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F8JJ69

- F8JJ69_STREN

UniProt

F8JJ69 - F8JJ69_STREN

Protein
Submitted name:

Isocitrate dehydrogenase

Gene

icd

Organism
Streptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei145 – 1451SubstrateUniRule annotation
    Sitei255 – 2551Critical for catalysisUniRule annotation
    Metal bindingi348 – 3481Magnesium or manganeseUniRule annotation
    Sitei418 – 4181Critical for catalysisUniRule annotation
    Binding sitei545 – 5451Substrate
    Metal bindingi546 – 5461Magnesium or manganeseUniRule annotation
    Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciSCAT1003195:GJCM-6970-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenaseImported
    Submitted name:
    Isocitrate dehydrogenase [NADP]Imported (EC:1.1.1.42Imported)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:SCAT_p1101Imported, SCATT_p06340Imported
    Encoded oniPlasmid pSCATImported
    Plasmid pSCATTImported
    OrganismiStreptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057)Imported
    Taxonomic identifieri1003195 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000007842: Plasmid pSCATT

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni132 – 1398Substrate binding

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F8JJ69-1 [UniParc]FASTAAdd to Basket

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    MTDSTIIYTH TDEAPALATY SFLPVVEAYA SKAGVTVETR DISLAGRILA    50
    VFPEYLEEGQ RIDDALAELG ELAKTPGANI IKLPNISASI PQLKAAVAEL 100
    REQGYALPEY PDDPKTDEER EIRARYDKVK GSAVNPVLRE GNSDRRAPAS 150
    VKNYAKTHPH RMGAWTADSK TNVAHMTGDD FRSTEKSAVV AEAGSLRIEL 200
    AGDDGTTTVL RESVPVLAGE VVDASVMRVA ALREFLAAQV ARAKAEGVLF 250
    SVHLKATMMK VSDPIVFGHV VRAFFPKTFA KYGEVLASAG LTPNDGLGGI 300
    FKGLEGLPEG AEIKASFDAE LGEGPALAMV DSDRGITNLH VPSDVIVDAS 350
    MPAMIRTSGH MWGPDGKEAD TLAVLPDSSY AGVYQAVIDD CRANGAFDPA 400
    TMGSVPNVGL MAQKAEEYGS HDKTFEIPTT GTVRVVDEAG EVVLQQTVSA 450
    GDIFRMCQTK DLPVRDWVKL AVTRARATGD PAVFWLDETR AHDAQLITKV 500
    EAYLAEHDTE GLDIRVMSPV EATKFSLERI RRGENTISVT GNVLRDYLTD 550
    LFPILELGTS AKMLSIVPLM AGGGLFETGA GGSAPKHVQQ LVKENYLRWD 600
    SLGEFFALVP SLEQYAKTTG NTRAQVLADT LDRATATFLD EDKSPTRRIG 650
    GIDNRGSHFY LAMYWAQELA RQTEDAQLAE AFADLARTLT EQESTIVDEL 700
    NAVQGEPADI GGYYKPDPAK AAAVMRPSET FNRAIASLS 739
    Length:739
    Mass (Da):79,673
    Last modified:September 21, 2011 - v1
    Checksum:i7B3C32C5E0D4769C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003229 Genomic DNA. Translation: AEW98827.1.
    FQ859184 Genomic DNA. Translation: CCB72125.1.
    RefSeqiWP_014151550.1. NC_017585.1.
    YP_004920391.1. NC_016113.1.
    YP_006050780.1. NC_017585.1.

    Genome annotation databases

    EnsemblBacteriaiAEW98827; AEW98827; SCATT_p06340.
    CCB72125; CCB72125; SCAT_p1101.
    GeneIDi11364637.
    12645654.
    KEGGisct:SCAT_p1101.
    scy:SCATT_p06340.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003229 Genomic DNA. Translation: AEW98827.1 .
    FQ859184 Genomic DNA. Translation: CCB72125.1 .
    RefSeqi WP_014151550.1. NC_017585.1.
    YP_004920391.1. NC_016113.1.
    YP_006050780.1. NC_017585.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEW98827 ; AEW98827 ; SCATT_p06340 .
    CCB72125 ; CCB72125 ; SCAT_p1101 .
    GeneIDi 11364637.
    12645654.
    KEGGi sct:SCAT_p1101.
    scy:SCATT_p06340.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci SCAT1003195:GJCM-6970-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites."
      Barbe V., Bouzon M., Mangenot S., Badet B., Poulain J., Segurens B., Vallenet D., Marliere P., Weissenbach J.
      J. Bacteriol. 193:5055-5056(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NRRL 8057Imported.
      Plasmid: pSCAT
    2. Genoscope - CEA
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NRRL 8057Imported.
      Plasmid: pSCAT
    3. "Complete genome sequence of Streptomyces cattleya strain DSM 46488."
      Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.
      Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057Imported.
    4. Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.
      Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSM 46488Imported.
      Plasmid: pSCATT

    Entry informationi

    Entry nameiF8JJ69_STREN
    AccessioniPrimary (citable) accession number: F8JJ69
    Secondary accession number(s): G8XH81
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, PlasmidImported, Reference proteomeImported

    External Data

    Dasty 3