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F8I5L9 (F8I5L9_SULAT) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AEJ38510.1
Ordered Locus Names:TPY_0308 EMBL AEJ38510.1
OrganismSulfobacillus acidophilus (strain TPY) [Complete proteome] [HAMAP] EMBL AEJ38510.1
Taxonomic identifier1051632 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVII. Incertae SedisSulfobacillus

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain132 – 339208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding165 – 22056ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2941Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3061Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3061Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3081Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F8I5L9 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 4D77F208A631EEF9

FASTA34937,130
        10         20         30         40         50         60 
MENIRVVVMM GGPSSEHDVS LASGSEVYHA LKSQPAFDVK ALTISRDGHW TLDSAPPEAL 

        70         80         90        100        110        120 
VPSGGSPTGT VSRQGAIRGV SLLAQADVVF LAFHGTFGED GTLQGLLETL GIPYTGSGPL 

       130        140        150        160        170        180 
ASALAMNKAK AKELFQYHGL ATPPGVVLSR REIQASLSSC AAYVKSRLTY PLVVKPNVGG 

       190        200        210        220        230        240 
SSLGAAMVDD AVDLEKALAD ASRYDLDVLV EERISGREFT CAVLEEMDGQ LRALPVIEII 

       250        260        270        280        290        300 
PKSGRFFDFT AKYQTGAADE ICPAPIPDAM RDTIQHMAIK AHDVLGCEGL SRADMIWTDQ 

       310        320        330        340 
GPVLLEVNTI PGMTRNSLVP KAARAAGIAF EGLVGHLVRL ALQRQQLRR 

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References

[1]"Complete Genome Analysis of Sulfobacillus acidophilus Strain TPY, Isolated from a Hydrothermal Vent in the Pacific Ocean."
Li B., Chen Y., Liu Q., Hu S., Chen X.
J. Bacteriol. 193:5555-5556(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TPY EMBL AEJ38510.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002901 Genomic DNA. Translation: AEJ38510.1.
RefSeqYP_004718253.1. NC_015757.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEJ38510; AEJ38510; TPY_0308.
GeneID10958980.
KEGGsay:TPY_0308.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAKYMDFSR.

Enzyme and pathway databases

BioCycSACI1051632:GH78-310-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8I5L9_SULAT
AccessionPrimary (citable) accession number: F8I5L9
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 19, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)