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F8EJU9

- F8EJU9_RUNSL

UniProt

F8EJU9 - F8EJU9_RUNSL

Protein

Thymidine kinase

Gene

tdk

Organism
Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei97 – 971Proton acceptorUniRule annotation
    Metal bindingi153 – 1531ZincUniRule annotation
    Metal bindingi156 – 1561ZincUniRule annotation
    Metal bindingi185 – 1851ZincUniRule annotation
    Metal bindingi188 – 1881ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 318ATPUniRule annotation
    Nucleotide bindingi96 – 994ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciRSLI761193:GHKZ-911-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:Runsl_0903Imported
    OrganismiRunella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)Imported
    Taxonomic identifieri761193 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeRunella
    ProteomesiUP000000493: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8EJU9-1 [UniParc]FASTAAdd to Basket

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    MFIEPNHNSK NSQPRIGWVE VVCGSMFSGK TEELIRRLNR AKIARQKVEI    50
    FKPAIDKRYH DVDIVSHNEN SIRSTPVNTS EEILLFAGDC DVVGIDEAQF 100
    LDNNLVEVCN KLAGSGKRVI VAGLDMDFAG KPFGPMPLLL SIAEYVTKVH 150
    AVCVVCGEVA QYSYRKVTSQ DKILLGETDS YEARCRRCYT LGELA 195
    Length:195
    Mass (Da):21,742
    Last modified:September 21, 2011 - v1
    Checksum:i25F9E682AAA9196B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002859 Genomic DNA. Translation: AEI47340.1.
    RefSeqiYP_004654472.1. NC_015703.1.

    Genome annotation databases

    EnsemblBacteriaiAEI47340; AEI47340; Runsl_0903.
    GeneIDi10869420.
    KEGGirsi:Runsl_0903.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002859 Genomic DNA. Translation: AEI47340.1 .
    RefSeqi YP_004654472.1. NC_015703.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEI47340 ; AEI47340 ; Runsl_0903 .
    GeneIDi 10869420.
    KEGGi rsi:Runsl_0903.

    Phylogenomic databases

    KOi K00857.

    Enzyme and pathway databases

    BioCyci RSLI761193:GHKZ-911-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4Imported.

    Entry informationi

    Entry nameiF8EJU9_RUNSL
    AccessioniPrimary (citable) accession number: F8EJU9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3