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F8FPR2

- F8FPR2_PAEMK

UniProt

F8FPR2 - F8FPR2_PAEMK

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Protein

Thymidine kinase

Gene

tdk

Organism
Paenibacillus mucilaginosus (strain KNP414)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741Proton acceptorUniRule annotation
Metal bindingi131 – 1311ZincUniRule annotation
Metal bindingi134 – 1341ZincUniRule annotation
Metal bindingi168 – 1681ZincUniRule annotation
Metal bindingi171 – 1711ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 764ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPMUC1036673:GJD1-7372-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:KNP414_07372Imported
OrganismiPaenibacillus mucilaginosus (strain KNP414)Imported
Taxonomic identifieri1036673 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000006620: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.
OMAiELKTVCH.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8FPR2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSGKSIEVL RVAHNYEEQG KKVLLFTPAV DDREGVGVVA SRIGMRKDGI
60 70 80 90 100
IIDEHLDMVA MAAQERPNCI LIDEAQFLTK AQVEQLTEIT DTLGIPVITY
110 120 130 140 150
GLRGDFLGQL FEGSMHLFAL ADKIEEIKTV CWYCDRKATM NMRCKDGVPV
160 170 180
FTGEQIQIGG NESYIPVCRK CYSRQKKTAA AQ
Length:182
Mass (Da):20,303
Last modified:September 21, 2011 - v1
Checksum:iC6A0BFD34F05552B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002869 Genomic DNA. Translation: AEI45879.1.
RefSeqiYP_004645749.1. NC_015690.1.

Genome annotation databases

EnsemblBacteriaiAEI45879; AEI45879; KNP414_07372.
GeneIDi10860251.
KEGGipms:KNP414_07372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002869 Genomic DNA. Translation: AEI45879.1 .
RefSeqi YP_004645749.1. NC_015690.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI45879 ; AEI45879 ; KNP414_07372 .
GeneIDi 10860251.
KEGGi pms:KNP414_07372.

Phylogenomic databases

KOi K00857.
OMAi ELKTVCH.

Enzyme and pathway databases

BioCyci PMUC1036673:GJD1-7372-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Paenibacillus mucilaginosus KNP414."
    Wang J., Hu S., Hu X., Zhang B., Dong D., Zhang S., Zhao K., Wu D.
    Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KNP414Imported.

Entry informationi

Entry nameiF8FPR2_PAEMK
AccessioniPrimary (citable) accession number: F8FPR2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3