gpmA

Functionⁱ

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityⁱ

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayⁱ: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:

no protein annotated in this organism
Phosphoglycerate kinase (pgk)
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
Enolase (eno)
Pyruvate kinase (pyk)

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	9	Tele-phosphohistidine intermediateUniRule annotation	1
Binding siteⁱ	60	SubstrateUniRule annotation	1
Active siteⁱ	87	Proton donor/acceptorUniRule annotation	1
Binding siteⁱ	98	SubstrateUniRule annotation	1
Siteⁱ	182	Transition state stabilizerUniRule annotation	1

GO - Molecular functionⁱ

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: UniProtKB-HAMAP

Complete GO annotation...

GO - Biological processⁱ

gluconeogenesis Source: UniProtKB-HAMAP
glycolytic process Source: UniProtKB-HAMAP

Complete GO annotation...

Keywordsⁱ

Molecular function	IsomeraseUniRule annotationSAAS annotationImported
Biological process	GluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00186.

UniPathwayⁱ

UPA00109; UER00186.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation) Short name: BPG-dependent PGAMUniRule annotation Short name: PGAMUniRule annotation Short name: PhosphoglyceromutaseUniRule annotation Short name: dPGMUniRule annotation
Gene namesⁱ	Name:gpmAUniRule annotationImported Ordered Locus Names:HMPREF0538_21299Imported
Organismⁱ	Lactobacillus reuteri (strain ATCC 55730 / SD2112)Imported
Taxonomic identifierⁱ	491077 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus reuteri
Proteomesⁱ	UP000001924 Componentⁱ: Chromosome

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F8DRV7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	8 – 15	Substrate bindingUniRule annotation	8
Regionⁱ	21 – 22	Substrate bindingUniRule annotation	2
Regionⁱ	87 – 90	Substrate bindingUniRule annotation	4
Regionⁱ	114 – 115	Substrate bindingUniRule annotation	2
Regionⁱ	183 – 184	Substrate bindingUniRule annotation	2

Sequence similaritiesⁱ

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K01834.
OMAⁱ	RMLPYWY.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H03E2.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07067. HP_PGM_like. 1 hit.
Gene3Dⁱ	3.40.50.1240. 1 hit.
HAMAPⁱ	MF_01039. PGAM_GpmA. 1 hit.
InterProⁱ	View protein in InterPro IPR013078. His_Pase_superF_clade-1. IPR029033. His_PPase_superfam. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1.
PANTHERⁱ	PTHR11931. PTHR11931. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00300. His_Phos_1. 2 hits.
SMARTⁱ	View protein in SMART SM00855. PGAM. 1 hit.
SUPFAMⁱ	SSF53254. SSF53254. 1 hit.
TIGRFAMsⁱ	TIGR01258. pgm_1. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00175. PG_MUTASE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

F8DRV7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAKLVLIRHG QSEWNLSNQF TGWVDVDLSE KGVEQAKNAG KALKEHGIEF 
        60         70         80         90        100
DYAYTSVLKR AIKTLHYALE ECDQLWIPEY KTWRLNERHY GALQGHNKQK 
       110        120        130        140        150
AAEKYGDEQV HIWRRSYDVL PPLLSADDEG SAAKDRRYAN LDPRAIPGGE 
       160        170        180        190        200
NLKVTLERVI PLWQDEIAPK LLDNKNVIIA AHGNSLRALS KYIENISDED 
       210        220 
IMNLEMATGQ PVVYDFDDKL NVLSKEKY

Length:228

Mass (Da):26,122

Last modified:September 21, 2011 - v1

Checksum:ⁱ713FD0E21EDF9222

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP002844 Genomic DNA. Translation: AEI57509.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_003665449.1. NC_015697.1.

Genome annotation databases

EnsemblBacteriaⁱ	AEI57509; AEI57509; HMPREF0538_21299.
GeneIDⁱ	5189190.
KEGGⁱ	lru:HMPREF0538_21299.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP002844 Genomic DNA. Translation: AEI57509.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_003665449.1. NC_015697.1.

3D structure databases

ProteinModelPortalⁱ	F8DRV7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AEI57509; AEI57509; HMPREF0538_21299.
GeneIDⁱ	5189190.
KEGGⁱ	lru:HMPREF0538_21299.

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K01834.
OMAⁱ	RMLPYWY.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H03E2.

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00186.

UniPathwayⁱ

UPA00109; UER00186.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07067. HP_PGM_like. 1 hit.
Gene3Dⁱ	3.40.50.1240. 1 hit.
HAMAPⁱ	MF_01039. PGAM_GpmA. 1 hit.
InterProⁱ	View protein in InterPro IPR013078. His_Pase_superF_clade-1. IPR029033. His_PPase_superfam. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1.
PANTHERⁱ	PTHR11931. PTHR11931. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00300. His_Phos_1. 2 hits.
SMARTⁱ	View protein in SMART SM00855. PGAM. 1 hit.
SUPFAMⁱ	SSF53254. SSF53254. 1 hit.
TIGRFAMsⁱ	TIGR01258. pgm_1. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00175. PG_MUTASE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F8DRV7_LACRS
Accessionⁱ	F8DRV7Primary (citable) accession number: F8DRV7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 21, 2011
	Last sequence update:	September 21, 2011
	Last modified:	June 7, 2017
	This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB - F8DRV7 (F8DRV7_LACRS)

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2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: glycolysis

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Region

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F8DRV7 (F8DRV7_LACRS)

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2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

gpmA

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ