Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

F8GBJ7

- F8GBJ7_FRAST

UniProt

F8GBJ7 - F8GBJ7_FRAST

Protein
Submitted name:

Isocitrate dehydrogenase [NADP] Monomeric isocitrate dehydrogenase [NADP]

Gene

F7308_0837

Organism
Francisella sp. (strain TX077308)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei143 – 1431Substrate
    Sitei253 – 2531Critical for catalysisUniRule annotation
    Metal bindingi348 – 3481Magnesium or manganeseUniRule annotation
    Sitei418 – 4181Critical for catalysisUniRule annotation
    Binding sitei545 – 5451SubstrateUniRule annotation
    Metal bindingi546 – 5461Magnesium or manganeseUniRule annotation
    Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciFSP573569:GHZ6-857-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase [NADP] Monomeric isocitrate dehydrogenase [NADP]Imported (EC:1.1.1.42Imported)
    Gene namesi
    Ordered Locus Names:F7308_0837Imported
    OrganismiFrancisella sp. (strain TX077308)Imported
    Taxonomic identifieri573569 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000000490: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1378Substrate binding

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F8GBJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHKIFYTFTD EAPALATGSF LPIVESFTKV ADIELETKDI SLAARILANF    50
    NDCLTDEQKC SDNLAILGEL AKTPDANIIK LPNISASIPQ LTAAIKELQS 100
    KGYKIPDYPF EPKDDEEQEI KARYAKVLGS AVNPVLREGN SDRRVADAVK 150
    KYAEKHPHSM GAWTKDSKSH VASMADNDFY ANEKSYIVPK ATKVKIVHTD 200
    TKGTQTVLKD NLALEEKEII DATKISIKAL REFYKTEIAK AKKEGTLLSL 250
    HLKATMMKVS DPILFGHAVE IFFEDVFKKY AKEFKELGVN PRNGWGDAVE 300
    KIKQLPQDLQ DKINTDIEKV FAKQPDIAMV NSDKGITNLN VPSDVIIDAS 350
    MPAAIRSSGQ MWNKDGKLQD MKAMIPDRCY AGVYAATIDF CKENGAFDVA 400
    TMGDVSNVGL MAKKAEEYGS HDKTFEIQAD GKVEVIDIEG NVILEHQVEK 450
    GDIWRACQTK DIAVKDWVKL AINRARITQN PAIFWLDSKR AHDRNLIAKV 500
    NEYKVLHDTT GLDIQILAPI EATKYSLKRM KEGKNTISVT GNVLRDYLTD 550
    LFPILELGTS AKMLSIVPLL AGGGLFETGA GGSAPKHVEQ LIEENHLRWD 600
    SLGEFLALGA SLEDLAIKTR DPKIKVLAEA LSQANQDFLD NDKSPKRKVG 650
    ELDTRGSHFY LAYYWVKALA EQTGNAEIKA RFEPIYAELK TNEDKIVKEL 700
    NDAQGKKVDV GGYYFMDSDK LAKVMRPSKT LNSILAKL 738
    Length:738
    Mass (Da):82,068
    Last modified:September 21, 2011 - v1
    Checksum:i7A47B71419334175
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002872 Genomic DNA. Translation: AEI35764.1.
    RefSeqiWP_013922603.1. NC_015696.1.
    YP_004647364.1. NC_015696.1.

    Genome annotation databases

    EnsemblBacteriaiAEI35764; AEI35764; F7308_0837.
    GeneIDi10861842.
    KEGGifrt:F7308_0837.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002872 Genomic DNA. Translation: AEI35764.1 .
    RefSeqi WP_013922603.1. NC_015696.1.
    YP_004647364.1. NC_015696.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEI35764 ; AEI35764 ; F7308_0837 .
    GeneIDi 10861842.
    KEGGi frt:F7308_0837.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci FSP573569:GHZ6-857-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome of Francisella sp. TX077308."
      Kuske C.R., Challacombe J.F., Siddaramappa S., Petersen J.M.
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TX077308Imported.

    Entry informationi

    Entry nameiF8GBJ7_FRAST
    AccessioniPrimary (citable) accession number: F8GBJ7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3