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F8EJU9

- F8EJU9_RUNSL

UniProt

F8EJU9 - F8EJU9_RUNSL

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Protein

Thymidine kinase

Gene

tdk

Organism
Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Proton acceptorUniRule annotation
Metal bindingi153 – 1531ZincUniRule annotation
Metal bindingi156 – 1561ZincUniRule annotation
Metal bindingi185 – 1851ZincUniRule annotation
Metal bindingi188 – 1881ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318ATPUniRule annotation
Nucleotide bindingi96 – 994ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRSLI761193:GHKZ-911-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Runsl_0903Imported
OrganismiRunella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)Imported
Taxonomic identifieri761193 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeRunella
ProteomesiUP000000493: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8EJU9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFIEPNHNSK NSQPRIGWVE VVCGSMFSGK TEELIRRLNR AKIARQKVEI
60 70 80 90 100
FKPAIDKRYH DVDIVSHNEN SIRSTPVNTS EEILLFAGDC DVVGIDEAQF
110 120 130 140 150
LDNNLVEVCN KLAGSGKRVI VAGLDMDFAG KPFGPMPLLL SIAEYVTKVH
160 170 180 190
AVCVVCGEVA QYSYRKVTSQ DKILLGETDS YEARCRRCYT LGELA
Length:195
Mass (Da):21,742
Last modified:September 21, 2011 - v1
Checksum:i25F9E682AAA9196B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002859 Genomic DNA. Translation: AEI47340.1.
RefSeqiYP_004654472.1. NC_015703.1.

Genome annotation databases

EnsemblBacteriaiAEI47340; AEI47340; Runsl_0903.
GeneIDi10869420.
KEGGirsi:Runsl_0903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002859 Genomic DNA. Translation: AEI47340.1 .
RefSeqi YP_004654472.1. NC_015703.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI47340 ; AEI47340 ; Runsl_0903 .
GeneIDi 10869420.
KEGGi rsi:Runsl_0903.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci RSLI761193:GHKZ-911-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4Imported.

Entry informationi

Entry nameiF8EJU9_RUNSL
AccessioniPrimary (citable) accession number: F8EJU9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: October 29, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3