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F8FPR2

- F8FPR2_PAEMK

UniProt

F8FPR2 - F8FPR2_PAEMK

Protein

Thymidine kinase

Gene

tdk

Organism
Paenibacillus mucilaginosus (strain KNP414)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei74 – 741Proton acceptorUniRule annotation
    Metal bindingi131 – 1311ZincUniRule annotation
    Metal bindingi134 – 1341ZincUniRule annotation
    Metal bindingi168 – 1681ZincUniRule annotation
    Metal bindingi171 – 1711ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi73 – 764ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciPMUC1036673:GJD1-7372-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:KNP414_07372Imported
    OrganismiPaenibacillus mucilaginosus (strain KNP414)Imported
    Taxonomic identifieri1036673 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
    ProteomesiUP000006620: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.
    OMAiELKTVCH.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8FPR2-1 [UniParc]FASTAAdd to Basket

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    MNSGKSIEVL RVAHNYEEQG KKVLLFTPAV DDREGVGVVA SRIGMRKDGI    50
    IIDEHLDMVA MAAQERPNCI LIDEAQFLTK AQVEQLTEIT DTLGIPVITY 100
    GLRGDFLGQL FEGSMHLFAL ADKIEEIKTV CWYCDRKATM NMRCKDGVPV 150
    FTGEQIQIGG NESYIPVCRK CYSRQKKTAA AQ 182
    Length:182
    Mass (Da):20,303
    Last modified:September 21, 2011 - v1
    Checksum:iC6A0BFD34F05552B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002869 Genomic DNA. Translation: AEI45879.1.
    RefSeqiYP_004645749.1. NC_015690.1.

    Genome annotation databases

    EnsemblBacteriaiAEI45879; AEI45879; KNP414_07372.
    GeneIDi10860251.
    KEGGipms:KNP414_07372.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002869 Genomic DNA. Translation: AEI45879.1 .
    RefSeqi YP_004645749.1. NC_015690.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEI45879 ; AEI45879 ; KNP414_07372 .
    GeneIDi 10860251.
    KEGGi pms:KNP414_07372.

    Phylogenomic databases

    KOi K00857.
    OMAi ELKTVCH.

    Enzyme and pathway databases

    BioCyci PMUC1036673:GJD1-7372-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Paenibacillus mucilaginosus KNP414."
      Wang J., Hu S., Hu X., Zhang B., Dong D., Zhang S., Zhao K., Wu D.
      Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KNP414Imported.

    Entry informationi

    Entry nameiF8FPR2_PAEMK
    AccessioniPrimary (citable) accession number: F8FPR2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3