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F8FPR2

- F8FPR2_PAEMK

UniProt

F8FPR2 - F8FPR2_PAEMK

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Protein

Thymidine kinase

Gene
tdk, KNP414_07372
Organism
Paenibacillus mucilaginosus (strain KNP414)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741Proton acceptor By similarityUniRule annotation
Metal bindingi131 – 1311Zinc By similarityUniRule annotation
Metal bindingi134 – 1341Zinc By similarityUniRule annotation
Metal bindingi168 – 1681Zinc By similarityUniRule annotation
Metal bindingi171 – 1711Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 764ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotations, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciPMUC1036673:GJD1-7372-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:KNP414_07372Imported
OrganismiPaenibacillus mucilaginosus (strain KNP414)Imported
Taxonomic identifieri1036673 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000006620: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00857.
OMAiELKTVCH.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8FPR2-1 [UniParc]FASTAAdd to Basket

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MNSGKSIEVL RVAHNYEEQG KKVLLFTPAV DDREGVGVVA SRIGMRKDGI    50
IIDEHLDMVA MAAQERPNCI LIDEAQFLTK AQVEQLTEIT DTLGIPVITY 100
GLRGDFLGQL FEGSMHLFAL ADKIEEIKTV CWYCDRKATM NMRCKDGVPV 150
FTGEQIQIGG NESYIPVCRK CYSRQKKTAA AQ 182
Length:182
Mass (Da):20,303
Last modified:September 21, 2011 - v1
Checksum:iC6A0BFD34F05552B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002869 Genomic DNA. Translation: AEI45879.1.
RefSeqiYP_004645749.1. NC_015690.1.

Genome annotation databases

EnsemblBacteriaiAEI45879; AEI45879; KNP414_07372.
GeneIDi10860251.
KEGGipms:KNP414_07372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002869 Genomic DNA. Translation: AEI45879.1 .
RefSeqi YP_004645749.1. NC_015690.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI45879 ; AEI45879 ; KNP414_07372 .
GeneIDi 10860251.
KEGGi pms:KNP414_07372.

Phylogenomic databases

KOi K00857.
OMAi ELKTVCH.

Enzyme and pathway databases

BioCyci PMUC1036673:GJD1-7372-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Paenibacillus mucilaginosus KNP414."
    Wang J., Hu S., Hu X., Zhang B., Dong D., Zhang S., Zhao K., Wu D.
    Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KNP414.

Entry informationi

Entry nameiF8FPR2_PAEMK
AccessioniPrimary (citable) accession number: F8FPR2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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