ID F8IG53_ALIAT Unreviewed; 442 AA. AC F8IG53; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 27-MAR-2024, entry version 73. DE RecName: Full=Xylose isomerase {ECO:0000256|ARBA:ARBA00018232, ECO:0000256|HAMAP-Rule:MF_00455}; DE EC=5.3.1.5 {ECO:0000256|ARBA:ARBA00011958, ECO:0000256|HAMAP-Rule:MF_00455}; GN Name=xylA {ECO:0000256|HAMAP-Rule:MF_00455, GN ECO:0000313|EMBL:AEJ44206.1}; GN OrderedLocusNames=TC41_2305 {ECO:0000313|EMBL:AEJ44206.1}; OS Alicyclobacillus acidocaldarius (strain Tc-4-1) (Bacillus acidocaldarius). OC Bacteria; Bacillota; Bacilli; Bacillales; Alicyclobacillaceae; OC Alicyclobacillus. OX NCBI_TaxID=1048834 {ECO:0000313|EMBL:AEJ44206.1, ECO:0000313|Proteomes:UP000000292}; RN [1] {ECO:0000313|EMBL:AEJ44206.1, ECO:0000313|Proteomes:UP000000292} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tc-4-1 {ECO:0000313|EMBL:AEJ44206.1, RC ECO:0000313|Proteomes:UP000000292}; RX PubMed=21914900; DOI=10.1128/JB.05709-11; RA Chen Y., He Y., Zhang B., Yang J., Li W., Dong Z., Hu S.; RT "Complete Genome Sequence of Alicyclobacillus acidocaldarius Strain Tc- RT 4-1."; RL J. Bacteriol. 193:5602-5603(2011). RN [2] {ECO:0000313|Proteomes:UP000000292} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tc-4-1 {ECO:0000313|Proteomes:UP000000292}; RA Chen Y., He Y., Dong Z., Hu S.; RT "The complete genome sequence of Alicyclobacillus acidocaldarius sp. Tc-4- RT 1."; RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=alpha-D-xylose = alpha-D-xylulofuranose; Xref=Rhea:RHEA:22816, CC ChEBI:CHEBI:28518, ChEBI:CHEBI:188998; EC=5.3.1.5; CC Evidence={ECO:0000256|ARBA:ARBA00033659, ECO:0000256|HAMAP- CC Rule:MF_00455, ECO:0000256|RuleBase:RU000609}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP- CC Rule:MF_00455}; CC Note=Binds 2 magnesium ions per subunit. {ECO:0000256|HAMAP- CC Rule:MF_00455}; CC -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00455, CC ECO:0000256|RuleBase:RU000610}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, CC ECO:0000256|HAMAP-Rule:MF_00455, ECO:0000256|RuleBase:RU000610}. CC -!- SIMILARITY: Belongs to the xylose isomerase family. CC {ECO:0000256|ARBA:ARBA00005765, ECO:0000256|HAMAP-Rule:MF_00455, CC ECO:0000256|RuleBase:RU000609}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP002902; AEJ44206.1; -; Genomic_DNA. DR AlphaFoldDB; F8IG53; -. DR STRING; 1048834.TC41_2305; -. DR KEGG; aad:TC41_2305; -. DR PATRIC; fig|1048834.4.peg.2180; -. DR eggNOG; COG2115; Bacteria. DR HOGENOM; CLU_037261_1_0_9; -. DR Proteomes; UP000000292; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0009045; F:xylose isomerase activity; IEA:UniProtKB-UniRule. DR GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-UniRule. DR Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1. DR HAMAP; MF_00455; Xylose_isom_A; 1. DR InterPro; IPR036237; Xyl_isomerase-like_sf. DR InterPro; IPR013022; Xyl_isomerase-like_TIM-brl. DR InterPro; IPR013452; Xylose_isom_bac. DR InterPro; IPR001998; Xylose_isomerase. DR NCBIfam; TIGR02630; xylose_isom_A; 1. DR PANTHER; PTHR48320; -; 1. DR PANTHER; PTHR48320:SF1; XYLOSE ISOMERASE; 1. DR Pfam; PF01261; AP_endonuc_2; 1. DR PRINTS; PR00688; XYLOSISMRASE. DR SUPFAM; SSF51658; Xylose isomerase-like; 1. DR PROSITE; PS51415; XYLOSE_ISOMERASE; 1. PE 3: Inferred from homology; KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277, ECO:0000256|HAMAP- KW Rule:MF_00455}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00455}; KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|HAMAP-Rule:MF_00455}; KW Magnesium {ECO:0000256|HAMAP-Rule:MF_00455}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP- KW Rule:MF_00455}; KW Xylose metabolism {ECO:0000256|ARBA:ARBA00022629, ECO:0000256|HAMAP- KW Rule:MF_00455}. FT DOMAIN 94..285 FT /note="Xylose isomerase-like TIM barrel" FT /evidence="ECO:0000259|Pfam:PF01261" FT ACT_SITE 103 FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT ACT_SITE 106 FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 234 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="1" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 270 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="2" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 270 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="1" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 273 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="2" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 298 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="1" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 309 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="2" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 311 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="2" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 341 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="1" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" SQ SEQUENCE 442 AA; 50105 MW; 794673C7254F3F13 CRC64; MMDVATYFPE VTRIAYEGKG SDNPLCFKYY NPEETVLGKP MKEHLRFSVA YWHTFTLSGA DPFGLPNMIR PWDGATGMDL AKRRVEAAFE FMTKLGVEYF CFHDRDIAPE GDTLRETNRN LDEIVALIKE YMQSTGIKLL WNTQNLFSNP RFAHGAATAP DADVFAYAAA QVKKSLEIAK ELGAENYVFW GGREGYETLL NTDLKLELDN YARLLQMAVD YADEIGFTGQ FLIEPKPKEP TKHQYDFDVQ SGLAFLYHYG LKDRFKFNIE ANHATLAGHT FQHELRFARI NGLLGSVDAN QGDPLLGWDT DEFPTNLYET TLAMYEILLN GGLAPGGLNF DAKVRRASMT PIDLFYGHIA GMDSFARGLK VAAKLLEDRV FEREIEERYE SYRAGIGKDI VEGRATLQTL ESYVLDKRVT ATRSGRQEVL LAKLNQYLLE TE //