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F8DNX1

- F8DNX1_LACRS

UniProt

F8DNX1 - F8DNX1_LACRS

Protein

Trigger factor

Gene

tig

Organism
Lactobacillus reuteri (strain ATCC 55730 / SD2112)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.UniRule annotation
    Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. protein folding Source: UniProtKB-HAMAP
    4. protein transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    ChaperoneUniRule annotation, Isomerase, RotamaseUniRule annotation

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation

    Enzyme and pathway databases

    BioCyciLREU491077:GH1M-2006-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
    Short name:
    TFUniRule annotation
    Alternative name(s):
    PPIaseUniRule annotation
    Gene namesi
    Name:tigUniRule annotationImported
    Ordered Locus Names:HMPREF0538_21899Imported
    OrganismiLactobacillus reuteri (strain ATCC 55730 / SD2112)Imported
    Taxonomic identifieri491077 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001924: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation
    Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF8DNX1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini164 – 24683PPIase FKBP-typeUniRule annotationAdd
    BLAST

    Domaini

    Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation
    Contains 1 PPIase FKBP-type domain.UniRule annotation

    Phylogenomic databases

    KOiK03545.
    OMAiFKVKVHE.
    OrthoDBiEOG63VBX3.

    Family and domain databases

    Gene3Di1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPiMF_00303. Trigger_factor_Tig.
    InterProiIPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view]
    PfamiPF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003095. Trigger_factor. 1 hit.
    SUPFAMiSSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsiTIGR00115. tig. 1 hit.
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8DNX1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAKWERDSD ASKGTLTFEI DVDTINKGID EAFVETRKKI TVPGFRKGRV    50
    PRQIFNQMYG EESLYQDALN KVLPDAYNEA VKETNIQPVD QPKIDIKSME 100
    KGQPWVLTAE VDVMPEVKLG EYKGMEVPAQ DTTVTDADVD DALETKRQQQ 150
    AELVLKEDKP AEKGDTVVID YKGSVDGEEF DGGSAENYSL ELGSGSFIPG 200
    FEDQLIGHNA DEDVDVNVTF PEDYHAKNLA GKDALFKVKI HEIKEKQLPE 250
    LDDDFAKDVD EDVDTLAELK EKTKKQLQEE KDNQAKAAIE DAAINKAVAN 300
    AEIQDIPQAM LDDDTNRQMQ QYLAGMQQQG ISPQMYFQIT GTKEEDLKKQ 350
    FANDAAQRVK TNLVLEAIVD DANLDATDEE IAKEISDLAK QYGMEEDAVK 400
    KALSKDMLMH DIKIRKAVDL VADSAKQVKD DEKSDK 436
    Length:436
    Mass (Da):48,747
    Last modified:September 21, 2011 - v1
    Checksum:iEF02E138E3915441
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002844 Genomic DNA. Translation: AEI58107.1.
    RefSeqiYP_004650397.1. NC_015697.1.

    Genome annotation databases

    EnsemblBacteriaiAEI58107; AEI58107; HMPREF0538_21899.
    GeneIDi10868004.
    KEGGilru:HMPREF0538_21899.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002844 Genomic DNA. Translation: AEI58107.1 .
    RefSeqi YP_004650397.1. NC_015697.1.

    3D structure databases

    ProteinModelPortali F8DNX1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEI58107 ; AEI58107 ; HMPREF0538_21899 .
    GeneIDi 10868004.
    KEGGi lru:HMPREF0538_21899.

    Phylogenomic databases

    KOi K03545.
    OMAi FKVKVHE.
    OrthoDBi EOG63VBX3.

    Enzyme and pathway databases

    BioCyci LREU491077:GH1M-2006-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPi MF_00303. Trigger_factor_Tig.
    InterProi IPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view ]
    Pfami PF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003095. Trigger_factor. 1 hit.
    SUPFAMi SSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsi TIGR00115. tig. 1 hit.
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome of Lactobacillus reuteri ATCC 55730 / SD2112."
      Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A., Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X., Perez L., Shen H., Wang Q., Watt J.
      , Xi L., Xin Y., Zhou J., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A., Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B., Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.
      Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 55730 / SD2112Imported.

    Entry informationi

    Entry nameiF8DNX1_LACRS
    AccessioniPrimary (citable) accession number: F8DNX1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3