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F8HZ69 (F8HZ69_WEIKK) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AEJ23778.1
Ordered Locus Names:WKK_04530 EMBL AEJ23778.1
OrganismWeissella koreensis (strain KACC 15510) [Complete proteome] [HAMAP] EMBL AEJ23778.1
Taxonomic identifier1045854 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeWeissella

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain140 – 347208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding170 – 22657ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3011Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3141Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3141Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3161Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F8HZ69 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: EB9F68B6360CC572

FASTA38242,609
        10         20         30         40         50         60 
MSEKLNVAML FGGNSSEHDV SKRSAHNIYD AMDKEKYNVT IFLISKAGYV MNPEVSWRVF 

        70         80         90        100        110        120 
EGEDEDPIVA EAMKDLDTTS PLAPIINLGK VDQIDLFYPV VHGNLGEDGT LQALFRLLQK 

       130        140        150        160        170        180 
PYIGAGTAAS AMSFDKDLTK RILDHAGVRN TKYVLLTDLN SQEYSYEKLV AELGTDVLFV 

       190        200        210        220        230        240 
KAAKQGSSVG IARVTNEAEY QQGLKEAFQY DYKVLVEAGL KRPREVFISV LGNEHPRVSK 

       250        260        270        280        290        300 
IGGIVLPEND EWYDYNNKFV DASGMVFELP AELPEATVKE IETMALKAYR ALGLVGLTRM 

       310        320        330        340        350        360 
DFMLDEDGTP YLGEPNTLPG FTNISLYPQM WQVSGISYSE LIDEIINYGL AEFKRNAALS 

       370        380 
YDFVSLGEEH VGEKKYNADV KE 

« Hide

References

[1]"Complete Genome Sequence of Weissella koreensis KACC 15510, Isolated from Kimchi."
Lee S.H., Jung J.Y., Lee S.H., Jeon C.O.
J. Bacteriol. 193:5534-5534(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KACC 15510 EMBL AEJ23778.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002899 Genomic DNA. Translation: AEJ23778.1.
RefSeqYP_004726457.1. NC_015759.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEJ23778; AEJ23778; WKK_04530.
GeneID10954217.
KEGGwko:WKK_04530.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAKLAFQYD.

Enzyme and pathway databases

BioCycWKOR1045854:GH3T-942-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8HZ69_WEIKK
AccessionPrimary (citable) accession number: F8HZ69
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: July 9, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)