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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Francisella sp. (strain TX077308)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

BioCyciFSP573569:G1GYT-664-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotationSAAS annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:F7308_0660Imported
OrganismiFrancisella sp. (strain TX077308)Imported
Taxonomic identifieri573569 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000000490 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi573569.F7308_0660

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 148Nudix hydrolaseInterPro annotationAdd BLAST143

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 59Nudix boxUniRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105EJF Bacteria
COG0494 LUCA
KOiK08311
OrthoDBiPOG091H0392

Family and domain databases

CDDicd03671 Ap4A_hydrolase_plant_like, 1 hit
HAMAPiMF_00298 Nudix_RppH, 1 hit
InterProiView protein in InterPro
IPR020476 Nudix_hydrolase
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
IPR022927 RppH
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PRINTSiPR00502 NUDIXFAMILY
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

Sequencei

Sequence statusi: Complete.

F8GAQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDKSGYRAN VAIVLLNRQN RVFWGQRKSR TSWQFPQGGV AVGETPLQAM
60 70 80 90 100
YRELYEEIGL RPHDVEVIAS TRDWFKYDIP DSLVRSREPV CIGQKQKWFL
110 120 130 140 150
LRLKTSENNI NLEANDSPEF DNWRWVSYWY PINHVVYFKQ EVYRKALTYF

KEYIN
Length:155
Mass (Da):18,617
Last modified:September 21, 2011 - v1
Checksum:i13BBBA36DE55CC18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002872 Genomic DNA Translation: AEI35587.1
RefSeqiWP_013922429.1, NC_015696.1

Genome annotation databases

EnsemblBacteriaiAEI35587; AEI35587; F7308_0660
KEGGifrt:F7308_0660

Similar proteinsi

Entry informationi

Entry nameiF8GAQ2_FRAST
AccessioniPrimary (citable) accession number: F8GAQ2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 28, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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