gpmA

Functionⁱ

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityⁱ

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayⁱ: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:

no protein annotated in this organism
Phosphoglycerate kinase (pgk)
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
Enolase (eno)
Pyruvate kinase (pyk)

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	9	Tele-phosphohistidine intermediateUniRule annotation	1
Binding siteⁱ	60	SubstrateUniRule annotation	1
Active siteⁱ	87	Proton donor/acceptorUniRule annotation	1
Binding siteⁱ	98	SubstrateUniRule annotation	1
Siteⁱ	182	Transition state stabilizerUniRule annotation	1

GO - Molecular functionⁱ

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

gluconeogenesis Source: UniProtKB-UniRule
glycolytic process Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	IsomeraseUniRule annotationSAAS annotationImported
Biological process	GluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00186.

UniPathwayⁱ

UPA00109; UER00186.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation) Short name: BPG-dependent PGAMUniRule annotation Short name: PGAMUniRule annotation Short name: PhosphoglyceromutaseUniRule annotation Short name: dPGMUniRule annotation
Gene namesⁱ	Name:gpmAUniRule annotationImported Ordered Locus Names:HMPREF0538_21299Imported
Organismⁱ	Lactobacillus reuteri (strain ATCC 55730 / SD2112)Imported
Taxonomic identifierⁱ	491077 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus reuteri
Proteomesⁱ	UP000001924 Componentⁱ: Chromosome

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F8DRV7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	8 – 15	Substrate bindingUniRule annotation	8
Regionⁱ	21 – 22	Substrate bindingUniRule annotation	2
Regionⁱ	87 – 90	Substrate bindingUniRule annotation	4
Regionⁱ	114 – 115	Substrate bindingUniRule annotation	2
Regionⁱ	183 – 184	Substrate bindingUniRule annotation	2

Sequence similaritiesⁱ

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K01834.
OMAⁱ	RMLPYWY.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H03E2.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07067. HP_PGM_like. 1 hit.
Gene3Dⁱ	3.40.50.1240. 1 hit.
HAMAPⁱ	MF_01039. PGAM_GpmA. 1 hit.
InterProⁱ	View protein in InterPro IPR013078. His_Pase_superF_clade-1. IPR029033. His_PPase_superfam. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1.
PANTHERⁱ	PTHR11931. PTHR11931. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00300. His_Phos_1. 2 hits.
SMARTⁱ	View protein in SMART SM00855. PGAM. 1 hit.
SUPFAMⁱ	SSF53254. SSF53254. 1 hit.
TIGRFAMsⁱ	TIGR01258. pgm_1. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00175. PG_MUTASE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

F8DRV7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAKLVLIRHG QSEWNLSNQF TGWVDVDLSE KGVEQAKNAG KALKEHGIEF 
        60         70         80         90        100
DYAYTSVLKR AIKTLHYALE ECDQLWIPEY KTWRLNERHY GALQGHNKQK 
       110        120        130        140        150
AAEKYGDEQV HIWRRSYDVL PPLLSADDEG SAAKDRRYAN LDPRAIPGGE 
       160        170        180        190        200
NLKVTLERVI PLWQDEIAPK LLDNKNVIIA AHGNSLRALS KYIENISDED 
       210        220 
IMNLEMATGQ PVVYDFDDKL NVLSKEKY

Length:228

Mass (Da):26,122

Last modified:September 21, 2011 - v1

Checksum:ⁱ713FD0E21EDF9222

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP002844 Genomic DNA. Translation: AEI57509.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_003665449.1. NC_015697.1.

Genome annotation databases

EnsemblBacteriaⁱ	AEI57509; AEI57509; HMPREF0538_21299.
GeneIDⁱ	5189190.
KEGGⁱ	lru:HMPREF0538_21299.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F8DRV7	F8KF14 A0A073JRM0 S5NMC2 A0A2A7QFS3 A5VHU4 B3XNP3 R9WMK0 A0A2A7R6A0 C0Z022	Lactobacillus reuteri ATCC 53608 Lactobacillus reuteri Lactobacillus reuteri TD1 Lactobacillus sp. UMNPBX18 Lactobacillus reuteri (strain DSM 20016) Lactobacillus reuteri 100-23 Lactobacillus reuteri I5007 Lactobacillus sp. UMNPBX3 Lactobacillus reuteri MM2-3	228	UniRef100_F8KF14	Cluster: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	10

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F8DRV7	A0A0F4HE83 B2GF82 A0A0N7CIV6 D0DVU2 C0WW67 V4XGV4 T0SBP4 A0A142KRU8 R4RQW6 A0A0R2EMR2 +32	Lactobacillus fermentum Lactobacillus fermentum (strain NBRC 3956 / LMG 18251) Lactobacillus fermentum 3872 Lactobacillus fermentum 28-3-CHN Lactobacillus fermentum ATCC 14931 Lactobacillus fermentum NB-22 Lactobacillus fermentum MTCC 8711 Lactobacillus oris Lactobacillus fermentum F-6 Lactobacillus coleohominis 101-4-CHN And more	231	UniRef90_A0A0F4HE83	Cluster: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	43

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F8DRV7	P82612 C4YJS4 B9WB10 M3HTG2 C5M5P5 F1YIT8 M3VEC3 UPI000781AFDF UPI0008240A5D A0A0N9NBT1 +2333	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Candida albicans (strain WO-1) (Yeast) Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast) Candida maltosa (strain Xu316) (Yeast) Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Gordonia neofelifaecis NRRL B-59395 Gordonia malaquae NBRC 108250 Gordonia sp. QH-12 Gordonia hydrophobica Gordonia phthalatica And more	248	UniRef50_P82612	Cluster: Phosphoglycerate mutase	2,344

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP002844 Genomic DNA. Translation: AEI57509.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_003665449.1. NC_015697.1.

3D structure databases

ProteinModelPortalⁱ	F8DRV7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AEI57509; AEI57509; HMPREF0538_21299.
GeneIDⁱ	5189190.
KEGGⁱ	lru:HMPREF0538_21299.

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K01834.
OMAⁱ	RMLPYWY.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H03E2.

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00186.

UniPathwayⁱ

UPA00109; UER00186.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07067. HP_PGM_like. 1 hit.
Gene3Dⁱ	3.40.50.1240. 1 hit.
HAMAPⁱ	MF_01039. PGAM_GpmA. 1 hit.
InterProⁱ	View protein in InterPro IPR013078. His_Pase_superF_clade-1. IPR029033. His_PPase_superfam. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1.
PANTHERⁱ	PTHR11931. PTHR11931. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00300. His_Phos_1. 2 hits.
SMARTⁱ	View protein in SMART SM00855. PGAM. 1 hit.
SUPFAMⁱ	SSF53254. SSF53254. 1 hit.
TIGRFAMsⁱ	TIGR01258. pgm_1. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00175. PG_MUTASE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F8DRV7_LACRS
Accessionⁱ	F8DRV7Primary (citable) accession number: F8DRV7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 21, 2011
	Last sequence update:	September 21, 2011
	Last modified:	March 28, 2018
	This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB - F8DRV7 (F8DRV7_LACRS)

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2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: glycolysis

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Region

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F8DRV7 (F8DRV7_LACRS)

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2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

gpmA

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ