ID   F8GWA8_CUPNN            Unreviewed;       560 AA.
AC   F8GWA8;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Acetyl-coenzyme A synthetase AcsA {ECO:0000313|EMBL:AEI81683.1};
DE            EC=6.2.1.1 {ECO:0000313|EMBL:AEI81683.1};
GN   Name=acsA1 {ECO:0000313|EMBL:AEI81683.1};
GN   OrderedLocusNames=CNE_BB1p02590 {ECO:0000313|EMBL:AEI81683.1};
OS   Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453
OS   / N-1) (Ralstonia eutropha).
OG   Plasmid pBB1 {ECO:0000313|EMBL:AEI81683.1,
OG   ECO:0000313|Proteomes:UP000006798}.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=1042878 {ECO:0000313|EMBL:AEI81683.1, ECO:0000313|Proteomes:UP000006798};
RN   [1] {ECO:0000313|EMBL:AEI81683.1, ECO:0000313|Proteomes:UP000006798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1
RC   {ECO:0000313|Proteomes:UP000006798};
RC   PLASMID=pBB1 {ECO:0000313|EMBL:AEI81683.1,
RC   ECO:0000313|Proteomes:UP000006798};
RX   PubMed=21742890; DOI=10.1128/JB.05660-11;
RA   Poehlein A., Kusian B., Friedrich B., Daniel R., Bowien B.;
RT   "Complete genome sequence of the type strain Cupriavidus necator N-1.";
RL   J. Bacteriol. 193:5017-5017(2011).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; CP002879; AEI81683.1; -; Genomic_DNA.
DR   AlphaFoldDB; F8GWA8; -.
DR   KEGG; cnc:CNE_BB1p02590; -.
DR   HOGENOM; CLU_000022_59_10_4; -.
DR   Proteomes; UP000006798; Plasmid pBB1.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR   PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AEI81683.1};
KW   Plasmid {ECO:0000313|EMBL:AEI81683.1}.
FT   DOMAIN          51..394
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          459..537
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   560 AA;  60445 MW;  6BD21686CC296463 CRC64;
     MEILSPLAEL GERVSELIDH YADSSASLAW MLCDRHDPAS VAYDIVDANL RVERLTYGEL
     RVQSEAFAAG LLDLGVRSGD RVATLAGKSL EYLVALLGIW RIGAVHVPLF TAFAPPAVAL
     RLEGSGARVV VCDASQRSKL SSSEDGEPAP RYDIVVISDD ELSLEEPALH RYQDVLKAGH
     RVSPAALGGD APFIHIYTSG TTGKPKGVVV PSRAIAAFHA YVEFGIGLRA DDVYWCAADP
     GWAYGLYFGV VGSLCTGVQS VFQKGGFDPA LTYDVLRQCG VTNFAAAPTV FRSLMCADVT
     APAGLHLRSA SSAGEPLTPD VNEWAAQALG VSVYDHYGQT EAGMLINNHH DPRLVRPIQS
     GCMGISMPGW KAVVLDRTED VEVPPGTVGR IAFKLADSPL AWFAGYDGLP EKSAEKFSRD
     GQYYLSGDLA RADETGAFFF SSREDDVIIM AGYRIGPFEV ESVLTAHPAV AECAVIAVPD
     KVRGEVIEAY VVLRPGFEAT DEAAVELQQW VKTRYAAHAY PRRVTFISEL PKTPSGKVQR
     FVLREARKNA DLDGKGDEKH
//