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F8EN42

- F8EN42_RUNSL

UniProt

F8EN42 - F8EN42_RUNSL

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Protein
Submitted name:

D-alanine--D-alanine ligase

Gene

Runsl_3158

Organism
Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Note: Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSLI761193:GHKZ-3181-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Submitted name:
D-alanine--D-alanine ligaseImported (EC:6.3.2.4Imported)
Gene namesi
Ordered Locus Names:Runsl_3158Imported
OrganismiRunella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)Imported
Taxonomic identifieri761193 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeRunella
ProteomesiUP000000493: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

KOiK01921.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8EN42-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIGIFFGGP AREREISYAG GKTAYENMDK ALFTPVLVFV DSLGNFILTD
60 70 80 90 100
ESTLYHSGIR AFYPGPAFRE GGFEVYIESL QQQLSPAELE ALMHGIGTPI
110 120 130 140 150
QPQDFKKYFD FAFIILHGPD CEDGAIQGLM EWHKMPYMGP GLLGSAVSID
160 170 180 190 200
KILQNEQIAR ANGQEKKMAV VRWEEWHGAD ISQKFEEAKA AVGLPIVVKA
210 220 230 240 250
PHQGSSIGVA IVKEDSADAF AKAVNQCFFS LEIRADDWRS WSEAEKHTFA
260 270 280 290 300
QRIGNLDESI GYPVVIQETQ ETIYHPLDLL DKLDASLHSS FTLLSINAED
310 320 330 340 350
QVLLEEFMTG QEFSCGVIQD NDGTVIALPP TEIAKMDENQ TFDFKTKYKL
360 370 380 390 400
NVTRKFIPVR TALENNQKIQ YNIALVFEKL GMNAVARIDG FLTPDGRVLL
410 420 430 440 450
HDPNTLPGMS PTSLIFKQMA EIGLDVTHAI TYLIRQSLRE RIRTGKDTIH
460 470 480 490 500
LRKLLSTLDA DIAQKLAERT LQNVEFEATT EAYMEARRTF SQLSASGKVK
510 520 530 540 550
PTAVLKISDD EKHELPVGLL FKDTIEDVLE MVAQPVHPLI TETREKAKNI

TRRFVG
Length:556
Mass (Da):62,244
Last modified:September 21, 2011 - v1
Checksum:i4E44F7725A539D38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002859 Genomic DNA. Translation: AEI49539.1.
RefSeqiWP_013928846.1. NC_015703.1.
YP_004656671.1. NC_015703.1.

Genome annotation databases

EnsemblBacteriaiAEI49539; AEI49539; Runsl_3158.
GeneIDi10871690.
KEGGirsi:Runsl_3158.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002859 Genomic DNA. Translation: AEI49539.1 .
RefSeqi WP_013928846.1. NC_015703.1.
YP_004656671.1. NC_015703.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI49539 ; AEI49539 ; Runsl_3158 .
GeneIDi 10871690.
KEGGi rsi:Runsl_3158.

Phylogenomic databases

KOi K01921.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci RSLI761193:GHKZ-3181-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4Imported.

Entry informationi

Entry nameiF8EN42_RUNSL
AccessioniPrimary (citable) accession number: F8EN42
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 26, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3