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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Hyphomicrobium sp. (strain MC1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotationSAAS annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonucleaseUniRule annotationSAAS annotationImported, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotationImported
Ordered Locus Names:HYPMC_3829Imported
OrganismiHyphomicrobium sp. (strain MC1)Imported
Taxonomic identifieri717785 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaeHyphomicrobium
Proteomesi
  • UP000000494 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi717785.HYPMC_3829

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 156tRNA_anti_2InterPro annotationAdd BLAST94
Domaini180 – 497Exonuc_VII_LInterPro annotationAdd BLAST318

Sequence similaritiesi

Belongs to the XseA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DVS Bacteria
COG1570 LUCA
KOiK03601
OMAiNARRRWP
OrthoDBiPOG091H02EK

Family and domain databases

CDDicd04489 ExoVII_LU_OBF, 1 hit
HAMAPiMF_00378 Exonuc_7_L, 1 hit
InterProiView protein in InterPro
IPR003753 Exonuc_VII_L
IPR020579 Exonuc_VII_lsu_C
IPR025824 OB-fold_nuc-bd_dom
PANTHERiPTHR30008 PTHR30008, 1 hit
PfamiView protein in Pfam
PF02601 Exonuc_VII_L, 1 hit
PF13742 tRNA_anti_2, 1 hit
TIGRFAMsiTIGR00237 xseA, 1 hit

Sequencei

Sequence statusi: Complete.

F8JIN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAAAGAEKK DIHQVACCNP VVSVASPCSI GGETSKTAKE NGKLLNSIPN
60 70 80 90 100
TRESRSGANA PEFSVSELSG AIKRALEEGF GYVRLRGEIS GYRGPHASGH
110 120 130 140 150
CYFALKDDKA KIEAVVWKGT FGRLRFKPEE GMEVVAQGKI TTFPGSSKYQ
160 170 180 190 200
IVIEALEPAG AGALMALLEE RKRKFAAEGL FDEDRKRPRP FLPKIVGIVT
210 220 230 240 250
SPTGAVIRDM LHGFNERFPT RVLLWPVRVQ GEGSAAEVAA AIRGFNALEA
260 270 280 290 300
DGTIPRPDVL IVARGGGSLE DLWSFNEEIV VRAVAESTIS LISAVGHETD
310 320 330 340 350
WTLIDLVADA RAPTPTKAAE WAVPKYSELI ENVEKLMLRK RTAVRRAIES
360 370 380 390 400
ARTHLKASAR GLPKLQDLVA LPRQRFDAAD RRLSRALLAN TRAHATRLAR
410 420 430 440 450
VSGRLSPAPI VQKHSRCAER LDGLERRAGR ALLNRVAVSR RVLEGRAALL
460 470 480 490 500
KSLGYQSVLS RGFALVRNEA GHMVRQAASL VAGDVLNIEF SDGRVGATVN
510 520 530
GSDVSSATPD VSNPTSSKVK TPRQKSSGRG GQGSLF
Length:536
Mass (Da):57,739
Last modified:September 21, 2011 - v1
Checksum:i698D4A69845AA249
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ859181 Genomic DNA Translation: CCB67039.1

Genome annotation databases

EnsemblBacteriaiCCB67039; CCB67039; HYPMC_3829
KEGGihmc:HYPMC_3829

Similar proteinsi

Entry informationi

Entry nameiF8JIN6_HYPSM
AccessioniPrimary (citable) accession number: F8JIN6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health