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Protein
Submitted name:

Isocitrate dehydrogenase [NADP] Monomeric isocitrate dehydrogenase [NADP]

Gene

F7308_0837

Organism
Francisella sp. (strain TX077308)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431SubstrateUniRule annotation
Sitei253 – 2531Critical for catalysisUniRule annotation
Metal bindingi348 – 3481Magnesium or manganeseUniRule annotation
Sitei418 – 4181Critical for catalysisUniRule annotation
Binding sitei545 – 5451SubstrateUniRule annotation
Metal bindingi546 – 5461Magnesium or manganeseUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciFSP573569:GHZ6-857-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase [NADP] Monomeric isocitrate dehydrogenase [NADP]Imported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:F7308_0837Imported
OrganismiFrancisella sp. (strain TX077308)Imported
Taxonomic identifieri573569 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000000490 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi573569.F7308_0837.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

F8GBJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKIFYTFTD EAPALATGSF LPIVESFTKV ADIELETKDI SLAARILANF
60 70 80 90 100
NDCLTDEQKC SDNLAILGEL AKTPDANIIK LPNISASIPQ LTAAIKELQS
110 120 130 140 150
KGYKIPDYPF EPKDDEEQEI KARYAKVLGS AVNPVLREGN SDRRVADAVK
160 170 180 190 200
KYAEKHPHSM GAWTKDSKSH VASMADNDFY ANEKSYIVPK ATKVKIVHTD
210 220 230 240 250
TKGTQTVLKD NLALEEKEII DATKISIKAL REFYKTEIAK AKKEGTLLSL
260 270 280 290 300
HLKATMMKVS DPILFGHAVE IFFEDVFKKY AKEFKELGVN PRNGWGDAVE
310 320 330 340 350
KIKQLPQDLQ DKINTDIEKV FAKQPDIAMV NSDKGITNLN VPSDVIIDAS
360 370 380 390 400
MPAAIRSSGQ MWNKDGKLQD MKAMIPDRCY AGVYAATIDF CKENGAFDVA
410 420 430 440 450
TMGDVSNVGL MAKKAEEYGS HDKTFEIQAD GKVEVIDIEG NVILEHQVEK
460 470 480 490 500
GDIWRACQTK DIAVKDWVKL AINRARITQN PAIFWLDSKR AHDRNLIAKV
510 520 530 540 550
NEYKVLHDTT GLDIQILAPI EATKYSLKRM KEGKNTISVT GNVLRDYLTD
560 570 580 590 600
LFPILELGTS AKMLSIVPLL AGGGLFETGA GGSAPKHVEQ LIEENHLRWD
610 620 630 640 650
SLGEFLALGA SLEDLAIKTR DPKIKVLAEA LSQANQDFLD NDKSPKRKVG
660 670 680 690 700
ELDTRGSHFY LAYYWVKALA EQTGNAEIKA RFEPIYAELK TNEDKIVKEL
710 720 730
NDAQGKKVDV GGYYFMDSDK LAKVMRPSKT LNSILAKL
Length:738
Mass (Da):82,068
Last modified:September 21, 2011 - v1
Checksum:i7A47B71419334175
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002872 Genomic DNA. Translation: AEI35764.1.
RefSeqiWP_013922603.1. NC_015696.1.
YP_004647364.1. NC_015696.1.

Genome annotation databases

EnsemblBacteriaiAEI35764; AEI35764; F7308_0837.
KEGGifrt:F7308_0837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002872 Genomic DNA. Translation: AEI35764.1.
RefSeqiWP_013922603.1. NC_015696.1.
YP_004647364.1. NC_015696.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi573569.F7308_0837.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEI35764; AEI35764; F7308_0837.
KEGGifrt:F7308_0837.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciFSP573569:GHZ6-857-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome of Francisella sp. TX077308."
    Kuske C.R., Challacombe J.F., Siddaramappa S., Petersen J.M.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TX077308Imported.

Entry informationi

Entry nameiF8GBJ7_FRAST
AccessioniPrimary (citable) accession number: F8GBJ7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 24, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.