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UniProtKB - F8DRV7 (F8DRV7_LACRS)

UniProt

F8DRV7 - F8DRV7_LACRS

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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Lactobacillus reuteri (strain ATCC 55730 / SD2112)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91Tele-phosphohistidine intermediateUniRule annotation
Binding sitei60 – 601SubstrateUniRule annotation
Active sitei87 – 871Proton donor/acceptorUniRule annotation
Binding sitei98 – 981SubstrateUniRule annotation
Sitei182 – 1821Transition state stabilizerUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationImported

Keywords - Biological processi

GluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLREU491077:GH1M-1347-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotationImported
Ordered Locus Names:HMPREF0538_21299Imported
OrganismiLactobacillus reuteri (strain ATCC 55730 / SD2112)Imported
Taxonomic identifieri491077 [NCBI]
Taxonomic lineageiBacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus ›
Proteomesi
  • UP000001924 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF8DRV7.
SMRiF8DRV7. Positions 1-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 158Substrate bindingUniRule annotation
Regioni21 – 222Substrate bindingUniRule annotation
Regioni87 – 904Substrate bindingUniRule annotation
Regioni114 – 1152Substrate bindingUniRule annotation
Regioni183 – 1842Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01834.
OMAiVKNQGKK.
OrthoDBiPOG091H03E2.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 2 hits.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8DRV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLVLIRHG QSEWNLSNQF TGWVDVDLSE KGVEQAKNAG KALKEHGIEF 
        60         70         80         90        100
DYAYTSVLKR AIKTLHYALE ECDQLWIPEY KTWRLNERHY GALQGHNKQK 
       110        120        130        140        150
AAEKYGDEQV HIWRRSYDVL PPLLSADDEG SAAKDRRYAN LDPRAIPGGE 
       160        170        180        190        200
NLKVTLERVI PLWQDEIAPK LLDNKNVIIA AHGNSLRALS KYIENISDED 
       210        220 
IMNLEMATGQ PVVYDFDDKL NVLSKEKY
Length:228
Mass (Da):26,122
Last modified:September 21, 2011 - v1
Checksum:i713FD0E21EDF9222
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002844 Genomic DNA. Translation: AEI57509.1.
RefSeqiWP_003665449.1. NC_015697.1.

Genome annotation databases

EnsemblBacteriaiAEI57509; AEI57509; HMPREF0538_21299.
GeneIDi5189190.
KEGGilru:HMPREF0538_21299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002844 Genomic DNA. Translation: AEI57509.1.
RefSeqiWP_003665449.1. NC_015697.1.

3D structure databases

ProteinModelPortaliF8DRV7.
SMRiF8DRV7. Positions 1-225.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEI57509; AEI57509; HMPREF0538_21299.
GeneIDi5189190.
KEGGilru:HMPREF0538_21299.

Phylogenomic databases

KOiK01834.
OMAiVKNQGKK.
OrthoDBiPOG091H03E2.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.
BioCyciLREU491077:GH1M-1347-MONOMER.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 2 hits.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF8DRV7_LACRS
AccessioniPrimary (citable) accession number: F8DRV7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 7, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.