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Protein

Alanine racemase

Gene

alr

Organism
Corynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei148SubstrateUniRule annotation1
Active sitei281Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei329Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCRES662755:G1GPP-1889-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CRES_1823Imported
OrganismiCorynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026)Imported
Taxonomic identifieri662755 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi662755.CRES_1823

Structurei

3D structure databases

ProteinModelPortaliF8E1W3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini260 – 389Ala_racemase_CInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
COG0802 LUCA
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR027417 P-loop_NTPase
IPR029066 PLP-binding_barrel
IPR003442 T6A_TsaE
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PF02367 TsaE, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
TIGR00150 T6A_YjeE, 1 hit

Sequencei

Sequence statusi: Complete.

F8E1W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQPLPVPAE HALAEVIIDL SAVRSNVSLF ADAAPSAEVM AVVKADAYNH
60 70 80 90 100
GAFSVARACL ESGATQLGVA TIGEALSLRT AGITAPITAW MWIPGEDLSR
110 120 130 140 150
AIQQDITIGV PSLAHAEALV ELVDTLEQSD SNSTPIAISL MADTGLSRSG
160 170 180 190 200
ITPDQWATVV ELIAKYSASF DVRGVMSHLA SADDSARAAF TDVQNRRFQR
210 220 230 240 250
AIEICREHGI DPRTNHIANT PAALTRPDLH HQMVRPGVGI YGIDPVVGGS
260 270 280 290 300
GGNAGQLRPA ITFRAKVITT KTIRAGESVS YGGTWTATRD TRTAVVAAGY
310 320 330 340 350
ADGVPRAASG KFHVGIGGKL YPQIGRVCMD QIVVNLGDSE EPTDVKPGDW
360 370 380 390 400
ATIFGEGGIS ASELAAAAET IDYEILTMPR GPRVWRRWVG EEKEQLDLSH
410 420 430 440 450
SNGHATASTS EDMVEAGRRI GEQLEAGTVV VLTGPLGAGK TTLTQGLAAG
460 470 480 490 500
LEVKGRVQSP TFTIVRTHKP SGSGRPGMLH MDAYRLLGAD VSEGVEPGKH
510 520 530 540 550
VDRDVVLDAL ESLDIDSDLD QVVVIAEWGR GVVETLSDKV LDIEIDRAAD

ERILRWEWK
Length:559
Mass (Da):59,434
Last modified:September 21, 2011 - v1
Checksum:iA6BA8CD311A5C523
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002857 Genomic DNA Translation: AEI10176.1
RefSeqiWP_013889163.1, NC_015673.1

Genome annotation databases

EnsemblBacteriaiAEI10176; AEI10176; CRES_1823
KEGGicrd:CRES_1823

Entry informationi

Entry nameiF8E1W3_CORRG
AccessioniPrimary (citable) accession number: F8E1W3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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