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Protein

Alanine racemase

Gene

dal

Organism
Staphylococcus lugdunensis (strain N920143)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei30 – 301Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei122 – 1221SubstrateUniRule annotation
Active sitei257 – 2571Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei304 – 3041Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSLUG1034809:GLKV-1542-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:dalImported
ORF Names:SLUG_14890Imported
OrganismiStaphylococcus lugdunensis (strain N920143)Imported
Taxonomic identifieri1034809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000011123: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF8KKZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.

Sequencei

Sequence statusi: Complete.

F8KKZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATWSVNSD IFFNNVVTVK NNQPIMAVVK NNAYHYGLEY AVNMFLKAGI
60 70 80 90 100
NTFSTTSLKE AVRIRKLAPK ATIFLMNAVY DFDIVRHNRI HMTLPSLQYY
110 120 130 140 150
YANKSNLYDI NVHLEYENLL HRSGFKNLSE LREVLKDHEQ NNQPHKMHIT
160 170 180 190 200
GLWTHFGYAD EFDVPEYDTE KRAWLKVLNT LLAEGYTFDM IHAQNSASFY
210 220 230 240 250
REQHQVLSNH THARVGIALY GSRPYSSLKP SEIKQALTVK ANVIQVREVN
260 270 280 290 300
KGDYCGYSFA YECKNHHTRL AVVDIGYGDG ILKSRAQHDV IINGKRYPIR
310 320 330 340 350
ALMMSHMFVE VDELVHARDE VVLYNNDIRI DEFTFKGVGA NSEQLSAMNH

DSLIKEYK
Length:358
Mass (Da):41,337
Last modified:September 21, 2011 - v1
Checksum:i3FFEB75E478AB135
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR870271 Genomic DNA. Translation: CCB53975.1.
RefSeqiWP_002478211.1. NC_017353.1.
YP_005760606.1. NC_017353.1.

Genome annotation databases

EnsemblBacteriaiCCB53975; CCB53975; SLUG_14890.
GeneIDi12426993.
KEGGisln:SLUG_14890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR870271 Genomic DNA. Translation: CCB53975.1.
RefSeqiWP_002478211.1. NC_017353.1.
YP_005760606.1. NC_017353.1.

3D structure databases

ProteinModelPortaliF8KKZ3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCB53975; CCB53975; SLUG_14890.
GeneIDi12426993.
KEGGisln:SLUG_14890.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciSLUG1034809:GLKV-1542-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors."
    Heilbronner S., Holden M.T., van Tonder A., Geoghegan J.A., Foster T.J., Parkhill J., Bentley S.D.
    FEMS Microbiol. Lett. 322:60-67(2011)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N920143Imported.

Entry informationi

Entry nameiF8KKZ3_STALN
AccessioniPrimary (citable) accession number: F8KKZ3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 4, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.