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F8JU34

- F8JU34_STREN

UniProt

F8JU34 - F8JU34_STREN

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Protein
Probable DNA ligase
Gene
lig, SCAT_0666
Organism
Streptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei208 – 2081ATP By similarityUniRule annotation
Active sitei210 – 2101N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei215 – 2151ATP By similarityUniRule annotation
Binding sitei230 – 2301ATP By similarityUniRule annotation
Binding sitei259 – 2591ATP By similarityUniRule annotation
Binding sitei299 – 2991ATP By similarityUniRule annotation
Binding sitei377 – 3771ATP By similarityUniRule annotation
Binding sitei383 – 3831ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSCAT1003195:GJCM-668-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotationImported
Ordered Locus Names:SCAT_0666Imported
OrganismiStreptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057)Imported
Taxonomic identifieri1003195 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000006623: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK01971.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8JU34-1 [UniParc]FASTAAdd to Basket

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MRFVEVARTS REVAATSARS RKISLLSGLF RDAEPSEAPV VITYLAGRLP    50
QRRIGVGWST LSEPVPAAEE PRLAVLEVHL ALGRIASVVG QGAQHERRRL 100
VHELLAAATE EEQRFLVALI AGELRQGALD ALAVEGLAAA VGVGAGDVRR 150
AVMLRGSLGA VAEALLARGA EALTDFRLEV GRPVLPMLAH TARDVAEALD 200
RLGPCAVEEK LDGIRVQVHR DGDLVRVYTR SLDEITDRLP EVVAEARALP 250
GRQAVLDGEV IALGEDGRPR AFQETAGRVG SRLDVASAQA ALPVFPVFFD 300
LLYVDGRDLL ELSTADRHAE LAALVPVPLR VRRIVAEDPG SPADRAAAEE 350
FTEATLARGH EGVVLKALDA PYSAGRRGAS WLKVKPVHTL DLVVLAAEWG 400
HGRRTGKLSN LHLGARRRNG TFAMLGKTFK GLTDAMLEWQ TERLQELTVH 450
DERWGVVVRP ELVVEVAFDG VQRSPRYPEG VTLRFARVLR YREDKTPDQA 500
DTVETVLGLR APAAPAP 517
Length:517
Mass (Da):55,999
Last modified:September 21, 2011 - v1
Checksum:iCF33E3A1A3BF01F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ859185 Genomic DNA. Translation: CCB73404.1.
RefSeqiWP_014141442.1. NC_016111.1.
YP_004910211.1. NC_016111.1.

Genome annotation databases

EnsemblBacteriaiCCB73404; CCB73404; SCAT_0666.
GeneIDi11356814.
KEGGisct:SCAT_0666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ859185 Genomic DNA. Translation: CCB73404.1 .
RefSeqi WP_014141442.1. NC_016111.1.
YP_004910211.1. NC_016111.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCB73404 ; CCB73404 ; SCAT_0666 .
GeneIDi 11356814.
KEGGi sct:SCAT_0666.

Phylogenomic databases

KOi K01971.

Enzyme and pathway databases

BioCyci SCAT1003195:GJCM-668-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites."
    Barbe V., Bouzon M., Mangenot S., Badet B., Poulain J., Segurens B., Vallenet D., Marliere P., Weissenbach J.
    J. Bacteriol. 193:5055-5056(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057.

Entry informationi

Entry nameiF8JU34_STREN
AccessioniPrimary (citable) accession number: F8JU34
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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