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F8G5R9

- F8G5R9_PSEP6

UniProt

F8G5R9 - F8G5R9_PSEP6

Protein

Isocitrate dehydrogenase [NADP]

Gene

PPS_3421

Organism
Pseudomonas putida (strain S16)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciPPUT1042876:GH0R-3379-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:PPS_3421Imported
    OrganismiPseudomonas putida (strain S16)Imported
    Taxonomic identifieri1042876 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000502: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8G5R9-1 [UniParc]FASTAAdd to Basket

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    MGYQKIKVPT DGTKITVNAD HSLNVPDNPI IPYIEGDGIG VDVSPVMIKV    50
    VDAAVQKAYG GKRKIAWMEV YAGEKATQVY DQDTWLPQET LDAVRDYVVS 100
    IKGPLTTPVG GGIRSLNVAL RQQLDLYVCL RPVLWFQGVP SPVKKPGDVD 150
    MVIFRENSED IYAGIEWKAG SPEANKVIKF LKEEMGVTKI RFDQDCGIGV 200
    KPVSREGTKR LVRKALQYVV DNDRESLTLV HKGNIMKFTE GAFKDWGYEV 250
    ARDEFGAELL DGGPWMKFKN PKSGREVIVK DAIADAMLQQ ILLRPAEYDV 300
    IATLNLNGDY LSDALAAEVG GIGIAPGANL SDTVAMFEAT HGTAPKYAGQ 350
    DKVNPGSVIL SAEMMLRHMG WTEAADLIIK GTNGAIAAKT VTYDFERLMD 400
    GATLVSSSGF GDEMIKHM 418
    Length:418
    Mass (Da):45,645
    Last modified:September 21, 2011 - v1
    Checksum:iA0F3056014634DBC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002870 Genomic DNA. Translation: AEJ13968.1.
    RefSeqiYP_004702848.1. NC_015733.1.

    Genome annotation databases

    EnsemblBacteriaiAEJ13968; AEJ13968; PPS_3421.
    GeneIDi10939051.
    KEGGippt:PPS_3421.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002870 Genomic DNA. Translation: AEJ13968.1 .
    RefSeqi YP_004702848.1. NC_015733.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEJ13968 ; AEJ13968 ; PPS_3421 .
    GeneIDi 10939051.
    KEGGi ppt:PPS_3421.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci PPUT1042876:GH0R-3379-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the nicotine-degrading Pseudomonas putida strain S16."
      Yu H., Tang H., Wang L., Yao Y., Wu G., Xu P.
      J. Bacteriol. 193:5541-5542(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S16Imported.

    Entry informationi

    Entry nameiF8G5R9_PSEP6
    AccessioniPrimary (citable) accession number: F8G5R9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3