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F8JVS3

- F8JVS3_STREN

UniProt

F8JVS3 - F8JVS3_STREN

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Protein

Thymidine kinase

Gene

tdk

Organism
Streptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi86 – 894ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSCAT1003195:GJCM-4660-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SCAT_4622Imported, SCATT_46130Imported
OrganismiStreptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057)Imported
Taxonomic identifieri1003195 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000007842: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

F8JVS3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSELVYFCGT MDCGKSTLAL QIEHNRSARG LHGMIFTRND RAGTGVLSSR
60 70 80 90 100
LGLSTKAVEA GDDLDFYVHV VDHLSGGGRV DYVIADEAQF FTPEQVDQLA
110 120 130 140 150
RVVDDLGLDV YAFGITTDFR TRLFPGSARL VELADRIEVL QVEALCWCGA
160 170 180 190 200
RATHNARTVD GRMVVEGAQV VVGDVNGSAG EVGYEVLCRR HHTRRMTAAT
210 220
ARAAALSPDV LPVDTPAARA MEPVPDA
Length:227
Mass (Da):24,492
Last modified:September 21, 2011 - v1
Checksum:iC55A8602714EEAE8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003219 Genomic DNA. Translation: AEW96984.1.
FQ859185 Genomic DNA. Translation: CCB77310.1.
RefSeqiYP_004914113.1. NC_016111.1.
YP_006056506.1. NC_017586.1.

Genome annotation databases

EnsemblBacteriaiAEW96984; AEW96984; SCATT_46130.
CCB77310; CCB77310; SCAT_4622.
GeneIDi11358840.
12651383.
KEGGisct:SCAT_4622.
scy:SCATT_46130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003219 Genomic DNA. Translation: AEW96984.1 .
FQ859185 Genomic DNA. Translation: CCB77310.1 .
RefSeqi YP_004914113.1. NC_016111.1.
YP_006056506.1. NC_017586.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEW96984 ; AEW96984 ; SCATT_46130 .
CCB77310 ; CCB77310 ; SCAT_4622 .
GeneIDi 11358840.
12651383.
KEGGi sct:SCAT_4622.
scy:SCATT_46130.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci SCAT1003195:GJCM-4660-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites."
    Barbe V., Bouzon M., Mangenot S., Badet B., Poulain J., Segurens B., Vallenet D., Marliere P., Weissenbach J.
    J. Bacteriol. 193:5055-5056(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NRRL 8057Imported.
  2. Genoscope - CEA
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NRRL 8057Imported.
  3. "Complete genome sequence of Streptomyces cattleya strain DSM 46488."
    Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.
    Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057Imported.
  4. Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.
    Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 46488Imported.

Entry informationi

Entry nameiF8JVS3_STREN
AccessioniPrimary (citable) accession number: F8JVS3
Secondary accession number(s): G8X3D3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3