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F8K626

- F8K626_MYCL9

UniProt

F8K626 - F8K626_MYCL9

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Protein
Thymidine kinase
Gene
tdk, MLEA_003980
Organism
Mycoplasma leachii (strain 99/014/6)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041Proton acceptor By similarityUniRule annotation
Metal bindingi160 – 1601Zinc By similarityUniRule annotation
Metal bindingi163 – 1631Zinc By similarityUniRule annotation
Metal bindingi198 – 1981Zinc By similarityUniRule annotation
Metal bindingi201 – 2011Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi25 – 328ATP By similarityUniRule annotation
Nucleotide bindingi103 – 1064ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciMLEA866629:GLHJ-398-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:MLEA_003980Imported
OrganismiMycoplasma leachii (strain 99/014/6)
Taxonomic identifieri866629 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000295: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00857.
OMAiQAICLSC.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8K626-1 [UniParc]FASTAAdd to Basket

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MIELDINEIE AYNSNKMGWI ELITGCMFAG KTEEFIRRLK VLSYAKKRVL    50
AFKPSIDNRY SVENIISHSG SKLDSYLVKS SDEIKQIVEK ENQIQQVDVI 100
GIDEVQFFDE NVVDIVEQLA DNGIIVIVNG LDKDFRGLPF KNVDKLLVKA 150
EFVTKLRARC HLCGSFANRS QRIVNGQPAL WNSPLILVDG KESYEARCRK 200
CFIAPKKDV 209
Length:209
Mass (Da):23,802
Last modified:September 21, 2011 - v1
Checksum:i0E65FD0FECD1BB2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR668087 Genomic DNA. Translation: CBV67127.1.
RefSeqiYP_005907312.1. NC_017521.1.

Genome annotation databases

EnsemblBacteriaiCBV67127; CBV67127; MLEA_003980.
GeneIDi13113443.
KEGGimlh:MLEA_003980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR668087 Genomic DNA. Translation: CBV67127.1 .
RefSeqi YP_005907312.1. NC_017521.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBV67127 ; CBV67127 ; MLEA_003980 .
GeneIDi 13113443.
KEGGi mlh:MLEA_003980.

Phylogenomic databases

KOi K00857.
OMAi QAICLSC.

Enzyme and pathway databases

BioCyci MLEA866629:GLHJ-398-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics analysis of Mycoplasma leachii reveals genes involved in host specificities."
    Rodriguez-Chamorro A., Calderon-Copete S.P., Vilei E.M., Djordjevic S., Frey J., Falquet L.
    Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 99/014/6Imported.

Entry informationi

Entry nameiF8K626_MYCL9
AccessioniPrimary (citable) accession number: F8K626
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 11, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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