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F8I1A4

- F8I1A4_WEIKK

UniProt

F8I1A4 - F8I1A4_WEIKK

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Protein
Methionine--tRNA ligase
Gene
metG, WKK_03905
Organism
Weissella koreensis (strain KACC 15510)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Zinc By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. methionine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. methionyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationsImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding, RNA-binding, tRNA-bindingUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciWKOR1045854:GH3T-801-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine--tRNA ligaseUniRule annotation (EC:6.1.1.10UniRule annotation)
Alternative name(s):
Methionyl-tRNA synthetase
Gene namesi
Name:metGUniRule annotation
Ordered Locus Names:WKK_03905Imported
OrganismiWeissella koreensis (strain KACC 15510)Imported
Taxonomic identifieri1045854 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeWeissella
ProteomesiUP000008930: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF8I1A4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini571 – 674104tRNA-binding By similarityUniRule annotation
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi14 – 2411"HIGH" region By similarityUniRule annotation
Add
BLAST
Motifi309 – 3135"KMSKS" region By similarityUniRule annotation

Sequence similaritiesi

Contains 1 tRNA-binding domain.UniRule annotation
Contains tRNA-binding domain.SAAS annotations

Phylogenomic databases

KOiK01874.
OMAiQVCVVAN.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_01228. Met_tRNA_synth_type2.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR014758. Met-tRNA_synth.
IPR023457. Met-tRNA_synth_2.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR012340. NA-bd_OB-fold.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002547. tRNA-bd_dom.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF09334. tRNA-synt_1g. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view]
PRINTSiPR01041. TRNASYNTHMET.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50886. TRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8I1A4-1 [UniParc]FASTAAdd to Basket

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MTDKKTFYIT TPIYYPSGKL HIGNTYTTVL ADAAARYHRL LNEDVYYLTG    50
TDEHGLKIEQ KADKMGVTPQ AYVDSMADDI KKLWASLDIT NDGFIRTTDE 100
IHEKAVTKIF NQLLEQGDIY KGEYEGWYSV DDEEYFTESQ LAEAYRDESG 150
KVIGGKAPSG HEVELVKEES YFFAMSKYAD WLLEYYQAHP DFIQPVTRMN 200
EMINNFIKPG LEDLAVTRTS FKWGVPVESD PKHVIYVWID ALSNYITALG 250
YDSEDDSKFK KYWPANVQLL GKEIVRFHTI YWPIMLHALG LELPENVIGH 300
GWLTMKDGKM SKSKGNVVYP DVLADRYGVD AVRYYLLRAM PFGNDGIFTP 350
EDFVGKLNSD LANDLGNLLN RTVAMINKYE DGVIPTLETG ATEFDENLIE 400
ITDEVIAKYN ENMQILHVSD ALAEVWKLIS RANKYIDETQ PWVLAKNEEN 450
QSILASVMAH LAASLRVIAI LLQPALSRTP AEIFKQLGLS KSNLAIDQLK 500
FSDLPTGGKV ISKGTPIFPR IDVEKEVTYI RDSMMGGGKE TASVKKAKNA 550
ESKVQNVDQK EIKPNFIEFD DFEKVSLKVA EIKNVSEIEN SKKLLKFELD 600
DGTAKGRTIL SGIKKWYPEY QQLIGKKVAF VANLKPRTMM KKYVSEGMLL 650
SAEKDGNVTL SILPDEIEAG SELG 674
Length:674
Mass (Da):76,105
Last modified:September 21, 2011 - v1
Checksum:iA205B4441EA55BF4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002899 Genomic DNA. Translation: AEJ23655.1.
RefSeqiYP_004726334.1. NC_015759.1.

Genome annotation databases

EnsemblBacteriaiAEJ23655; AEJ23655; WKK_03905.
GeneIDi10954076.
KEGGiwko:WKK_03905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002899 Genomic DNA. Translation: AEJ23655.1 .
RefSeqi YP_004726334.1. NC_015759.1.

3D structure databases

ProteinModelPortali F8I1A4.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEJ23655 ; AEJ23655 ; WKK_03905 .
GeneIDi 10954076.
KEGGi wko:WKK_03905.

Phylogenomic databases

KOi K01874.
OMAi QVCVVAN.

Enzyme and pathway databases

BioCyci WKOR1045854:GH3T-801-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_01228. Met_tRNA_synth_type2.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR014758. Met-tRNA_synth.
IPR023457. Met-tRNA_synth_2.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR012340. NA-bd_OB-fold.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002547. tRNA-bd_dom.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
Pfami PF09334. tRNA-synt_1g. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view ]
PRINTSi PR01041. TRNASYNTHMET.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00398. metG. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50886. TRBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Weissella koreensis KACC 15510, isolated from Kimchi."
    Lee S.H., Jung J.Y., Lee S.H., Jeon C.O.
    J. Bacteriol. 193:5534-5534(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KACC 15510Imported.

Entry informationi

Entry nameiF8I1A4_WEIKK
AccessioniPrimary (citable) accession number: F8I1A4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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