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F8GL95

- F8GL95_NITSI

UniProt

F8GL95 - F8GL95_NITSI

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Protein

Ribulose bisphosphate carboxylase large chain

Gene
cbbL, Nit79A3_3235
Organism
Nitrosomonas sp. (strain Is79A3)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301Substrate; in homodimeric partner By similarityUniRule annotation
Binding sitei180 – 1801Substrate By similarityUniRule annotation
Active sitei182 – 1821Proton acceptor By similarityUniRule annotation
Binding sitei184 – 1841Substrate By similarityUniRule annotation
Metal bindingi208 – 2081Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi210 – 2101Magnesium By similarityUniRule annotation
Metal bindingi211 – 2111Magnesium By similarityUniRule annotation
Active sitei300 – 3001Proton acceptor By similarityUniRule annotation
Binding sitei301 – 3011Substrate By similarityUniRule annotation
Binding sitei333 – 3331Substrate By similarityUniRule annotation
Sitei340 – 3401Transition state stabilizer By similarityUniRule annotation
Binding sitei385 – 3851Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. monooxygenase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. reductive pentose-phosphate cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation, MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Biological processi

Calvin cycleUniRule annotation, Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciNSP261292:GH7H-3270-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCO large subunitUniRule annotation
Gene namesi
Name:cbbLUniRule annotation
Ordered Locus Names:Nit79A3_3235Imported
OrganismiNitrosomonas sp. (strain Is79A3)Imported
Taxonomic identifieri261292 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000000501: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei208 – 2081N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Heterohexadecamer of 8 large chains and 8 small chains By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01601.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01338. RuBisCO_L_type1.
InterProiIPR020878. RuBisCo_large_chain_AS.
IPR020888. RuBisCO_lsu.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8GL95-1 [UniParc]FASTAAdd to Basket

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MASETMKEGK ERYKSGVIPY KKMGYWEPSY VPKDTDVIAL FRITPQPGVD    50
HEEAAAAVAG ESSTATWTVV WTDRLTACEL YRAKAYKSEL VPNTGPGTKN 100
EAQYFAYIAY DIDLFEEGSI ANLTASIIGN VFGFKAVKAL RLEDMRIPVA 150
YLKTFQGPAT GIVVERERLD KFGRPLLGAT TKPKLGLSGR NYGRVVYEGL 200
KGGLDFMKDD ENINSQPFMH WRDRFLYCME AVNKASAATG EVKGHYLNVT 250
AGTMEDMYER AEFAKSLGSV IVMIDLVIGY TAIQSMAKWA RRNDMILHLH 300
RAGNSTYSRQ KNHGMNFRVI CKWMRMAGVD HIHAGTVVGK LEGDPLMIKG 350
FYDTLRDTHT EKNLEHGLFF DQDWASLNKV MPVASGGIHA GQMHQLLDYL 400
GEDVILQFGG GTIGHPQGIQ AGATANRVAL EAMVLARNEG RDYVKEGPQI 450
LADAAKWCTP LKQALDTWKD ITFNYDSTDT ADFVPSATAN V 491
Length:491
Mass (Da):54,472
Last modified:September 21, 2011 - v1
Checksum:iE1561A3351780AF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002876 Genomic DNA. Translation: AEJ02969.1.
RefSeqiWP_013967179.1. NC_015731.1.
YP_004696368.1. NC_015731.1.

Genome annotation databases

EnsemblBacteriaiAEJ02969; AEJ02969; Nit79A3_3235.
GeneIDi10935341.
KEGGinii:Nit79A3_3235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002876 Genomic DNA. Translation: AEJ02969.1 .
RefSeqi WP_013967179.1. NC_015731.1.
YP_004696368.1. NC_015731.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEJ02969 ; AEJ02969 ; Nit79A3_3235 .
GeneIDi 10935341.
KEGGi nii:Nit79A3_3235.

Phylogenomic databases

KOi K01601.

Enzyme and pathway databases

BioCyci NSP261292:GH7H-3270-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01338. RuBisCO_L_type1.
InterProi IPR020878. RuBisCo_large_chain_AS.
IPR020888. RuBisCO_lsu.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Is79A3Imported.

Entry informationi

Entry nameiF8GL95_NITSI
AccessioniPrimary (citable) accession number: F8GL95
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel" By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi