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F8JVJ1 (F8JVJ1_STREN) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Sequences

Sequence LengthMass (Da)Tools
F8JVJ1 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: B3E49DBE3FC3CBFF

FASTA40342,215
        10         20         30         40         50         60 
MSETTTPATA AALDDRAAAL DAADPLAALR ERFVLDDTVY LDGNSLGALP KNVAGRLAEV 

        70         80         90        100        110        120 
VEDEWGRLRI RSWDESGWWT APERVGERIA PLVGAAPGQI VVGDSTSVNV FKAVVAATRL 

       130        140        150        160        170        180 
AGPGRDEVLV DAATFPTDGY VAASAARLTG HTVRPVAAGE MAAAAGARTA ALLVNHVDYR 

       190        200        210        220        230        240 
TGELADLPGI TAAAHAAGAV AVWDLCHSAG ALPVGLDEHG VDLAVGCTYK YLNGGPGAPA 

       250        260        270        280        290        300 
FLYLARRIQD RFDSPLPGWN SHTDPFAMRP GYEAAPGAVR GRVGTPEILS LLALEAALEV 

       310        320        330        340        350        360 
WEGVDVAQVR AKSLALTDFF LECVAALVPD GRLEPVTPAE HARRGSQVSL RCADAGAVMA 

       370        380        390        400 
ALIERGVVGD FRRPDVLRFG FTPLYTGFAD VLRAARVLAD TVR

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites."
Barbe V., Bouzon M., Mangenot S., Badet B., Poulain J., Segurens B., Vallenet D., Marliere P., Weissenbach J.
J. Bacteriol. 193:5055-5056(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057 and NRRL 8057 EMBL CCB76028.1.
[2]Genoscope - CEA
Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NRRL 8057 EMBL CCB76028.1.
[3]"Complete genome sequence of Streptomyces cattleya strain DSM 46488."
Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.
Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057.
[4]Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.
Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: DSM 46488 EMBL AEW95690.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003219 Genomic DNA. Translation: AEW95690.1.
FQ859185 Genomic DNA. Translation: CCB76028.1.
RefSeqYP_004912833.1. NC_016111.1.
YP_006055212.1. NC_017586.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEW95690; AEW95690; SCATT_33190.
CCB76028; CCB76028; SCAT_3326.
GeneID11358482.
12650089.
KEGGsct:SCAT_3326.
scy:SCATT_33190.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01556.

Enzyme and pathway databases

BioCycSCAT1003195:GJCM-3349-MONOMER.
UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameF8JVJ1_STREN
AccessionPrimary (citable) accession number: F8JVJ1
Secondary accession number(s): G8WQT1
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 3, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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