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F8I1A4

- F8I1A4_WEIKK

UniProt

F8I1A4 - F8I1A4_WEIKK

Protein

Methionine--tRNA ligase

Gene

metG

Organism
Weissella koreensis (strain KACC 15510)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi161 – 1611ZincUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. methionine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. methionyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding, RNA-binding, tRNA-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciWKOR1045854:GH3T-801-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionine--tRNA ligaseUniRule annotation (EC:6.1.1.10UniRule annotation)
    Alternative name(s):
    Methionyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:metGUniRule annotation
    Ordered Locus Names:WKK_03905Imported
    OrganismiWeissella koreensis (strain KACC 15510)Imported
    Taxonomic identifieri1045854 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeWeissella
    ProteomesiUP000008930: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF8I1A4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini571 – 674104tRNA-bindingUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi14 – 2411"HIGH" regionUniRule annotationAdd
    BLAST
    Motifi309 – 3135"KMSKS" regionUniRule annotation

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.UniRule annotation
    Contains 1 tRNA-binding domain.UniRule annotation
    Contains tRNA-binding domain.SAAS annotation

    Phylogenomic databases

    KOiK01874.
    OMAiQVCVVAN.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    2.40.50.140. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_01228. Met_tRNA_synth_type2.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR014758. Met-tRNA_synth.
    IPR023457. Met-tRNA_synth_2.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR012340. NA-bd_OB-fold.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002547. tRNA-bd_dom.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PfamiPF09334. tRNA-synt_1g. 1 hit.
    PF01588. tRNA_bind. 1 hit.
    [Graphical view]
    PRINTSiPR01041. TRNASYNTHMET.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00398. metG. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    PS50886. TRBD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8I1A4-1 [UniParc]FASTAAdd to Basket

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    MTDKKTFYIT TPIYYPSGKL HIGNTYTTVL ADAAARYHRL LNEDVYYLTG    50
    TDEHGLKIEQ KADKMGVTPQ AYVDSMADDI KKLWASLDIT NDGFIRTTDE 100
    IHEKAVTKIF NQLLEQGDIY KGEYEGWYSV DDEEYFTESQ LAEAYRDESG 150
    KVIGGKAPSG HEVELVKEES YFFAMSKYAD WLLEYYQAHP DFIQPVTRMN 200
    EMINNFIKPG LEDLAVTRTS FKWGVPVESD PKHVIYVWID ALSNYITALG 250
    YDSEDDSKFK KYWPANVQLL GKEIVRFHTI YWPIMLHALG LELPENVIGH 300
    GWLTMKDGKM SKSKGNVVYP DVLADRYGVD AVRYYLLRAM PFGNDGIFTP 350
    EDFVGKLNSD LANDLGNLLN RTVAMINKYE DGVIPTLETG ATEFDENLIE 400
    ITDEVIAKYN ENMQILHVSD ALAEVWKLIS RANKYIDETQ PWVLAKNEEN 450
    QSILASVMAH LAASLRVIAI LLQPALSRTP AEIFKQLGLS KSNLAIDQLK 500
    FSDLPTGGKV ISKGTPIFPR IDVEKEVTYI RDSMMGGGKE TASVKKAKNA 550
    ESKVQNVDQK EIKPNFIEFD DFEKVSLKVA EIKNVSEIEN SKKLLKFELD 600
    DGTAKGRTIL SGIKKWYPEY QQLIGKKVAF VANLKPRTMM KKYVSEGMLL 650
    SAEKDGNVTL SILPDEIEAG SELG 674
    Length:674
    Mass (Da):76,105
    Last modified:September 21, 2011 - v1
    Checksum:iA205B4441EA55BF4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002899 Genomic DNA. Translation: AEJ23655.1.
    RefSeqiYP_004726334.1. NC_015759.1.

    Genome annotation databases

    EnsemblBacteriaiAEJ23655; AEJ23655; WKK_03905.
    GeneIDi10954076.
    KEGGiwko:WKK_03905.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002899 Genomic DNA. Translation: AEJ23655.1 .
    RefSeqi YP_004726334.1. NC_015759.1.

    3D structure databases

    ProteinModelPortali F8I1A4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEJ23655 ; AEJ23655 ; WKK_03905 .
    GeneIDi 10954076.
    KEGGi wko:WKK_03905.

    Phylogenomic databases

    KOi K01874.
    OMAi QVCVVAN.

    Enzyme and pathway databases

    BioCyci WKOR1045854:GH3T-801-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    2.40.50.140. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_01228. Met_tRNA_synth_type2.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR014758. Met-tRNA_synth.
    IPR023457. Met-tRNA_synth_2.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR012340. NA-bd_OB-fold.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002547. tRNA-bd_dom.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    Pfami PF09334. tRNA-synt_1g. 1 hit.
    PF01588. tRNA_bind. 1 hit.
    [Graphical view ]
    PRINTSi PR01041. TRNASYNTHMET.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00398. metG. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    PS50886. TRBD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Weissella koreensis KACC 15510, isolated from Kimchi."
      Lee S.H., Jung J.Y., Lee S.H., Jeon C.O.
      J. Bacteriol. 193:5534-5534(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KACC 15510Imported.

    Entry informationi

    Entry nameiF8I1A4_WEIKK
    AccessioniPrimary (citable) accession number: F8I1A4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3