimary (citable) accession number: F8L6Q2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 26, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3