F8JIN6 (F8JIN6_HYPSM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Exodeoxyribonuclease 7 large subunit HAMAP-Rule MF_00378
EC=3.1.11.6 HAMAP-Rule MF_00378

Alternative name(s):
Exodeoxyribonuclease VII large subunit HAMAP-Rule MF_00378

Gene names

Name:	xseA HAMAP-Rule MF_00378 EMBL CCB67039.1
Ordered Locus Names:	HYPMC_3829 EMBL CCB67039.1

Organism

Hyphomicrobium sp. (strain MC1) [Complete proteome] [HAMAP]

Taxonomic identifier

717785 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Hyphomicrobiaceae › Hyphomicrobium

Protein attributes

Sequence length	536 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides By similarity. SAAS SAAS025824 HAMAP-Rule MF_00378
Catalytic activity	Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. HAMAP-Rule MF_00378 Exonucleolytic cleavage in either 5'- to 3'-or 3'- to 5'-direction to yield nucleoside 5'-phosphates. SAAS SAAS025824
Subunit structure	Heterooligomer composed of large and small subunits By similarity. SAAS SAAS025824 HAMAP-Rule MF_00378
Subcellular location	Cytoplasm By similarity SAAS SAAS025824 HAMAP-Rule MF_00378.
Sequence similarities	Belongs to the XseA family. HAMAP-Rule MF_00378

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS025824 HAMAP-Rule MF_00378
Molecular function	Exonuclease SAAS SAAS025824 HAMAP-Rule MF_00378 EMBL CCB67039.1 Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA catabolic process Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell exodeoxyribonuclease VII complex Inferred from electronic annotation. Source: InterPro
Molecular_function	exodeoxyribonuclease VII activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F8JIN6 [UniParc]. Last modified September 21, 2011. Version 1. Checksum: 698D4A69845AA249	FASTA	536	57,739
	10 20 30 40 50 60 MLAAAGAEKK DIHQVACCNP VVSVASPCSI GGETSKTAKE NGKLLNSIPN TRESRSGANA 70 80 90 100 110 120 PEFSVSELSG AIKRALEEGF GYVRLRGEIS GYRGPHASGH CYFALKDDKA KIEAVVWKGT 130 140 150 160 170 180 FGRLRFKPEE GMEVVAQGKI TTFPGSSKYQ IVIEALEPAG AGALMALLEE RKRKFAAEGL 190 200 210 220 230 240 FDEDRKRPRP FLPKIVGIVT SPTGAVIRDM LHGFNERFPT RVLLWPVRVQ GEGSAAEVAA 250 260 270 280 290 300 AIRGFNALEA DGTIPRPDVL IVARGGGSLE DLWSFNEEIV VRAVAESTIS LISAVGHETD 310 320 330 340 350 360 WTLIDLVADA RAPTPTKAAE WAVPKYSELI ENVEKLMLRK RTAVRRAIES ARTHLKASAR 370 380 390 400 410 420 GLPKLQDLVA LPRQRFDAAD RRLSRALLAN TRAHATRLAR VSGRLSPAPI VQKHSRCAER 430 440 450 460 470 480 LDGLERRAGR ALLNRVAVSR RVLEGRAALL KSLGYQSVLS RGFALVRNEA GHMVRQAASL 490 500 510 520 530 VAGDVLNIEF SDGRVGATVN GSDVSSATPD VSNPTSSKVK TPRQKSSGRG GQGSLF

References

[1]	"The complete genome of Hyphomicrobium sp. MC1." Genoscope. Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FQ859181 Genomic DNA. Translation: CCB67039.1.
RefSeq	YP_004677605.1. NC_015717.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CCB67039; CCB67039; HYPMC_3829.
GeneID	10892318.
KEGG	hmc:HYPMC_3829.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K03601.
Enzyme and pathway databases
BioCyc	HSP717785:GJ7O-3837-MONOMER.
Family and domain databases
HAMAP	MF_00378. Exonuc_7_L.
InterPro	IPR003753. Exonuc_VII_L. IPR020579. Exonuc_VII_lsu_C. IPR025824. OB-fold_nuc-bd_dom. [Graphical view]
Pfam	PF02601. Exonuc_VII_L. 1 hit. PF13742. tRNA_anti_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00237. xseA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

F8JIN6_HYPSM

Accession

Primary (citable) accession number: F8JIN6

Entry history

Integrated into UniProtKB/TrEMBL:	September 21, 2011
Last sequence update:	September 21, 2011
Last modified:	April 3, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)