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F8G7W6 (F8G7W6_FRAST) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:F7308_0154 EMBL AEI35082.1
OrganismFrancisella sp. (strain TX077308) [Complete proteome] [HAMAP] EMBL AEI35082.1
Taxonomic identifier573569 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain103 – 293191ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding129 – 18052ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2471Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2601Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2601Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2621Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F8G7W6 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: AB1957CEE65EC243

FASTA29732,975
        10         20         30         40         50         60 
MQKEKIVVLY GGDSPEREVS LKSGKAVLDS LLNQGYDASG LDASSKDLVT KLIELNPDKC 

        70         80         90        100        110        120 
FIALHGEDGE NGRVAALLEM LGIKHTGSTM KSCVITMDKM ISKEIWMHHR MPTPMAKFLT 

       130        140        150        160        170        180 
DKLVESDEIS FPVAVKPSNG GSSIATFKVK NFKELEEAYK QASEHGEVMI EQWVTGKEIT 

       190        200        210        220        230        240 
VAIVNNDVYS SVWIEPLNEF YDYESKYSGK SIYHAPSGLC EQKELEVRQL AKKAYDLLGC 

       250        260        270        280        290 
KGHARVDFIY DDRGDFYIME INSSPGMTEN SLSPKSAAAE GIDFDSFVKS ILEQAQC 

« Hide

References

[1]"The complete genome of Francisella sp. TX077308."
Kuske C.R., Challacombe J.F., Siddaramappa S., Petersen J.M.
Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TX077308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002872 Genomic DNA. Translation: AEI35082.1.
RefSeqYP_004646682.1. NC_015696.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEI35082; AEI35082; F7308_0154.
GeneID10861141.
KEGGfrt:F7308_0154.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycFSP573569:GHZ6-155-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8G7W6_FRAST
AccessionPrimary (citable) accession number: F8G7W6
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 11, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)