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F8JPP0 (F8JPP0_STREN) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase HAMAP-Rule MF_00834
EC=2.6.1.62 HAMAP-Rule MF_00834
Alternative name(s):
7,8-diamino-pelargonic acid aminotransferase HAMAP-Rule MF_00834
7,8-diaminononanoate synthase HAMAP-Rule MF_00834
Diaminopelargonic acid synthase HAMAP-Rule MF_00834
Gene names
Name:bioA HAMAP-Rule MF_00834 EMBL CCB73086.1
Ordered Locus Names:SCAT_0348 EMBL CCB73086.1, SCATT_03610 EMBL AEW92732.1
OrganismStreptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057) [Complete proteome] [HAMAP]
Taxonomic identifier1003195 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces ›

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor By similarity. HAMAP-Rule MF_00834

Catalytic activity

S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate. HAMAP-Rule MF_00834

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00834

Pathway

Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1. HAMAP-Rule MF_00834

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00834

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00834.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. HAMAP-Rule MF_00834

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region121 – 1222Pyridoxal phosphate binding By similarity HAMAP-Rule MF_00834
Region318 – 3192Pyridoxal phosphate binding By similarity HAMAP-Rule MF_00834

Sites

Binding site611Substrate By similarity HAMAP-Rule MF_00834
Binding site1541Substrate By similarity HAMAP-Rule MF_00834
Binding site2551Pyridoxal phosphate By similarity HAMAP-Rule MF_00834
Binding site2841Substrate By similarity HAMAP-Rule MF_00834
Binding site3171Substrate; via carbonyl oxygen By similarity HAMAP-Rule MF_00834
Binding site4011Substrate By similarity HAMAP-Rule MF_00834
Site221Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM By similarity HAMAP-Rule MF_00834

Amino acid modifications

Modified residue2841N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_00834

Sequences

Sequence LengthMass (Da)Tools
F8JPP0 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 506F56C8E40A9170

FASTA43446,202
        10         20         30         40         50         60 
MREADGVREL LRLDRAHVWH PYGPMPGREE PLVVESAAGV RLRVAALDGG RTELVDGMSS 

        70         80         90        100        110        120 
WWSAIHGYNH PVLNEAARGQ LERMSHVMFG GLTHEPAVRL ATRLVEITPE PLRHVFLADS 

       130        140        150        160        170        180 
GSVSVEVAVK MCLQYWRSVG RPAKRRLLTW RGGYHGDTWQ PMSVCDPDGG MHHLWSGLLP 

       190        200        210        220        230        240 
AQVFADAPPG GFADEPDPGY RDHLRDLIAR DADELAAVVV EPVVQGAGGM RFHSPGYLRV 

       250        260        270        280        290        300 
LREACDEHDV LLVLDEIATG FGRTGALFAA GHAGVAPDVM CVGKALTGGY LTLAATLCTS 

       310        320        330        340        350        360 
RVAEGISGGA VPVLAHGPTF MGNPLAAAVA GASIDLLLGQ DWAGEVRRIE SGLRAGLAPA 

       370        380        390        400        410        420 
AALPGVRDVR VLGAIGVVQL DHDVDVAAAT RAAVRAGVWL RPFRDLIYTM PPYVTGDDDV 

       430 
ARICAAVLAA AREG

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites."
Barbe V., Bouzon M., Mangenot S., Badet B., Poulain J., Segurens B., Vallenet D., Marliere P., Weissenbach J.
J. Bacteriol. 193:5055-5056(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057 and NRRL 8057 EMBL CCB73086.1.
[2]Genoscope - CEA
Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NRRL 8057 EMBL CCB73086.1.
[3]"Complete genome sequence of Streptomyces cattleya strain DSM 46488."
Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.
Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057.
[4]Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.
Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: DSM 46488 EMBL AEW92732.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003219 Genomic DNA. Translation: AEW92732.1.
FQ859185 Genomic DNA. Translation: CCB73086.1.
RefSeqYP_004909893.1. NC_016111.1.
YP_006052254.1. NC_017586.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEW92732; AEW92732; SCATT_03610.
CCB73086; CCB73086; SCAT_0348.
GeneID11357642.
12647131.
KEGGsct:SCAT_0348.
scy:SCATT_03610.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00833.

Enzyme and pathway databases

BioCycSCAT1003195:GJCM-350-MONOMER.
UniPathwayUPA00078; UER00160.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPMF_00834. BioA.
InterProIPR005814. Aminotrans_3.
IPR005815. BioA.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF8. PTHR11986:SF8. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR00508. bioA. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8JPP0_STREN
AccessionPrimary (citable) accession number: F8JPP0
Secondary accession number(s): G8WN13
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 3, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info