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F8GAQ2

- F8GAQ2_FRAST

UniProt

F8GAQ2 - F8GAQ2_FRAST

Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Francisella sp. (strain TX077308)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotationSAAS annotation

    Cofactori

    Divalent ions.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciFSP573569:GHZ6-676-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
    Alternative name(s):
    (Di)nucleoside polyphosphate hydrolaseUniRule annotation
    Gene namesi
    Name:rppHUniRule annotation
    Synonyms:nudHUniRule annotation
    Ordered Locus Names:F7308_0660Imported
    OrganismiFrancisella sp. (strain TX077308)Imported
    Taxonomic identifieri573569 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000000490: Chromosome

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 148143Nudix hydrolaseUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi38 – 5922Nudix boxUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation
    Contains 1 nudix hydrolase domain.UniRule annotation
    Contains nudix hydrolase domain.SAAS annotation

    Phylogenomic databases

    KOiK08311.

    Family and domain databases

    Gene3Di3.90.79.10. 1 hit.
    HAMAPiMF_00298. Nudix_RppH.
    InterProiIPR020476. Nudix_hydrolase.
    IPR020084. NUDIX_hydrolase_CS.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    IPR022927. RppH.
    [Graphical view]
    PfamiPF00293. NUDIX. 1 hit.
    [Graphical view]
    PRINTSiPR00502. NUDIXFAMILY.
    SUPFAMiSSF55811. SSF55811. 1 hit.
    PROSITEiPS51462. NUDIX. 1 hit.
    PS00893. NUDIX_BOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8GAQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIDKSGYRAN VAIVLLNRQN RVFWGQRKSR TSWQFPQGGV AVGETPLQAM    50
    YRELYEEIGL RPHDVEVIAS TRDWFKYDIP DSLVRSREPV CIGQKQKWFL 100
    LRLKTSENNI NLEANDSPEF DNWRWVSYWY PINHVVYFKQ EVYRKALTYF 150
    KEYIN 155
    Length:155
    Mass (Da):18,617
    Last modified:September 21, 2011 - v1
    Checksum:i13BBBA36DE55CC18
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002872 Genomic DNA. Translation: AEI35587.1.
    RefSeqiWP_013922429.1. NC_015696.1.
    YP_004647187.1. NC_015696.1.

    Genome annotation databases

    EnsemblBacteriaiAEI35587; AEI35587; F7308_0660.
    GeneIDi10861661.
    KEGGifrt:F7308_0660.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002872 Genomic DNA. Translation: AEI35587.1 .
    RefSeqi WP_013922429.1. NC_015696.1.
    YP_004647187.1. NC_015696.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEI35587 ; AEI35587 ; F7308_0660 .
    GeneIDi 10861661.
    KEGGi frt:F7308_0660.

    Phylogenomic databases

    KOi K08311.

    Enzyme and pathway databases

    BioCyci FSP573569:GHZ6-676-MONOMER.

    Family and domain databases

    Gene3Di 3.90.79.10. 1 hit.
    HAMAPi MF_00298. Nudix_RppH.
    InterProi IPR020476. Nudix_hydrolase.
    IPR020084. NUDIX_hydrolase_CS.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    IPR022927. RppH.
    [Graphical view ]
    Pfami PF00293. NUDIX. 1 hit.
    [Graphical view ]
    PRINTSi PR00502. NUDIXFAMILY.
    SUPFAMi SSF55811. SSF55811. 1 hit.
    PROSITEi PS51462. NUDIX. 1 hit.
    PS00893. NUDIX_BOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome of Francisella sp. TX077308."
      Kuske C.R., Challacombe J.F., Siddaramappa S., Petersen J.M.
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TX077308Imported.

    Entry informationi

    Entry nameiF8GAQ2_FRAST
    AccessioniPrimary (citable) accession number: F8GAQ2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3