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F8EN42

- F8EN42_RUNSL

UniProt

F8EN42 - F8EN42_RUNSL

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Protein
Submitted name:

D-alanine--D-alanine ligase

Gene
Runsl_3158
Organism
Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.SAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.SAAS annotations

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotations, Peptidoglycan synthesisSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotations, MagnesiumSAAS annotations, ManganeseSAAS annotations, Metal-bindingSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSLI761193:GHKZ-3181-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Submitted name:
D-alanine--D-alanine ligaseImported (EC:6.3.2.4Imported)
Gene namesi
Ordered Locus Names:Runsl_3158Imported
OrganismiRunella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)Imported
Taxonomic identifieri761193 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeRunella
ProteomesiUP000000493: Chromosome

Subcellular locationi

Cytoplasm By similarity SAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

KOiK01921.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8EN42-1 [UniParc]FASTAAdd to Basket

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MRIGIFFGGP AREREISYAG GKTAYENMDK ALFTPVLVFV DSLGNFILTD    50
ESTLYHSGIR AFYPGPAFRE GGFEVYIESL QQQLSPAELE ALMHGIGTPI 100
QPQDFKKYFD FAFIILHGPD CEDGAIQGLM EWHKMPYMGP GLLGSAVSID 150
KILQNEQIAR ANGQEKKMAV VRWEEWHGAD ISQKFEEAKA AVGLPIVVKA 200
PHQGSSIGVA IVKEDSADAF AKAVNQCFFS LEIRADDWRS WSEAEKHTFA 250
QRIGNLDESI GYPVVIQETQ ETIYHPLDLL DKLDASLHSS FTLLSINAED 300
QVLLEEFMTG QEFSCGVIQD NDGTVIALPP TEIAKMDENQ TFDFKTKYKL 350
NVTRKFIPVR TALENNQKIQ YNIALVFEKL GMNAVARIDG FLTPDGRVLL 400
HDPNTLPGMS PTSLIFKQMA EIGLDVTHAI TYLIRQSLRE RIRTGKDTIH 450
LRKLLSTLDA DIAQKLAERT LQNVEFEATT EAYMEARRTF SQLSASGKVK 500
PTAVLKISDD EKHELPVGLL FKDTIEDVLE MVAQPVHPLI TETREKAKNI 550
TRRFVG 556
Length:556
Mass (Da):62,244
Last modified:September 21, 2011 - v1
Checksum:i4E44F7725A539D38
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002859 Genomic DNA. Translation: AEI49539.1.
RefSeqiWP_013928846.1. NC_015703.1.
YP_004656671.1. NC_015703.1.

Genome annotation databases

EnsemblBacteriaiAEI49539; AEI49539; Runsl_3158.
GeneIDi10871690.
KEGGirsi:Runsl_3158.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002859 Genomic DNA. Translation: AEI49539.1 .
RefSeqi WP_013928846.1. NC_015703.1.
YP_004656671.1. NC_015703.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI49539 ; AEI49539 ; Runsl_3158 .
GeneIDi 10871690.
KEGGi rsi:Runsl_3158.

Phylogenomic databases

KOi K01921.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci RSLI761193:GHKZ-3181-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4.

Entry informationi

Entry nameiF8EN42_RUNSL
AccessioniPrimary (citable) accession number: F8EN42
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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