Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thymidine kinase

Gene

tdk

Organism
Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei97Proton acceptorUniRule annotation1
Metal bindingi153ZincUniRule annotation1
Metal bindingi156ZincUniRule annotation1
Metal bindingi185ZincUniRule annotation1
Metal bindingi188ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31ATPUniRule annotation8
Nucleotide bindingi96 – 99ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Runsl_0903Imported
OrganismiRunella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)Imported
Taxonomic identifieri761193 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeRunella
Proteomesi
  • UP000000493 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi761193.Runsl_0903.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T8J. Bacteria.
COG1435. LUCA.
KOiK00857.
OMAiKEQFGWI.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

F8EJU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIEPNHNSK NSQPRIGWVE VVCGSMFSGK TEELIRRLNR AKIARQKVEI
60 70 80 90 100
FKPAIDKRYH DVDIVSHNEN SIRSTPVNTS EEILLFAGDC DVVGIDEAQF
110 120 130 140 150
LDNNLVEVCN KLAGSGKRVI VAGLDMDFAG KPFGPMPLLL SIAEYVTKVH
160 170 180 190
AVCVVCGEVA QYSYRKVTSQ DKILLGETDS YEARCRRCYT LGELA
Length:195
Mass (Da):21,742
Last modified:September 21, 2011 - v1
Checksum:i25F9E682AAA9196B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002859 Genomic DNA. Translation: AEI47340.1.
RefSeqiWP_013926660.1. NC_015703.1.

Genome annotation databases

EnsemblBacteriaiAEI47340; AEI47340; Runsl_0903.
KEGGirsi:Runsl_0903.
PATRICifig|761193.3.peg.953.

Similar proteinsi

Entry informationi

Entry nameiF8EJU9_RUNSL
AccessioniPrimary (citable) accession number: F8EJU9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 27, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported