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F8E1W3

- F8E1W3_CORRG

UniProt

F8E1W3 - F8E1W3_CORRG

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Protein
Alanine racemase
Gene
alr, CRES_1823
Organism
Corynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei148 – 1481Substrate By similarityUniRule annotation
Active sitei281 – 2811Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei329 – 3291Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
  2. threonylcarbamoyladenosine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCRES662755:GIVW-1860-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CRES_1823Imported
OrganismiCorynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026)Imported
Taxonomic identifieri662755 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000492: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF8E1W3.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiNFFVAHI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR027417. P-loop_NTPase.
IPR029066. PLP-binding_barrel.
IPR003442. T6A_TsaE.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF02367. UPF0079. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
TIGR00150. T6A_YjeE. 1 hit.

Sequencei

Sequence statusi: Complete.

F8E1W3-1 [UniParc]FASTAAdd to Basket

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MYQPLPVPAE HALAEVIIDL SAVRSNVSLF ADAAPSAEVM AVVKADAYNH    50
GAFSVARACL ESGATQLGVA TIGEALSLRT AGITAPITAW MWIPGEDLSR 100
AIQQDITIGV PSLAHAEALV ELVDTLEQSD SNSTPIAISL MADTGLSRSG 150
ITPDQWATVV ELIAKYSASF DVRGVMSHLA SADDSARAAF TDVQNRRFQR 200
AIEICREHGI DPRTNHIANT PAALTRPDLH HQMVRPGVGI YGIDPVVGGS 250
GGNAGQLRPA ITFRAKVITT KTIRAGESVS YGGTWTATRD TRTAVVAAGY 300
ADGVPRAASG KFHVGIGGKL YPQIGRVCMD QIVVNLGDSE EPTDVKPGDW 350
ATIFGEGGIS ASELAAAAET IDYEILTMPR GPRVWRRWVG EEKEQLDLSH 400
SNGHATASTS EDMVEAGRRI GEQLEAGTVV VLTGPLGAGK TTLTQGLAAG 450
LEVKGRVQSP TFTIVRTHKP SGSGRPGMLH MDAYRLLGAD VSEGVEPGKH 500
VDRDVVLDAL ESLDIDSDLD QVVVIAEWGR GVVETLSDKV LDIEIDRAAD 550
ERILRWEWK 559
Length:559
Mass (Da):59,434
Last modified:September 21, 2011 - v1
Checksum:iA6BA8CD311A5C523
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002857 Genomic DNA. Translation: AEI10176.1.
RefSeqiYP_004606340.1. NC_015673.1.

Genome annotation databases

EnsemblBacteriaiAEI10176; AEI10176; CRES_1823.
GeneIDi10818552.
KEGGicrd:CRES_1823.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002857 Genomic DNA. Translation: AEI10176.1 .
RefSeqi YP_004606340.1. NC_015673.1.

3D structure databases

ProteinModelPortali F8E1W3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI10176 ; AEI10176 ; CRES_1823 .
GeneIDi 10818552.
KEGGi crd:CRES_1823.

Phylogenomic databases

KOi K01775.
OMAi NFFVAHI.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci CRES662755:GIVW-1860-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR027417. P-loop_NTPase.
IPR029066. PLP-binding_barrel.
IPR003442. T6A_TsaE.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF02367. UPF0079. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
TIGR00150. T6A_YjeE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient."
    Schroder J., Maus I., Meyer K., Wordemann S., Blom J., Jaenicke S., Schneider J., Trost E., Tauch A.
    BMC Genomics 13:141-141(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 45100 / JCM 12819 / GTC 2026.

Entry informationi

Entry nameiF8E1W3_CORRG
AccessioniPrimary (citable) accession number: F8E1W3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: July 9, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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