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F8EN42

- F8EN42_RUNSL

UniProt

F8EN42 - F8EN42_RUNSL

Protein
Submitted name:

D-alanine--D-alanine ligase

Gene

Runsl_3158

Organism
Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Cell wall formation.SAAS annotation

    Catalytic activityi

    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.SAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseSAAS annotationImported

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRSLI761193:GHKZ-3181-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    D-alanine--D-alanine ligaseImported (EC:6.3.2.4Imported)
    Gene namesi
    Ordered Locus Names:Runsl_3158Imported
    OrganismiRunella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)Imported
    Taxonomic identifieri761193 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeRunella
    ProteomesiUP000000493: Chromosome

    Subcellular locationi

    Cytoplasm SAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains ATP-grasp domain.SAAS annotation

    Phylogenomic databases

    KOiK01921.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR23132. PTHR23132. 1 hit.
    PfamiPF07478. Dala_Dala_lig_C. 2 hits.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8EN42-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIGIFFGGP AREREISYAG GKTAYENMDK ALFTPVLVFV DSLGNFILTD    50
    ESTLYHSGIR AFYPGPAFRE GGFEVYIESL QQQLSPAELE ALMHGIGTPI 100
    QPQDFKKYFD FAFIILHGPD CEDGAIQGLM EWHKMPYMGP GLLGSAVSID 150
    KILQNEQIAR ANGQEKKMAV VRWEEWHGAD ISQKFEEAKA AVGLPIVVKA 200
    PHQGSSIGVA IVKEDSADAF AKAVNQCFFS LEIRADDWRS WSEAEKHTFA 250
    QRIGNLDESI GYPVVIQETQ ETIYHPLDLL DKLDASLHSS FTLLSINAED 300
    QVLLEEFMTG QEFSCGVIQD NDGTVIALPP TEIAKMDENQ TFDFKTKYKL 350
    NVTRKFIPVR TALENNQKIQ YNIALVFEKL GMNAVARIDG FLTPDGRVLL 400
    HDPNTLPGMS PTSLIFKQMA EIGLDVTHAI TYLIRQSLRE RIRTGKDTIH 450
    LRKLLSTLDA DIAQKLAERT LQNVEFEATT EAYMEARRTF SQLSASGKVK 500
    PTAVLKISDD EKHELPVGLL FKDTIEDVLE MVAQPVHPLI TETREKAKNI 550
    TRRFVG 556
    Length:556
    Mass (Da):62,244
    Last modified:September 21, 2011 - v1
    Checksum:i4E44F7725A539D38
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002859 Genomic DNA. Translation: AEI49539.1.
    RefSeqiWP_013928846.1. NC_015703.1.
    YP_004656671.1. NC_015703.1.

    Genome annotation databases

    EnsemblBacteriaiAEI49539; AEI49539; Runsl_3158.
    GeneIDi10871690.
    KEGGirsi:Runsl_3158.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002859 Genomic DNA. Translation: AEI49539.1 .
    RefSeqi WP_013928846.1. NC_015703.1.
    YP_004656671.1. NC_015703.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEI49539 ; AEI49539 ; Runsl_3158 .
    GeneIDi 10871690.
    KEGGi rsi:Runsl_3158.

    Phylogenomic databases

    KOi K01921.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci RSLI761193:GHKZ-3181-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR23132. PTHR23132. 1 hit.
    Pfami PF07478. Dala_Dala_lig_C. 2 hits.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4Imported.

    Entry informationi

    Entry nameiF8EN42_RUNSL
    AccessioniPrimary (citable) accession number: F8EN42
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3