ID F8JHK1_HYPSM Unreviewed; 356 AA. AC F8JHK1; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 24-JAN-2024, entry version 53. DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727}; DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727}; GN OrderedLocusNames=HYPMC_2434 {ECO:0000313|EMBL:CCB65651.1}; OS Hyphomicrobium sp. (strain MC1). OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales; OC Hyphomicrobiaceae; Hyphomicrobium. OX NCBI_TaxID=717785 {ECO:0000313|EMBL:CCB65651.1, ECO:0000313|Proteomes:UP000000494}; RN [1] {ECO:0000313|Proteomes:UP000000494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MC1 {ECO:0000313|Proteomes:UP000000494}; RA Genoscope.; RT "The complete genome of Hyphomicrobium sp. MC1."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003}; CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family. CC {ECO:0000256|ARBA:ARBA00007572}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FQ859181; CCB65651.1; -; Genomic_DNA. DR AlphaFoldDB; F8JHK1; -. DR STRING; 717785.HYPMC_2434; -. DR KEGG; hmc:HYPMC_2434; -. DR eggNOG; COG1793; Bacteria. DR HOGENOM; CLU_008325_4_2_5; -. DR OMA; RWAYETK; -. DR Proteomes; UP000000494; Chromosome. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC. DR GO; GO:0006310; P:DNA recombination; IEA:InterPro. DR GO; GO:0006281; P:DNA repair; IEA:InterPro. DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1. DR CDD; cd07971; OBF_DNA_ligase_LigD; 1. DR Gene3D; 3.30.1490.70; -; 1. DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR InterPro; IPR012309; DNA_ligase_ATP-dep_C. DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent. DR InterPro; IPR014146; LigD_ligase_dom. DR InterPro; IPR012340; NA-bd_OB-fold. DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1. DR PANTHER; PTHR45674:SF4; DNA LIGASE 1; 1. DR PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1. DR Pfam; PF04679; DNA_ligase_A_C; 1. DR Pfam; PF01068; DNA_ligase_A_M; 1. DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR PROSITE; PS50160; DNA_LIGASE_A3; 1. PE 3: Inferred from homology; KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:CCB65651.1}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000494}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 235..258 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 135..270 FT /note="ATP-dependent DNA ligase family profile" FT /evidence="ECO:0000259|PROSITE:PS50160" SQ SEQUENCE 356 AA; 39471 MW; 4B6FD178BF76D939 CRC64; MRKAAPVKRP RSVPLKASAL KSGRGLVSPS KIEGAVKSAM PSFVEPCLAT LVAKPPIGEE WVHEIKFDGY RIQARIDRND VRLLTRNGLD WTDRFGGLAK ALAEFHRGKA IIDGELVVED ANGHSSFSAL AAALKSGRSE KFVLHCFDLL YLDGLNLIGA TLRDRKRLLE KLFVRRAKAG PIRYSGHLAV DGARMLSDAC SLGLEGIISK RIDRPYRSGR HDDWLKSKCI QVDEFVIVGY LVSSAGPNAV GALVVGYYDK KRLIYAGRVG TGYTHRTAAD LMRRLRPLHV DAPPVQGPLT NLQRRDVVWV RPDLVAQIEY RAWTGDGLLR HAAFKGLRED KPAKDVRRPI TKVIET //