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F8E1W3

- F8E1W3_CORRG

UniProt

F8E1W3 - F8E1W3_CORRG

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Protein

Alanine racemase

Gene

alr

Organism
Corynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei148 – 1481SubstrateUniRule annotation
Active sitei281 – 2811Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei329 – 3291Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
  2. threonylcarbamoyladenosine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCRES662755:GIVW-1860-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CRES_1823Imported
OrganismiCorynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026)Imported
Taxonomic identifieri662755 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000492: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF8E1W3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiNFFVAHI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR027417. P-loop_NTPase.
IPR029066. PLP-binding_barrel.
IPR003442. T6A_TsaE.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF02367. UPF0079. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
TIGR00150. T6A_YjeE. 1 hit.

Sequencei

Sequence statusi: Complete.

F8E1W3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYQPLPVPAE HALAEVIIDL SAVRSNVSLF ADAAPSAEVM AVVKADAYNH
60 70 80 90 100
GAFSVARACL ESGATQLGVA TIGEALSLRT AGITAPITAW MWIPGEDLSR
110 120 130 140 150
AIQQDITIGV PSLAHAEALV ELVDTLEQSD SNSTPIAISL MADTGLSRSG
160 170 180 190 200
ITPDQWATVV ELIAKYSASF DVRGVMSHLA SADDSARAAF TDVQNRRFQR
210 220 230 240 250
AIEICREHGI DPRTNHIANT PAALTRPDLH HQMVRPGVGI YGIDPVVGGS
260 270 280 290 300
GGNAGQLRPA ITFRAKVITT KTIRAGESVS YGGTWTATRD TRTAVVAAGY
310 320 330 340 350
ADGVPRAASG KFHVGIGGKL YPQIGRVCMD QIVVNLGDSE EPTDVKPGDW
360 370 380 390 400
ATIFGEGGIS ASELAAAAET IDYEILTMPR GPRVWRRWVG EEKEQLDLSH
410 420 430 440 450
SNGHATASTS EDMVEAGRRI GEQLEAGTVV VLTGPLGAGK TTLTQGLAAG
460 470 480 490 500
LEVKGRVQSP TFTIVRTHKP SGSGRPGMLH MDAYRLLGAD VSEGVEPGKH
510 520 530 540 550
VDRDVVLDAL ESLDIDSDLD QVVVIAEWGR GVVETLSDKV LDIEIDRAAD

ERILRWEWK
Length:559
Mass (Da):59,434
Last modified:September 21, 2011 - v1
Checksum:iA6BA8CD311A5C523
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002857 Genomic DNA. Translation: AEI10176.1.
RefSeqiYP_004606340.1. NC_015673.1.

Genome annotation databases

EnsemblBacteriaiAEI10176; AEI10176; CRES_1823.
GeneIDi10818552.
KEGGicrd:CRES_1823.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002857 Genomic DNA. Translation: AEI10176.1 .
RefSeqi YP_004606340.1. NC_015673.1.

3D structure databases

ProteinModelPortali F8E1W3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI10176 ; AEI10176 ; CRES_1823 .
GeneIDi 10818552.
KEGGi crd:CRES_1823.

Phylogenomic databases

KOi K01775.
OMAi NFFVAHI.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci CRES662755:GIVW-1860-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR027417. P-loop_NTPase.
IPR029066. PLP-binding_barrel.
IPR003442. T6A_TsaE.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF02367. UPF0079. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
TIGR00150. T6A_YjeE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient."
    Schroder J., Maus I., Meyer K., Wordemann S., Blom J., Jaenicke S., Schneider J., Trost E., Tauch A.
    BMC Genomics 13:141-141(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 45100 / JCM 12819 / GTC 2026Imported.

Entry informationi

Entry nameiF8E1W3_CORRG
AccessioniPrimary (citable) accession number: F8E1W3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: October 29, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3