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Protein

Trigger factor

Gene

tig

Organism
Lactobacillus reuteri (strain ATCC 55730 / SD2112)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotation, Isomerase, RotamaseUniRule annotation
Biological processCell cycle, Cell divisionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
TFUniRule annotation
Alternative name(s):
PPIaseUniRule annotation
Gene namesi
Name:tigUniRule annotationImported
Ordered Locus Names:HMPREF0538_21899Imported
OrganismiLactobacillus reuteri (strain ATCC 55730 / SD2112)Imported
Taxonomic identifieri491077 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001924 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF8DNX1
SMRiF8DNX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 246PPIase FKBP-typeInterPro annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili139 – 159Sequence analysisAdd BLAST21
Coiled coili256 – 290Sequence analysisAdd BLAST35

Domaini

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

Sequence similaritiesi

Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK03545
OMAiMAMIEDR
OrthoDBiPOG091H01T7

Family and domain databases

Gene3Di1.10.3120.10, 2 hits
3.30.70.1050, 1 hit
HAMAPiMF_00303 Trigger_factor_Tig, 1 hit
InterProiView protein in InterPro
IPR001179 PPIase_FKBP_dom
IPR005215 Trig_fac
IPR008880 Trigger_fac_C
IPR037041 Trigger_fac_C_sf
IPR008881 Trigger_fac_ribosome-bd_bac
IPR036611 Trigger_fac_ribosome-bd_sf
IPR027304 Trigger_fact/SurA_dom_sf
PANTHERiPTHR30560 PTHR30560, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PF05698 Trigger_C, 1 hit
PF05697 Trigger_N, 1 hit
PIRSFiPIRSF003095 Trigger_factor, 1 hit
SUPFAMiSSF102735 SSF102735, 1 hit
SSF109998 SSF109998, 1 hit
TIGRFAMsiTIGR00115 tig, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

Sequencei

Sequence statusi: Complete.

F8DNX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKWERDSD ASKGTLTFEI DVDTINKGID EAFVETRKKI TVPGFRKGRV
60 70 80 90 100
PRQIFNQMYG EESLYQDALN KVLPDAYNEA VKETNIQPVD QPKIDIKSME
110 120 130 140 150
KGQPWVLTAE VDVMPEVKLG EYKGMEVPAQ DTTVTDADVD DALETKRQQQ
160 170 180 190 200
AELVLKEDKP AEKGDTVVID YKGSVDGEEF DGGSAENYSL ELGSGSFIPG
210 220 230 240 250
FEDQLIGHNA DEDVDVNVTF PEDYHAKNLA GKDALFKVKI HEIKEKQLPE
260 270 280 290 300
LDDDFAKDVD EDVDTLAELK EKTKKQLQEE KDNQAKAAIE DAAINKAVAN
310 320 330 340 350
AEIQDIPQAM LDDDTNRQMQ QYLAGMQQQG ISPQMYFQIT GTKEEDLKKQ
360 370 380 390 400
FANDAAQRVK TNLVLEAIVD DANLDATDEE IAKEISDLAK QYGMEEDAVK
410 420 430
KALSKDMLMH DIKIRKAVDL VADSAKQVKD DEKSDK
Length:436
Mass (Da):48,747
Last modified:September 21, 2011 - v1
Checksum:iEF02E138E3915441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002844 Genomic DNA Translation: AEI58107.1
RefSeqiWP_003666837.1, NC_015697.1

Genome annotation databases

EnsemblBacteriaiAEI58107; AEI58107; HMPREF0538_21899
GeneIDi5189175
KEGGilru:HMPREF0538_21899

Similar proteinsi

Entry informationi

Entry nameiF8DNX1_LACRS
AccessioniPrimary (citable) accession number: F8DNX1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 28, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health