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F8HGB4 (F8HGB4_STRE5) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AEJ52853.1
Ordered Locus Names:Ssal_00472 EMBL AEJ52853.1
OrganismStreptococcus salivarius (strain 57.I) [Complete proteome] [HAMAP] EMBL AEJ52853.1
Taxonomic identifier1046629 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain132 – 334203ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding162 – 21756ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2881Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3011Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3011Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3031Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F8HGB4 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 43690460F6392945

FASTA34838,284
        10         20         30         40         50         60 
MSKQTLILLY GGRSAEREVS VLSAESVMRA VDYSAFEVKT YFITQSGDFI KTQEFTETPG 

        70         80         90        100        110        120 
DDEKLMTNAT VVASQAIKPS DIYEEGAVVF PVLHGPMGED GSIQGFLETL KLPYVGTNVL 

       130        140        150        160        170        180 
SSSVAMDKIM TKHILEVAGV PQVAYTVFIE GEDLEVAVAE TLEKLTFPVF VKPANMGSSV 

       190        200        210        220        230        240 
GISKAENEAE LRAAIDLALK YDSRILIEQG VVAREIEVGI LGNTNVKTTD PGEVVKDVAF 

       250        260        270        280        290        300 
YDYQAKYIDN KITMDIPAHV PAEVMTQMRA YAAKAFRALG GCGLARCDFF LTEDGAIYLN 

       310        320        330        340 
ELNTMPGFTQ WSMYPLLWEN MGLSYSDLIK ELVALGQEMF DKRESHLI 

« Hide

References

[1]"Complete Genome Sequence of the Ureolytic Streptococcus salivarius Strain 57.I."
Geng J., Huang S.C., Li S., Hu S., Chen Y.Y.
J. Bacteriol. 193:5596-5597(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 57.I EMBL AEJ52853.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002888 Genomic DNA. Translation: AEJ52853.1.
RefSeqYP_006067716.1. NC_017594.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEJ52853; AEJ52853; Ssal_00472.
GeneID12895446.
KEGGstf:Ssal_00472.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAQIDVIFP.

Enzyme and pathway databases

BioCycSSAL1046629:GLLG-437-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8HGB4_STRE5
AccessionPrimary (citable) accession number: F8HGB4
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: July 9, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)