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F8IAW5

- F8IAW5_SULAT

UniProt

F8IAW5 - F8IAW5_SULAT

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Protein

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

Gene
murE, TPY_3479
Organism
Sulfobacillus acidophilus (strain TPY)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan By similarity.UniRule annotation

Catalytic activityi

ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diamino-heptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301UDP-MurNAc-L-Ala-D-Glu By similarityUniRule annotation
Binding sitei179 – 1791UDP-MurNAc-L-Ala-D-Glu By similarityUniRule annotation
Binding sitei187 – 1871UDP-MurNAc-L-Ala-D-Glu By similarityUniRule annotation
Binding sitei385 – 3851Meso-diaminopimelate By similarityUniRule annotation
Binding sitei461 – 4611Meso-diaminopimelate; via carbonyl oxygen By similarityUniRule annotation
Binding sitei465 – 4651Meso-diaminopimelate By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi110 – 1167ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotations

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotations, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciSACI1051632:GH78-3476-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligaseUniRule annotation (EC:6.3.2.13UniRule annotation)
Alternative name(s):
Meso-A2pm-adding enzyme
Meso-diaminopimelate-adding enzyme
UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase
UDP-MurNAc-tripeptide synthetase
UDP-N-acetylmuramyl-tripeptide synthetase
Gene namesi
Name:murEUniRule annotationImported
Ordered Locus Names:TPY_3479Imported
OrganismiSulfobacillus acidophilus (strain TPY)Imported
Taxonomic identifieri1051632 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVII. Incertae SedisSulfobacillus
ProteomesiUP000000291: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei219 – 2191N6-carboxylysine By similarityUniRule annotation

Post-translational modificationi

Carbamoylation is probably crucial for Mg2+ binding and, consequently, for the gamma-phosphate positioning of ATP By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni152 – 1532UDP-MurNAc-L-Ala-D-Glu binding By similarityUniRule annotation
Regioni409 – 4124Meso-diaminopimelate binding By similarityUniRule annotation

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi409 – 4124Meso-diaminopimelate recognition motif By similarityUniRule annotation

Sequence similaritiesi

Belongs to the MurCDEF family. MurE subfamily.UniRule annotation

Phylogenomic databases

KOiK01928.
OMAiLFICIEG.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00208. MurE.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005761. UDP-N-AcMur-Glu-dNH2Pim_ligase.
[Graphical view]
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR01085. murE. 1 hit.

Sequencei

Sequence statusi: Complete.

F8IAW5-1 [UniParc]FASTAAdd to Basket

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MTINEFANIL SHAQVVGDGS VTVGGIQYDS RRVEKGDLFC AIPGFHTDGH    50
LYCQEAYQRG AVAFLVERAD TVPKGAPALI VPEARPAMAI VADAFYGHPS 100
GRLWMVGVTG TNGKTTTTHL IRAVLEGSDI PCGLTGTLHT LIGQETFKVV 150
RTTPEAPDLQ RILRHMADRG MRAAVMEVSS HALVLSRVDA VEYDVGVFTN 200
LTQDHLDFHH DIESYFRAKA LLFERLGTGR PKGPRAAVIN RDDPYSERLM 250
GMTGVPVLTY GIQQPSDIRA TQVNITSRGV QFVAEFPEGV SQPVEFGMPG 300
RFNVLNALAA MAVGYVYGLT PSEMAESLAR YPGVPGRFER IDEGQPFTVI 350
VDYAHTPDGL ENALKTAREF SLGKIGVVFG AGGDRDRGKR PLMGEVAGRL 400
ADWTVLTADN PRSEDPLDII HQIAEGVNRV GGQWQQELDR ERAIRLALNQ 450
AQPGDVVLIV GKGHETYQIY RDATIHFDDR EVARQILREL NKG 493
Length:493
Mass (Da):53,949
Last modified:September 21, 2011 - v1
Checksum:iCC7A207DFC9AB60E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002901 Genomic DNA. Translation: AEJ41631.1.
RefSeqiWP_013988345.1. NC_015757.1.
YP_004721374.1. NC_015757.1.

Genome annotation databases

EnsemblBacteriaiAEJ41631; AEJ41631; TPY_3479.
GeneIDi10962146.
KEGGisay:TPY_3479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002901 Genomic DNA. Translation: AEJ41631.1 .
RefSeqi WP_013988345.1. NC_015757.1.
YP_004721374.1. NC_015757.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEJ41631 ; AEJ41631 ; TPY_3479 .
GeneIDi 10962146.
KEGGi say:TPY_3479.

Phylogenomic databases

KOi K01928.
OMAi LFICIEG.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci SACI1051632:GH78-3476-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPi MF_00208. MurE.
InterProi IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005761. UDP-N-AcMur-Glu-dNH2Pim_ligase.
[Graphical view ]
Pfami PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsi TIGR01085. murE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Analysis of Sulfobacillus acidophilus Strain TPY, Isolated from a Hydrothermal Vent in the Pacific Ocean."
    Li B., Chen Y., Liu Q., Hu S., Chen X.
    J. Bacteriol. 193:5555-5556(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TPYImported.

Entry informationi

Entry nameiF8IAW5_SULAT
AccessioniPrimary (citable) accession number: F8IAW5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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