F8FPU0 (F8FPU0_PAEMK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 2 HAMAP-Rule MF_00713
EC=1.4.4.2 HAMAP-Rule MF_00713

Alternative name(s):
Glycine cleavage system P-protein subunit 2 HAMAP-Rule MF_00713
Glycine decarboxylase subunit 2 HAMAP-Rule MF_00713

Gene names

Name:	gcvPB HAMAP-Rule MF_00713 EMBL AEI45907.1
Ordered Locus Names:	KNP414_07403 EMBL AEI45907.1

Organism

Paenibacillus mucilaginosus (strain KNP414) [Complete proteome] [HAMAP]

Taxonomic identifier

1036673 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Paenibacillaceae › Paenibacillus › Paenibacillus mucilaginosus

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00713 SAAS SAAS020581
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP-Rule MF_00713 SAAS SAAS020581
Cofactor	Pyridoxal phosphate By similarity. HAMAP-Rule MF_00713 SAAS SAAS020581
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity. HAMAP-Rule MF_00713 SAAS SAAS020581
Sequence similarities	Belongs to the GcvP family. C-terminal subunit subfamily. HAMAP-Rule MF_00713

Ontologies

Keywords
Ligand	Pyridoxal phosphate HAMAP-Rule MF_00713 SAAS SAAS020581
Molecular function	Oxidoreductase HAMAP-Rule MF_00713 SAAS SAAS020581
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Molecular_function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	277	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_00713

Sequences

	Sequence		Length	Mass (Da)
	F8FPU0 [UniParc]. Last modified September 21, 2011. Version 1. Checksum: 7B846599A18317AF	FASTA	491	54,086
	10 20 30 40 50 60 MTEAFRVKDD QPLIFELSRP GRTAYSLPPC DVPETDPREL IPAELLREKP PALPEVYEVD 70 80 90 100 110 120 VVRHYTALSR RNFGVDNGFY PLGSCTMKYN PKLHEDAARL DGFAKIHPYQ PEESIQGALE 130 140 150 160 170 180 LLYRLQEDLA GLTGMDEVTL QPAAGAHGEW TGLMMIRAYH EARGEKRSKV LVPDSSHGTN 190 200 210 220 230 240 PASATAAGFE TVTLPSGPDG LVDLERLREA AGPDTAALML TNPNTLGLFE SRITEIAAIV 250 260 270 280 290 300 HEAGGLLYYD GANSNAIMGI TRPGDMGFDV VHLNLHKTMS TPHGGGGPGA GPVGVKKLLA 310 320 330 340 350 360 PFLPKPVVAR RADGSYTLDG ERPDSIGRVK AFYGNFGILL RAYAYIRSYG PEGLRRVSEC 370 380 390 400 410 420 AVLNANYMLR RLAGHYDVPY DRICKHEFVL SGRGLKKHGI RTLDVAKRLL DFGYHPPTIY 430 440 450 460 470 480 FPLNVEECIM IEPTETESKE TLDGFIDTMI RIAEEAERDP DLLKNAPYTT PVRRLDETQA 490 ARKPVLNCSC E

References

[1]	"Complete genome sequence of Paenibacillus mucilaginosus KNP414." Wang J., Hu S., Hu X., Zhang B., Dong D., Zhang S., Zhao K., Wu D. Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KNP414 EMBL AEI45907.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002869 Genomic DNA. Translation: AEI45907.1.
RefSeq	YP_004645777.1. NC_015690.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEI45907; AEI45907; KNP414_07403.
GeneID	10860282.
KEGG	pms:KNP414_07403.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00283.
Enzyme and pathway databases
BioCyc	PMUC1036673:GJD1-7403-MONOMER.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
HAMAP	MF_00713. GcvPB.
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR023012. GDC_P_su2. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11773. PTHR11773. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

F8FPU0_PAEMK

Accession

Primary (citable) accession number: F8FPU0

Entry history

Integrated into UniProtKB/TrEMBL:	September 21, 2011
Last sequence update:	September 21, 2011
Last modified:	April 3, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)