F8JJ69 (F8JJ69_STREN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase EMBL AEW98827.1

Submitted name:
Isocitrate dehydrogenase [NADP] EMBL CCB72125.1
EC=1.1.1.42 EMBL CCB72125.1

Gene names

Name:	icd EMBL CCB72125.1
Ordered Locus Names:	SCAT_p1101 EMBL CCB72125.1, SCATT_p06340 EMBL AEW98827.1

Encoded on

Plasmid pSCAT Ref.1 Ref.2 EMBL CCB72125.1
Plasmid pSCATT Ref.3 Ref.4 EMBL AEW98827.1

Organism

Streptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057) [Complete proteome] [HAMAP]

Taxonomic identifier

1003195 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces › Streptomyces cattleya

Protein attributes

Sequence length	739 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Molecular function	Oxidoreductase EMBL CCB72125.1
Technical term	Complete proteome Plasmid EMBL CCB72125.1
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	132 – 139	8	Substrate binding By similarity
Sites
	Metal binding	348	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	546	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	550	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	145	1	Substrate By similarity
	Binding site	545	1	Substrate By similarity
	Site	255	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	418	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	F8JJ69 [UniParc]. Last modified September 21, 2011. Version 1. Checksum: 7B3C32C5E0D4769C	FASTA	739	79,673
	10 20 30 40 50 60 MTDSTIIYTH TDEAPALATY SFLPVVEAYA SKAGVTVETR DISLAGRILA VFPEYLEEGQ 70 80 90 100 110 120 RIDDALAELG ELAKTPGANI IKLPNISASI PQLKAAVAEL REQGYALPEY PDDPKTDEER 130 140 150 160 170 180 EIRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKTHPH RMGAWTADSK TNVAHMTGDD 190 200 210 220 230 240 FRSTEKSAVV AEAGSLRIEL AGDDGTTTVL RESVPVLAGE VVDASVMRVA ALREFLAAQV 250 260 270 280 290 300 ARAKAEGVLF SVHLKATMMK VSDPIVFGHV VRAFFPKTFA KYGEVLASAG LTPNDGLGGI 310 320 330 340 350 360 FKGLEGLPEG AEIKASFDAE LGEGPALAMV DSDRGITNLH VPSDVIVDAS MPAMIRTSGH 370 380 390 400 410 420 MWGPDGKEAD TLAVLPDSSY AGVYQAVIDD CRANGAFDPA TMGSVPNVGL MAQKAEEYGS 430 440 450 460 470 480 HDKTFEIPTT GTVRVVDEAG EVVLQQTVSA GDIFRMCQTK DLPVRDWVKL AVTRARATGD 490 500 510 520 530 540 PAVFWLDETR AHDAQLITKV EAYLAEHDTE GLDIRVMSPV EATKFSLERI RRGENTISVT 550 560 570 580 590 600 GNVLRDYLTD LFPILELGTS AKMLSIVPLM AGGGLFETGA GGSAPKHVQQ LVKENYLRWD 610 620 630 640 650 660 SLGEFFALVP SLEQYAKTTG NTRAQVLADT LDRATATFLD EDKSPTRRIG GIDNRGSHFY 670 680 690 700 710 720 LAMYWAQELA RQTEDAQLAE AFADLARTLT EQESTIVDEL NAVQGEPADI GGYYKPDPAK 730 AAAVMRPSET FNRAIASLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites." Barbe V., Bouzon M., Mangenot S., Badet B., Poulain J., Segurens B., Vallenet D., Marliere P., Weissenbach J. J. Bacteriol. 193:5055-5056(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057 and NRRL 8057 EMBL CCB72125.1.
[2]	Genoscope - CEA Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: NRRL 8057 EMBL CCB72125.1.
[3]	"Complete genome sequence of Streptomyces cattleya strain DSM 46488." Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z. Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057.
[4]	Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z. Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: DSM 46488 EMBL AEW98827.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP003229 Genomic DNA. Translation: AEW98827.1. FQ859184 Genomic DNA. Translation: CCB72125.1.
RefSeq	YP_004920391.1. NC_016113.1. YP_006050780.1. NC_017585.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEW98827; AEW98827; SCATT_p06340. CCB72125; CCB72125; SCAT_p1101.
GeneID	11364637. 12645654.
KEGG	sct:SCAT_p1101. scy:SCATT_p06340.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00031.
Enzyme and pathway databases
BioCyc	SCAT1003195:GJCM-6970-MONOMER.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

F8JJ69_STREN

Accession

Primary (citable) accession number: F8JJ69
Secondary accession number(s): G8XH81

Entry history

Integrated into UniProtKB/TrEMBL:	September 21, 2011
Last sequence update:	September 21, 2011
Last modified:	April 3, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)