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F8E1W3

- F8E1W3_CORRG

UniProt

F8E1W3 - F8E1W3_CORRG

Protein

Alanine racemase

Gene

alr

Organism
Corynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei44 – 441Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei148 – 1481SubstrateUniRule annotation
    Active sitei281 – 2811Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei329 – 3291Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
    2. threonylcarbamoyladenosine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCRES662755:GIVW-1860-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:CRES_1823Imported
    OrganismiCorynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026)Imported
    Taxonomic identifieri662755 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000492: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei44 – 441N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF8E1W3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.
    OMAiNFFVAHI.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR027417. P-loop_NTPase.
    IPR029066. PLP-binding_barrel.
    IPR003442. T6A_TsaE.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    PF02367. UPF0079. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    TIGR00150. T6A_YjeE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F8E1W3-1 [UniParc]FASTAAdd to Basket

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    MYQPLPVPAE HALAEVIIDL SAVRSNVSLF ADAAPSAEVM AVVKADAYNH    50
    GAFSVARACL ESGATQLGVA TIGEALSLRT AGITAPITAW MWIPGEDLSR 100
    AIQQDITIGV PSLAHAEALV ELVDTLEQSD SNSTPIAISL MADTGLSRSG 150
    ITPDQWATVV ELIAKYSASF DVRGVMSHLA SADDSARAAF TDVQNRRFQR 200
    AIEICREHGI DPRTNHIANT PAALTRPDLH HQMVRPGVGI YGIDPVVGGS 250
    GGNAGQLRPA ITFRAKVITT KTIRAGESVS YGGTWTATRD TRTAVVAAGY 300
    ADGVPRAASG KFHVGIGGKL YPQIGRVCMD QIVVNLGDSE EPTDVKPGDW 350
    ATIFGEGGIS ASELAAAAET IDYEILTMPR GPRVWRRWVG EEKEQLDLSH 400
    SNGHATASTS EDMVEAGRRI GEQLEAGTVV VLTGPLGAGK TTLTQGLAAG 450
    LEVKGRVQSP TFTIVRTHKP SGSGRPGMLH MDAYRLLGAD VSEGVEPGKH 500
    VDRDVVLDAL ESLDIDSDLD QVVVIAEWGR GVVETLSDKV LDIEIDRAAD 550
    ERILRWEWK 559
    Length:559
    Mass (Da):59,434
    Last modified:September 21, 2011 - v1
    Checksum:iA6BA8CD311A5C523
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002857 Genomic DNA. Translation: AEI10176.1.
    RefSeqiYP_004606340.1. NC_015673.1.

    Genome annotation databases

    EnsemblBacteriaiAEI10176; AEI10176; CRES_1823.
    GeneIDi10818552.
    KEGGicrd:CRES_1823.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002857 Genomic DNA. Translation: AEI10176.1 .
    RefSeqi YP_004606340.1. NC_015673.1.

    3D structure databases

    ProteinModelPortali F8E1W3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEI10176 ; AEI10176 ; CRES_1823 .
    GeneIDi 10818552.
    KEGGi crd:CRES_1823.

    Phylogenomic databases

    KOi K01775.
    OMAi NFFVAHI.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci CRES662755:GIVW-1860-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR027417. P-loop_NTPase.
    IPR029066. PLP-binding_barrel.
    IPR003442. T6A_TsaE.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    PF02367. UPF0079. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    TIGR00150. T6A_YjeE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient."
      Schroder J., Maus I., Meyer K., Wordemann S., Blom J., Jaenicke S., Schneider J., Trost E., Tauch A.
      BMC Genomics 13:141-141(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 45100 / JCM 12819 / GTC 2026Imported.

    Entry informationi

    Entry nameiF8E1W3_CORRG
    AccessioniPrimary (citable) accession number: F8E1W3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3