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F8JIN6

- F8JIN6_HYPSM

UniProt

F8JIN6 - F8JIN6_HYPSM

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Protein
Exodeoxyribonuclease 7 large subunit
Gene
xseA, HYPMC_3829
Organism
Hyphomicrobium sp. (strain MC1)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation
Exonucleolytic cleavage in either 5'- to 3'-or 3'- to 5'-direction to yield nucleoside 5'-phosphates.SAAS annotations

GO - Molecular functioni

  1. exodeoxyribonuclease VII activity Source: UniProtKB-HAMAP
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    ExonucleaseUniRule annotationSAAS annotationsImported, Hydrolase, Nuclease

    Enzyme and pathway databases

    BioCyciHSP717785:GJ7O-3837-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
    Alternative name(s):
    Exodeoxyribonuclease VII large subunit
    Gene namesi
    Name:xseAUniRule annotationImported
    Ordered Locus Names:HYPMC_3829Imported
    OrganismiHyphomicrobium sp. (strain MC1)Imported
    Taxonomic identifieri717785 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaeHyphomicrobium
    ProteomesiUP000000494: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotationSAAS annotations

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. exodeoxyribonuclease VII complex Source: InterPro
    Complete GO annotation...

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotations

    Interactioni

    Subunit structurei

    Heterooligomer composed of large and small subunits By similarity.UniRule annotationSAAS annotations

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the XseA family.UniRule annotation

    Phylogenomic databases

    KOiK03601.

    Family and domain databases

    HAMAPiMF_00378. Exonuc_7_L.
    InterProiIPR003753. Exonuc_VII_L.
    IPR020579. Exonuc_VII_lsu_C.
    IPR025824. OB-fold_nuc-bd_dom.
    [Graphical view]
    PfamiPF02601. Exonuc_VII_L. 1 hit.
    PF13742. tRNA_anti_2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00237. xseA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F8JIN6-1 [UniParc]FASTAAdd to Basket

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    MLAAAGAEKK DIHQVACCNP VVSVASPCSI GGETSKTAKE NGKLLNSIPN    50
    TRESRSGANA PEFSVSELSG AIKRALEEGF GYVRLRGEIS GYRGPHASGH 100
    CYFALKDDKA KIEAVVWKGT FGRLRFKPEE GMEVVAQGKI TTFPGSSKYQ 150
    IVIEALEPAG AGALMALLEE RKRKFAAEGL FDEDRKRPRP FLPKIVGIVT 200
    SPTGAVIRDM LHGFNERFPT RVLLWPVRVQ GEGSAAEVAA AIRGFNALEA 250
    DGTIPRPDVL IVARGGGSLE DLWSFNEEIV VRAVAESTIS LISAVGHETD 300
    WTLIDLVADA RAPTPTKAAE WAVPKYSELI ENVEKLMLRK RTAVRRAIES 350
    ARTHLKASAR GLPKLQDLVA LPRQRFDAAD RRLSRALLAN TRAHATRLAR 400
    VSGRLSPAPI VQKHSRCAER LDGLERRAGR ALLNRVAVSR RVLEGRAALL 450
    KSLGYQSVLS RGFALVRNEA GHMVRQAASL VAGDVLNIEF SDGRVGATVN 500
    GSDVSSATPD VSNPTSSKVK TPRQKSSGRG GQGSLF 536
    Length:536
    Mass (Da):57,739
    Last modified:September 21, 2011 - v1
    Checksum:i698D4A69845AA249
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ859181 Genomic DNA. Translation: CCB67039.1.
    RefSeqiWP_013949432.1. NC_015717.1.
    YP_004677605.1. NC_015717.1.

    Genome annotation databases

    EnsemblBacteriaiCCB67039; CCB67039; HYPMC_3829.
    GeneIDi10892318.
    KEGGihmc:HYPMC_3829.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ859181 Genomic DNA. Translation: CCB67039.1 .
    RefSeqi WP_013949432.1. NC_015717.1.
    YP_004677605.1. NC_015717.1.

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCB67039 ; CCB67039 ; HYPMC_3829 .
    GeneIDi 10892318.
    KEGGi hmc:HYPMC_3829.

    Phylogenomic databases

    KOi K03601.

    Enzyme and pathway databases

    BioCyci HSP717785:GJ7O-3837-MONOMER.

    Family and domain databases

    HAMAPi MF_00378. Exonuc_7_L.
    InterProi IPR003753. Exonuc_VII_L.
    IPR020579. Exonuc_VII_lsu_C.
    IPR025824. OB-fold_nuc-bd_dom.
    [Graphical view ]
    Pfami PF02601. Exonuc_VII_L. 1 hit.
    PF13742. tRNA_anti_2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00237. xseA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome of Hyphomicrobium sp. MC1."
      Genoscope.
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC1.

    Entry informationi

    Entry nameiF8JIN6_HYPSM
    AccessioniPrimary (citable) accession number: F8JIN6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: September 3, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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