Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alanine racemase

Gene

alr

Organism
Corynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei148 – 1481SubstrateUniRule annotation
Active sitei281 – 2811Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei329 – 3291Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCRES662755:GIVW-1860-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CRES_1823Imported
OrganismiCorynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026)Imported
Taxonomic identifieri662755 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
ProteomesiUP000000492 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi662755.CRES_1823.

Structurei

3D structure databases

ProteinModelPortaliF8E1W3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiAPITAWM.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR027417. P-loop_NTPase.
IPR029066. PLP-binding_barrel.
IPR003442. T6A_TsaE.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF02367. UPF0079. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
TIGR00150. T6A_YjeE. 1 hit.

Sequencei

Sequence statusi: Complete.

F8E1W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQPLPVPAE HALAEVIIDL SAVRSNVSLF ADAAPSAEVM AVVKADAYNH
60 70 80 90 100
GAFSVARACL ESGATQLGVA TIGEALSLRT AGITAPITAW MWIPGEDLSR
110 120 130 140 150
AIQQDITIGV PSLAHAEALV ELVDTLEQSD SNSTPIAISL MADTGLSRSG
160 170 180 190 200
ITPDQWATVV ELIAKYSASF DVRGVMSHLA SADDSARAAF TDVQNRRFQR
210 220 230 240 250
AIEICREHGI DPRTNHIANT PAALTRPDLH HQMVRPGVGI YGIDPVVGGS
260 270 280 290 300
GGNAGQLRPA ITFRAKVITT KTIRAGESVS YGGTWTATRD TRTAVVAAGY
310 320 330 340 350
ADGVPRAASG KFHVGIGGKL YPQIGRVCMD QIVVNLGDSE EPTDVKPGDW
360 370 380 390 400
ATIFGEGGIS ASELAAAAET IDYEILTMPR GPRVWRRWVG EEKEQLDLSH
410 420 430 440 450
SNGHATASTS EDMVEAGRRI GEQLEAGTVV VLTGPLGAGK TTLTQGLAAG
460 470 480 490 500
LEVKGRVQSP TFTIVRTHKP SGSGRPGMLH MDAYRLLGAD VSEGVEPGKH
510 520 530 540 550
VDRDVVLDAL ESLDIDSDLD QVVVIAEWGR GVVETLSDKV LDIEIDRAAD

ERILRWEWK
Length:559
Mass (Da):59,434
Last modified:September 21, 2011 - v1
Checksum:iA6BA8CD311A5C523
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002857 Genomic DNA. Translation: AEI10176.1.
RefSeqiWP_013889163.1. NC_015673.1.
YP_004606340.1. NC_015673.1.

Genome annotation databases

EnsemblBacteriaiAEI10176; AEI10176; CRES_1823.
KEGGicrd:CRES_1823.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002857 Genomic DNA. Translation: AEI10176.1.
RefSeqiWP_013889163.1. NC_015673.1.
YP_004606340.1. NC_015673.1.

3D structure databases

ProteinModelPortaliF8E1W3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi662755.CRES_1823.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEI10176; AEI10176; CRES_1823.
KEGGicrd:CRES_1823.

Phylogenomic databases

KOiK01775.
OMAiAPITAWM.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciCRES662755:GIVW-1860-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR027417. P-loop_NTPase.
IPR029066. PLP-binding_barrel.
IPR003442. T6A_TsaE.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF02367. UPF0079. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
TIGR00150. T6A_YjeE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient."
    Schroder J., Maus I., Meyer K., Wordemann S., Blom J., Jaenicke S., Schneider J., Trost E., Tauch A.
    BMC Genomics 13:141-141(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 45100 / JCM 12819 / GTC 2026Imported.

Entry informationi

Entry nameiF8E1W3_CORRG
AccessioniPrimary (citable) accession number: F8E1W3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 24, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.