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F8EWC4

- F8EWC4_ZYMMT

UniProt

F8EWC4 - F8EWC4_ZYMMT

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Protein

N5-carboxyaminoimidazole ribonucleotide synthase

Gene

Zymop_1645

Organism
Zymomonas mobilis subsp. pomaceae (strain ATCC 29192 / JCM 10191 / NBRC 13757 / NCIMB 11200 / NRRL B-4491)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).UniRule annotation

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 5-(carboxyamino)imidazole ribonucleotide synthase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: InterPro
  4. phosphoribosylaminoimidazole carboxylase activity Source: InterPro

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation, LyaseImported

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciZMOB579138:GJDN-1708-MONOMER.
UniPathwayiUPA00074; UER00942.

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide synthaseUniRule annotation (EC:6.3.4.18UniRule annotation)
Short name:
N5-CAIR synthaseUniRule annotation
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide synthetaseUniRule annotation
Gene namesi
Ordered Locus Names:Zymop_1645Imported
OrganismiZymomonas mobilis subsp. pomaceae (strain ATCC 29192 / JCM 10191 / NBRC 13757 / NCIMB 11200 / NRRL B-4491)Imported
Taxonomic identifieri579138 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000000491: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PurK/PurT family.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

KOiK01589.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01161. purK. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8EWC4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKTFPPGSK IGIIGNGQLG QMMAIAAIQL GYFCHIYAPN QHGPANIVAA
60 70 80 90 100
KSFVGDYGDS DKLNEFAATV DVLTYEFENI PAEPLIDLSK QMPVYPPPRA
110 120 130 140 150
LQIAQDRLVE KNYAAEQGIR PAPFRAVNSA KELSYALLEL GVPAILKQRT
160 170 180 190 200
QGYDGRGQFP VKKMTDAHLA EIWNSLSVKQ AVLEGMVRFE YEFSVIAVRN
210 220 230 240 250
ADGQFLTWDV PVNTHNKGIL AHSVVPANEF IQQQADAAIK ATHKIADSLG
260 270 280 290 300
YVGVLAVEFF ATQFGPIFNE MAPRVHNSGH WTIEGSETSQ FENHIRAICG
310 320 330 340 350
LPLGSTALTA EKVEMKNLIG TQINTWEKIL SHKNEYLHIY GKGTPRPGRK
360
MGHYTKLSRR IF
Length:362
Mass (Da):40,022
Last modified:September 21, 2011 - v1
Checksum:i31465C539901EFFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002865 Genomic DNA. Translation: AEI38534.1.
RefSeqiYP_004662824.1. NC_015709.1.

Genome annotation databases

EnsemblBacteriaiAEI38534; AEI38534; Zymop_1645.
GeneIDi10883612.
KEGGizmp:Zymop_1645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002865 Genomic DNA. Translation: AEI38534.1 .
RefSeqi YP_004662824.1. NC_015709.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI38534 ; AEI38534 ; Zymop_1645 .
GeneIDi 10883612.
KEGGi zmp:Zymop_1645.

Phylogenomic databases

KOi K01589.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00942 .
BioCyci ZMOB579138:GJDN-1708-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02222. ATP-grasp. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01161. purK. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the ethanol-producing Zymomonas mobilis subsp. pomaceae lectotype strain ATCC 29192."
    Kouvelis V.N., Davenport K.W., Brettin T.S., Bruce D., Detter C., Han C.S., Nolan M., Tapia R., Damoulaki A., Kyrpides N.C., Typas M.A., Pappas K.M.
    J. Bacteriol. 193:5049-5050(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29192 / JCM 10191 / NBRC 13757 / NCIMB 11200 / NRRL B-4491Imported.

Entry informationi

Entry nameiF8EWC4_ZYMMT
AccessioniPrimary (citable) accession number: F8EWC4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 26, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3