UniProtKB - F8DRV7 (F8DRV7_LACRS)
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Protein
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Gene
gpmA
Organism
Lactobacillus reuteri (strain ATCC 55730 / SD2112)
Status
Functioni
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation
Catalytic activityi
2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation
: glycolysis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotationProteins known to be involved in the 5 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Phosphoglycerate kinase (pgk)
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
- Enolase (eno)
- Pyruvate kinase (pyk)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 9 | Tele-phosphohistidine intermediateUniRule annotation | 1 | |
Binding sitei | 60 | SubstrateUniRule annotation | 1 | |
Active sitei | 87 | Proton donor/acceptorUniRule annotation | 1 | |
Binding sitei | 98 | SubstrateUniRule annotation | 1 | |
Sitei | 182 | Transition state stabilizerUniRule annotation | 1 |
GO - Molecular functioni
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: UniProtKB-UniRule
GO - Biological processi
- gluconeogenesis Source: UniProtKB-UniRule
- glycolytic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | IsomeraseUniRule annotationSAAS annotationImported |
Biological process | GluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation |
Enzyme and pathway databases
UniPathwayi | UPA00109; UER00186. |
Names & Taxonomyi
Protein namesi | Recommended name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)Short name: BPG-dependent PGAMUniRule annotation Short name: PGAMUniRule annotation Short name: PhosphoglyceromutaseUniRule annotation Short name: dPGMUniRule annotation |
Gene namesi | Name:gpmAUniRule annotationImported Ordered Locus Names:HMPREF0538_21299Imported |
Organismi | Lactobacillus reuteri (strain ATCC 55730 / SD2112)Imported |
Taxonomic identifieri | 491077 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › |
Proteomesi |
|
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 8 – 15 | Substrate bindingUniRule annotation | 8 | |
Regioni | 21 – 22 | Substrate bindingUniRule annotation | 2 | |
Regioni | 87 – 90 | Substrate bindingUniRule annotation | 4 | |
Regioni | 114 – 115 | Substrate bindingUniRule annotation | 2 | |
Regioni | 183 – 184 | Substrate bindingUniRule annotation | 2 |
Sequence similaritiesi
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation
Phylogenomic databases
KOi | K01834. |
OMAi | RMLPYWY. |
OrthoDBi | POG091H03E2. |
Family and domain databases
CDDi | cd07067. HP_PGM_like. 1 hit. |
Gene3Di | 3.40.50.1240. 1 hit. |
HAMAPi | MF_01039. PGAM_GpmA. 1 hit. |
InterProi | View protein in InterPro IPR013078. His_Pase_superF_clade-1. IPR029033. His_PPase_superfam. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1. |
PANTHERi | PTHR11931. PTHR11931. 1 hit. |
Pfami | View protein in Pfam PF00300. His_Phos_1. 2 hits. |
SMARTi | View protein in SMART SM00855. PGAM. 1 hit. |
SUPFAMi | SSF53254. SSF53254. 1 hit. |
TIGRFAMsi | TIGR01258. pgm_1. 1 hit. |
PROSITEi | View protein in PROSITE PS00175. PG_MUTASE. 1 hit. |
i Sequence
Sequence statusi: Complete.
F8DRV7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKLVLIRHG QSEWNLSNQF TGWVDVDLSE KGVEQAKNAG KALKEHGIEF
60 70 80 90 100
DYAYTSVLKR AIKTLHYALE ECDQLWIPEY KTWRLNERHY GALQGHNKQK
110 120 130 140 150
AAEKYGDEQV HIWRRSYDVL PPLLSADDEG SAAKDRRYAN LDPRAIPGGE
160 170 180 190 200
NLKVTLERVI PLWQDEIAPK LLDNKNVIIA AHGNSLRALS KYIENISDED
210 220
IMNLEMATGQ PVVYDFDDKL NVLSKEKY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP002844 Genomic DNA. Translation: AEI57509.1. |
RefSeqi | WP_003665449.1. NC_015697.1. |
Genome annotation databases
EnsemblBacteriai | AEI57509; AEI57509; HMPREF0538_21299. |
GeneIDi | 5189190. |
KEGGi | lru:HMPREF0538_21299. |
Similar proteinsi
Entry informationi
Entry namei | F8DRV7_LACRS | |
Accessioni | F8DRV7Primary (citable) accession number: F8DRV7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | March 28, 2018 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |