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Protein

Glutaminase

Gene

glsA

Organism
Corynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861SubstrateUniRule annotation
Binding sitei136 – 1361SubstrateUniRule annotation
Binding sitei182 – 1821SubstrateUniRule annotation
Binding sitei189 – 1891SubstrateUniRule annotation
Binding sitei213 – 2131SubstrateUniRule annotation
Binding sitei265 – 2651SubstrateUniRule annotation
Binding sitei283 – 2831Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCRES662755:GIVW-873-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotationSAAS annotation (EC:3.5.1.2UniRule annotationSAAS annotation)
Gene namesi
Name:glsAUniRule annotationImported
Ordered Locus Names:CRES_0853Imported
OrganismiCorynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026)Imported
Taxonomic identifieri662755 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000492 Componenti: Chromosome

PTM / Processingi

Keywords - PTMi

AcetylationUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliF8E0G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

KOiK01425.
OMAiRNMAIGY.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8E0G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLNTPERKL VKEGLISDYL RSIMADNADN SEGQTAQYIA ALRDADPEPF
60 70 80 90 100
ATALCTLDGR IYSSAYGGSF TDANVAADQV EFTIQSISKP FVYALALEEH
110 120 130 140 150
GIEELMKVVG MEPSGEAFNE LSLEGDTKRP VNPMINAGAI TVNQLINGSE
160 170 180 190 200
SSVEDRVAKI HDFMNELAGR KLMLDKQTAS SELESSDRNL ALAHMLRSYH
210 220 230 240 250
IIQDSAEDAV NSYVQQCSIK VNVRDLAVMG ATLASGGVQP LTGKRVMKQS
260 270 280 290 300
VARQVQSVMA SAGMYNAAGR WMARVGIPAK SGVAGGVLGT LPGQLGLSSF
310 320 330 340 350
SPKLDEQGNS VRGVRVFQRL SKDMGLHLMA PEPRGRASVR SLTEDESTGE
360 370 380 390 400
SIVCLQGDID FIGGERLYRT LMEHQLKHKQ LVFDLTRVDG MNSVGRKMLT
410 420
NGIELLREEG FSIRIEDPDG LLA
Length:423
Mass (Da):45,900
Last modified:September 21, 2011 - v1
Checksum:i6E507FE39BC25BCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002857 Genomic DNA. Translation: AEI09209.1.
RefSeqiYP_004605373.1. NC_015673.1.

Genome annotation databases

EnsemblBacteriaiAEI09209; AEI09209; CRES_0853.
KEGGicrd:CRES_0853.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002857 Genomic DNA. Translation: AEI09209.1.
RefSeqiYP_004605373.1. NC_015673.1.

3D structure databases

ProteinModelPortaliF8E0G8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEI09209; AEI09209; CRES_0853.
KEGGicrd:CRES_0853.

Phylogenomic databases

KOiK01425.
OMAiRNMAIGY.

Enzyme and pathway databases

BioCyciCRES662755:GIVW-873-MONOMER.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient."
    Schroder J., Maus I., Meyer K., Wordemann S., Blom J., Jaenicke S., Schneider J., Trost E., Tauch A.
    BMC Genomics 13:141-141(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 45100 / JCM 12819 / GTC 2026Imported.

Entry informationi

Entry nameiF8E0G8_CORRG
AccessioniPrimary (citable) accession number: F8E0G8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 1, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.