F8GBJ7 (F8GBJ7_FRAST) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase [NADP]; Monomeric isocitrate dehydrogenase [NADP] EMBL AEI35764.1
EC=1.1.1.42 EMBL AEI35764.1

Gene names

Ordered Locus Names:

F7308_0837

Organism

Francisella sp. (strain TX077308) [Complete proteome] [HAMAP] EMBL AEI35764.1

Taxonomic identifier

573569 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella

Protein attributes

Sequence length	738 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Molecular function	Oxidoreductase EMBL AEI35764.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	130 – 137	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	348	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	546	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	550	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	143	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	545	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	253	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	418	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	F8GBJ7 [UniParc]. Last modified September 21, 2011. Version 1. Checksum: 7A47B71419334175	FASTA	738	82,068
	10 20 30 40 50 60 MHKIFYTFTD EAPALATGSF LPIVESFTKV ADIELETKDI SLAARILANF NDCLTDEQKC 70 80 90 100 110 120 SDNLAILGEL AKTPDANIIK LPNISASIPQ LTAAIKELQS KGYKIPDYPF EPKDDEEQEI 130 140 150 160 170 180 KARYAKVLGS AVNPVLREGN SDRRVADAVK KYAEKHPHSM GAWTKDSKSH VASMADNDFY 190 200 210 220 230 240 ANEKSYIVPK ATKVKIVHTD TKGTQTVLKD NLALEEKEII DATKISIKAL REFYKTEIAK 250 260 270 280 290 300 AKKEGTLLSL HLKATMMKVS DPILFGHAVE IFFEDVFKKY AKEFKELGVN PRNGWGDAVE 310 320 330 340 350 360 KIKQLPQDLQ DKINTDIEKV FAKQPDIAMV NSDKGITNLN VPSDVIIDAS MPAAIRSSGQ 370 380 390 400 410 420 MWNKDGKLQD MKAMIPDRCY AGVYAATIDF CKENGAFDVA TMGDVSNVGL MAKKAEEYGS 430 440 450 460 470 480 HDKTFEIQAD GKVEVIDIEG NVILEHQVEK GDIWRACQTK DIAVKDWVKL AINRARITQN 490 500 510 520 530 540 PAIFWLDSKR AHDRNLIAKV NEYKVLHDTT GLDIQILAPI EATKYSLKRM KEGKNTISVT 550 560 570 580 590 600 GNVLRDYLTD LFPILELGTS AKMLSIVPLL AGGGLFETGA GGSAPKHVEQ LIEENHLRWD 610 620 630 640 650 660 SLGEFLALGA SLEDLAIKTR DPKIKVLAEA LSQANQDFLD NDKSPKRKVG ELDTRGSHFY 670 680 690 700 710 720 LAYYWVKALA EQTGNAEIKA RFEPIYAELK TNEDKIVKEL NDAQGKKVDV GGYYFMDSDK 730 LAKVMRPSKT LNSILAKL

References

[1]	"The complete genome of Francisella sp. TX077308." Kuske C.R., Challacombe J.F., Siddaramappa S., Petersen J.M. Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TX077308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002872 Genomic DNA. Translation: AEI35764.1.
RefSeq	YP_004647364.1. NC_015696.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEI35764; AEI35764; F7308_0837.
GeneID	10861842.
KEGG	frt:F7308_0837.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00031.
Enzyme and pathway databases
BioCyc	FSP573569:GHZ6-856-MONOMER.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

F8GBJ7_FRAST

Accession

Primary (citable) accession number: F8GBJ7

Entry history

Integrated into UniProtKB/TrEMBL:	September 21, 2011
Last sequence update:	September 21, 2011
Last modified:	April 3, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)