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Protein

Xylose isomerase

Gene

xylA

Organism
Weissella koreensis (strain KACC 15510)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei112 – 1121UniRule annotation
Active sitei115 – 1151UniRule annotation
Metal bindingi243 – 2431Magnesium 1UniRule annotation
Metal bindingi279 – 2791Magnesium 1UniRule annotation
Metal bindingi279 – 2791Magnesium 2UniRule annotation
Metal bindingi282 – 2821Magnesium 2UniRule annotation
Metal bindingi307 – 3071Magnesium 1UniRule annotation
Metal bindingi318 – 3181Magnesium 2UniRule annotation
Metal bindingi320 – 3201Magnesium 2UniRule annotation
Metal bindingi350 – 3501Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciWKOR1045854:GH3T-933-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:WKK_04485Imported
OrganismiWeissella koreensis (strain KACC 15510)Imported
Taxonomic identifieri1045854 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeWeissella
ProteomesiUP000008930: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliF8HZ60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

KOiK01805.
OMAiHTFQHEL.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8HZ60-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAELFDFPKV EFIGGKKGLD FEQSKGYNFY NADEEFTING ETKAMKDWLK
60 70 80 90 100
FSVAYWHTMD QRLVDPFGEG TAVRPWDENG QDDMSDMEHA KSKVKYMFEF
110 120 130 140 150
MDKLGVEYFA FHDRDLAPEG KTLAETNANL DIIVDMIEAE MKRTGKKLLW
160 170 180 190 200
NTSSLFTNKR FVSGGATAPF ADVFAYAGAQ IKHSLEIAKR LNSESYVFWG
210 220 230 240 250
GREGYDSLLN TDTKRELDHI ADFYKLAIDY AKEIGYTGQF LLEPKPKEPT
260 270 280 290 300
THQYDTDVQT TISFLYTYGL QDNFKLNLEG NHAFLAGHTY EHEARFAREA
310 320 330 340 350
GLLGSLDANM GDKQTGWDID EFPNDIYEAT LVMYEFIKNG GLPTGGLNFD
360 370 380 390 400
AKARRSSFTM EDLFYGHMAG MDVYAAGFRV AYKLVQDNFF ENILKNRYAS
410 420 430 440 450
FDSGIGADFE AGKVTFADME KYILNKEDSE ILDTVKSGRI EAIKASLNNY
460
IYSVLGETFK K
Length:461
Mass (Da):52,444
Last modified:September 21, 2011 - v1
Checksum:i3630CF72A8F39BB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002899 Genomic DNA. Translation: AEJ23769.1.
RefSeqiYP_004726448.1. NC_015759.1.

Genome annotation databases

EnsemblBacteriaiAEJ23769; AEJ23769; WKK_04485.
GeneIDi10954208.
KEGGiwko:WKK_04485.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002899 Genomic DNA. Translation: AEJ23769.1.
RefSeqiYP_004726448.1. NC_015759.1.

3D structure databases

ProteinModelPortaliF8HZ60.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEJ23769; AEJ23769; WKK_04485.
GeneIDi10954208.
KEGGiwko:WKK_04485.

Phylogenomic databases

KOiK01805.
OMAiHTFQHEL.

Enzyme and pathway databases

BioCyciWKOR1045854:GH3T-933-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Weissella koreensis KACC 15510, isolated from Kimchi."
    Lee S.H., Jung J.Y., Lee S.H., Jeon C.O.
    J. Bacteriol. 193:5534-5534(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KACC 15510Imported.

Entry informationi

Entry nameiF8HZ60_WEIKK
AccessioniPrimary (citable) accession number: F8HZ60
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 4, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.