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F8DNX1

- F8DNX1_LACRS

UniProt

F8DNX1 - F8DNX1_LACRS

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Protein
Trigger factor
Gene
tig, HMPREF0538_21899
Organism
Lactobacillus reuteri (strain ATCC 55730 / SD2112)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation By similarity.UniRule annotation
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase By similarity.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. protein folding Source: UniProtKB-HAMAP
  4. protein transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotation, Isomerase, RotamaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation

Enzyme and pathway databases

BioCyciLREU491077:GH1M-2006-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
TFUniRule annotation
Alternative name(s):
PPIase
Gene namesi
Name:tigUniRule annotationImported
Ordered Locus Names:HMPREF0538_21899Imported
OrganismiLactobacillus reuteri (strain ATCC 55730 / SD2112)Imported
Taxonomic identifieri491077 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001924: Chromosome

Subcellular locationi

Cytoplasm
Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF8DNX1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 24683PPIase FKBP-type By similarityUniRule annotation
Add
BLAST

Domaini

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own By similarity.UniRule annotation

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.UniRule annotation

Phylogenomic databases

KOiK03545.
OMAiFKVKVHE.
OrthoDBiEOG63VBX3.

Family and domain databases

Gene3Di1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPiMF_00303. Trigger_factor_Tig.
InterProiIPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003095. Trigger_factor. 1 hit.
SUPFAMiSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsiTIGR00115. tig. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8DNX1-1 [UniParc]FASTAAdd to Basket

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MSAKWERDSD ASKGTLTFEI DVDTINKGID EAFVETRKKI TVPGFRKGRV    50
PRQIFNQMYG EESLYQDALN KVLPDAYNEA VKETNIQPVD QPKIDIKSME 100
KGQPWVLTAE VDVMPEVKLG EYKGMEVPAQ DTTVTDADVD DALETKRQQQ 150
AELVLKEDKP AEKGDTVVID YKGSVDGEEF DGGSAENYSL ELGSGSFIPG 200
FEDQLIGHNA DEDVDVNVTF PEDYHAKNLA GKDALFKVKI HEIKEKQLPE 250
LDDDFAKDVD EDVDTLAELK EKTKKQLQEE KDNQAKAAIE DAAINKAVAN 300
AEIQDIPQAM LDDDTNRQMQ QYLAGMQQQG ISPQMYFQIT GTKEEDLKKQ 350
FANDAAQRVK TNLVLEAIVD DANLDATDEE IAKEISDLAK QYGMEEDAVK 400
KALSKDMLMH DIKIRKAVDL VADSAKQVKD DEKSDK 436
Length:436
Mass (Da):48,747
Last modified:September 21, 2011 - v1
Checksum:iEF02E138E3915441
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002844 Genomic DNA. Translation: AEI58107.1.
RefSeqiYP_004650397.1. NC_015697.1.

Genome annotation databases

EnsemblBacteriaiAEI58107; AEI58107; HMPREF0538_21899.
GeneIDi10868004.
KEGGilru:HMPREF0538_21899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002844 Genomic DNA. Translation: AEI58107.1 .
RefSeqi YP_004650397.1. NC_015697.1.

3D structure databases

ProteinModelPortali F8DNX1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI58107 ; AEI58107 ; HMPREF0538_21899 .
GeneIDi 10868004.
KEGGi lru:HMPREF0538_21899.

Phylogenomic databases

KOi K03545.
OMAi FKVKVHE.
OrthoDBi EOG63VBX3.

Enzyme and pathway databases

BioCyci LREU491077:GH1M-2006-MONOMER.

Family and domain databases

Gene3Di 1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPi MF_00303. Trigger_factor_Tig.
InterProi IPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view ]
Pfami PF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF003095. Trigger_factor. 1 hit.
SUPFAMi SSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsi TIGR00115. tig. 1 hit.
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome of Lactobacillus reuteri ATCC 55730 / SD2112."
    Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A., Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X., Perez L., Shen H., Wang Q., Watt J.
    , Xi L., Xin Y., Zhou J., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A., Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B., Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.
    Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 55730 / SD2112.

Entry informationi

Entry nameiF8DNX1_LACRS
AccessioniPrimary (citable) accession number: F8DNX1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: May 14, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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