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F8JVS3

- F8JVS3_STREN

UniProt

F8JVS3 - F8JVS3_STREN

Protein

Thymidine kinase

Gene

tdk

Organism
Streptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei87 – 871Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi86 – 894ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSCAT1003195:GJCM-4660-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:SCAT_4622Imported, SCATT_46130Imported
    OrganismiStreptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057)Imported
    Taxonomic identifieri1003195 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000007842: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F8JVS3-1 [UniParc]FASTAAdd to Basket

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    MSELVYFCGT MDCGKSTLAL QIEHNRSARG LHGMIFTRND RAGTGVLSSR    50
    LGLSTKAVEA GDDLDFYVHV VDHLSGGGRV DYVIADEAQF FTPEQVDQLA 100
    RVVDDLGLDV YAFGITTDFR TRLFPGSARL VELADRIEVL QVEALCWCGA 150
    RATHNARTVD GRMVVEGAQV VVGDVNGSAG EVGYEVLCRR HHTRRMTAAT 200
    ARAAALSPDV LPVDTPAARA MEPVPDA 227
    Length:227
    Mass (Da):24,492
    Last modified:September 21, 2011 - v1
    Checksum:iC55A8602714EEAE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003219 Genomic DNA. Translation: AEW96984.1.
    FQ859185 Genomic DNA. Translation: CCB77310.1.
    RefSeqiWP_014145326.1. NC_017586.1.
    YP_004914113.1. NC_016111.1.
    YP_006056506.1. NC_017586.1.

    Genome annotation databases

    EnsemblBacteriaiAEW96984; AEW96984; SCATT_46130.
    CCB77310; CCB77310; SCAT_4622.
    GeneIDi11358840.
    12651383.
    KEGGisct:SCAT_4622.
    scy:SCATT_46130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003219 Genomic DNA. Translation: AEW96984.1 .
    FQ859185 Genomic DNA. Translation: CCB77310.1 .
    RefSeqi WP_014145326.1. NC_017586.1.
    YP_004914113.1. NC_016111.1.
    YP_006056506.1. NC_017586.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEW96984 ; AEW96984 ; SCATT_46130 .
    CCB77310 ; CCB77310 ; SCAT_4622 .
    GeneIDi 11358840.
    12651383.
    KEGGi sct:SCAT_4622.
    scy:SCATT_46130.

    Phylogenomic databases

    KOi K00857.

    Enzyme and pathway databases

    BioCyci SCAT1003195:GJCM-4660-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites."
      Barbe V., Bouzon M., Mangenot S., Badet B., Poulain J., Segurens B., Vallenet D., Marliere P., Weissenbach J.
      J. Bacteriol. 193:5055-5056(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NRRL 8057Imported.
    2. Genoscope - CEA
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NRRL 8057Imported.
    3. "Complete genome sequence of Streptomyces cattleya strain DSM 46488."
      Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.
      Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057Imported.
    4. Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.
      Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSM 46488Imported.

    Entry informationi

    Entry nameiF8JVS3_STREN
    AccessioniPrimary (citable) accession number: F8JVS3
    Secondary accession number(s): G8X3D3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3