Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

F8DYK2 (F8DYK2_CORRG) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL AEI09667.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:CRES_1311 EMBL AEI09667.1
OrganismCorynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026) [Complete proteome] [HAMAP] EMBL AEI09667.1
Taxonomic identifier662755 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain168 – 373206ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding195 – 25056ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3271Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3401Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3401Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3421Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F8DYK2 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: DE28F7EDA239D442

FASTA37940,683
        10         20         30         40         50         60 
MNTPAADNAS VRSTATDVSA EHRIKVAVLY GGQSSEHSVS CISAGAIMDH LDPERYEVIP 

        70         80         90        100        110        120 
VGITPQGAWV PGTVDTSELR ADDREMPSVR DRGEHIQLVL GAQTGELRYV SGGHAGRTYA 

       130        140        150        160        170        180 
HVDVIFPVLH GQNGEDGTIQ GLFELAGIPY VGNGVLASAA GMDKEYTKRL AKQAGVPCGE 

       190        200        210        220        230        240 
ELILAENREL TEDEQQRLGL PVFVKPARGG SSIGISKVDT WEDFAHAVEI AFDHDNKVIV 

       250        260        270        280        290        300 
EAMIHGREVE CGVLQYPEGS VIASAPAMLE GTEDGDEGFY GFDAKYLDNT VTPSIPAPIG 

       310        320        330        340        350        360 
EEATAEVRRL AVRTFEALNC EGLARVDFFV TDSGEVILNE INTLPGFTPI SMYPQMFIAG 

       370 
GMGYPQLLDI LIARALVQD 

« Hide

References

[1]"Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient."
Schroder J., Maus I., Meyer K., Wordemann S., Blom J., Jaenicke S., Schneider J., Trost E., Tauch A.
BMC Genomics 13:141-141(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 45100 / JCM 12819 / GTC 2026.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002857 Genomic DNA. Translation: AEI09667.1.
RefSeqYP_004605831.1. NC_015673.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEI09667; AEI09667; CRES_1311.
GeneID10818036.
KEGGcrd:CRES_1311.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAMDKIAMK.

Enzyme and pathway databases

BioCycCRES662755:GIVW-1344-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8DYK2_CORRG
AccessionPrimary (citable) accession number: F8DYK2
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 19, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)