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F8GBJ7

- F8GBJ7_FRAST

UniProt

F8GBJ7 - F8GBJ7_FRAST

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Protein
Submitted name:

Isocitrate dehydrogenase [NADP] Monomeric isocitrate dehydrogenase [NADP]

Gene
F7308_0837
Organism
Francisella sp. (strain TX077308)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431Substrate By similarityUniRule annotation
Sitei253 – 2531Critical for catalysis By similarityUniRule annotation
Metal bindingi348 – 3481Magnesium or manganese By similarityUniRule annotation
Sitei418 – 4181Critical for catalysis By similarityUniRule annotation
Binding sitei545 – 5451Substrate By similarityUniRule annotation
Metal bindingi546 – 5461Magnesium or manganese By similarityUniRule annotation
Metal bindingi550 – 5501Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciFSP573569:GHZ6-857-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase [NADP] Monomeric isocitrate dehydrogenase [NADP]Imported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:F7308_0837Imported
OrganismiFrancisella sp. (strain TX077308)Imported
Taxonomic identifieri573569 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000000490: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate binding By similarityUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

F8GBJ7-1 [UniParc]FASTAAdd to Basket

« Hide

MHKIFYTFTD EAPALATGSF LPIVESFTKV ADIELETKDI SLAARILANF    50
NDCLTDEQKC SDNLAILGEL AKTPDANIIK LPNISASIPQ LTAAIKELQS 100
KGYKIPDYPF EPKDDEEQEI KARYAKVLGS AVNPVLREGN SDRRVADAVK 150
KYAEKHPHSM GAWTKDSKSH VASMADNDFY ANEKSYIVPK ATKVKIVHTD 200
TKGTQTVLKD NLALEEKEII DATKISIKAL REFYKTEIAK AKKEGTLLSL 250
HLKATMMKVS DPILFGHAVE IFFEDVFKKY AKEFKELGVN PRNGWGDAVE 300
KIKQLPQDLQ DKINTDIEKV FAKQPDIAMV NSDKGITNLN VPSDVIIDAS 350
MPAAIRSSGQ MWNKDGKLQD MKAMIPDRCY AGVYAATIDF CKENGAFDVA 400
TMGDVSNVGL MAKKAEEYGS HDKTFEIQAD GKVEVIDIEG NVILEHQVEK 450
GDIWRACQTK DIAVKDWVKL AINRARITQN PAIFWLDSKR AHDRNLIAKV 500
NEYKVLHDTT GLDIQILAPI EATKYSLKRM KEGKNTISVT GNVLRDYLTD 550
LFPILELGTS AKMLSIVPLL AGGGLFETGA GGSAPKHVEQ LIEENHLRWD 600
SLGEFLALGA SLEDLAIKTR DPKIKVLAEA LSQANQDFLD NDKSPKRKVG 650
ELDTRGSHFY LAYYWVKALA EQTGNAEIKA RFEPIYAELK TNEDKIVKEL 700
NDAQGKKVDV GGYYFMDSDK LAKVMRPSKT LNSILAKL 738
Length:738
Mass (Da):82,068
Last modified:September 21, 2011 - v1
Checksum:i7A47B71419334175
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002872 Genomic DNA. Translation: AEI35764.1.
RefSeqiWP_013922603.1. NC_015696.1.
YP_004647364.1. NC_015696.1.

Genome annotation databases

EnsemblBacteriaiAEI35764; AEI35764; F7308_0837.
GeneIDi10861842.
KEGGifrt:F7308_0837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002872 Genomic DNA. Translation: AEI35764.1 .
RefSeqi WP_013922603.1. NC_015696.1.
YP_004647364.1. NC_015696.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI35764 ; AEI35764 ; F7308_0837 .
GeneIDi 10861842.
KEGGi frt:F7308_0837.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci FSP573569:GHZ6-857-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome of Francisella sp. TX077308."
    Kuske C.R., Challacombe J.F., Siddaramappa S., Petersen J.M.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TX077308.

Entry informationi

Entry nameiF8GBJ7_FRAST
AccessioniPrimary (citable) accession number: F8GBJ7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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