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Protein

Isocitrate dehydrogenase [NADP]

Gene

PPS_3421

Organism
Pseudomonas putida (strain S16)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciPPUT1042876:GH0R-3379-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:PPS_3421Imported
OrganismiPseudomonas putida (strain S16)Imported
Taxonomic identifieri1042876 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000502: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8G5R9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGYQKIKVPT DGTKITVNAD HSLNVPDNPI IPYIEGDGIG VDVSPVMIKV
60 70 80 90 100
VDAAVQKAYG GKRKIAWMEV YAGEKATQVY DQDTWLPQET LDAVRDYVVS
110 120 130 140 150
IKGPLTTPVG GGIRSLNVAL RQQLDLYVCL RPVLWFQGVP SPVKKPGDVD
160 170 180 190 200
MVIFRENSED IYAGIEWKAG SPEANKVIKF LKEEMGVTKI RFDQDCGIGV
210 220 230 240 250
KPVSREGTKR LVRKALQYVV DNDRESLTLV HKGNIMKFTE GAFKDWGYEV
260 270 280 290 300
ARDEFGAELL DGGPWMKFKN PKSGREVIVK DAIADAMLQQ ILLRPAEYDV
310 320 330 340 350
IATLNLNGDY LSDALAAEVG GIGIAPGANL SDTVAMFEAT HGTAPKYAGQ
360 370 380 390 400
DKVNPGSVIL SAEMMLRHMG WTEAADLIIK GTNGAIAAKT VTYDFERLMD
410
GATLVSSSGF GDEMIKHM
Length:418
Mass (Da):45,645
Last modified:September 21, 2011 - v1
Checksum:iA0F3056014634DBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002870 Genomic DNA. Translation: AEJ13968.1.
RefSeqiYP_004702848.1. NC_015733.1.

Genome annotation databases

EnsemblBacteriaiAEJ13968; AEJ13968; PPS_3421.
GeneIDi10939051.
KEGGippt:PPS_3421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002870 Genomic DNA. Translation: AEJ13968.1.
RefSeqiYP_004702848.1. NC_015733.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEJ13968; AEJ13968; PPS_3421.
GeneIDi10939051.
KEGGippt:PPS_3421.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciPPUT1042876:GH0R-3379-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the nicotine-degrading Pseudomonas putida strain S16."
    Yu H., Tang H., Wang L., Yao Y., Wu G., Xu P.
    J. Bacteriol. 193:5541-5542(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S16Imported.

Entry informationi

Entry nameiF8G5R9_PSEP6
AccessioniPrimary (citable) accession number: F8G5R9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 4, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.