F8GAW9 (F8GAW9_FRAST) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable aspartoacylase HAMAP-Rule MF_00704
EC=3.5.1.15 HAMAP-Rule MF_00704

Gene names

Ordered Locus Names:

F7308_1921

Organism

Francisella sp. (strain TX077308) [Complete proteome] [HAMAP] EMBL AEI36845.1

Taxonomic identifier

573569 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acyl-L-aspartate + H2O = a carboxylate + L-aspartate. HAMAP-Rule MF_00704
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00704
Sequence similarities	Belongs to the AspA/AstE family. Aspartoacylase subfamily. HAMAP-Rule MF_00704

Ontologies

Keywords
Ligand	Metal-binding HAMAP-Rule MF_00704 Zinc HAMAP-Rule MF_00704
Molecular function	Hydrolase HAMAP-Rule MF_00704
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	aspartoacylase activity Inferred from electronic annotation. Source: HAMAP hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	60 – 61	2	Substrate binding By similarity HAMAP-Rule MF_00704
Sites
	Metal binding	13	1	Zinc By similarity HAMAP-Rule MF_00704
	Metal binding	16	1	Zinc By similarity HAMAP-Rule MF_00704
	Metal binding	103	1	Zinc By similarity HAMAP-Rule MF_00704
	Binding site	53	1	Substrate By similarity HAMAP-Rule MF_00704
	Binding site	160	1	Substrate By similarity HAMAP-Rule MF_00704
	Binding site	270	1	Substrate By similarity HAMAP-Rule MF_00704

Sequences

	Sequence		Length	Mass (Da)
	F8GAW9 [UniParc]. Last modified September 21, 2011. Version 1. Checksum: C058E9A49FE24B69	FASTA	289	32,587
	10 20 30 40 50 60 MKINKLLVSG GTHGNEYTGI YIVKRMEKYP PKTKSLDVIP LLANPEAFEI SKRYKDQDLN 70 80 90 100 110 120 RCFSEEDLKK ISLNSYEMQR AREINQMYGS ESNSPVDFLV DLHTTTSNLG KTIITDGKSQ 130 140 150 160 170 180 FVNNLCSYLV EQIDDLRVIK HGSITSVAMN NIAPMSLTIE IGSVNTSIYD PNAIEVTTEI 190 200 210 220 230 240 VNGIIKFIEL SNNGNAPEVK QCKAYEPFKT IQYPRDSEGN INVVIHKALH GKDFQIISSG 250 260 270 280 SPIFELIDGG DRLLDIEGEW YPIFINESAY YEKDIAFYLA KEVDLYSDS

References

[1]	"The complete genome of Francisella sp. TX077308." Kuske C.R., Challacombe J.F., Siddaramappa S., Petersen J.M. Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TX077308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002872 Genomic DNA. Translation: AEI36845.1.
RefSeq	YP_004648445.1. NC_015696.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEI36845; AEI36845; F7308_1921.
GeneID	10862947.
KEGG	frt:F7308_1921.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K01437.
Enzyme and pathway databases
BioCyc	FSP573569:GHZ6-1961-MONOMER.
Family and domain databases
HAMAP	MF_00704. Aspartoacylase.
InterPro	IPR016708. Aspartoacylase. IPR007036. Aste_AspA. [Graphical view]
Pfam	PF04952. AstE_AspA. 1 hit. [Graphical view]
PIRSF	PIRSF018001. Aspartoacylase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

F8GAW9_FRAST

Accession

Primary (citable) accession number: F8GAW9

Entry history

Integrated into UniProtKB/TrEMBL:	September 21, 2011
Last sequence update:	September 21, 2011
Last modified:	April 3, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)