F8DIG9 (F8DIG9_STREP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenine phosphoribosyltransferase HAMAP-Rule MF_00004
Short name=APRT HAMAP-Rule MF_00004
EC=2.4.2.7 HAMAP-Rule MF_00004

Gene names

Name:	apt HAMAP-Rule MF_00004
Ordered Locus Names:	HMPREF0833_10787 EMBL AEH55818.1

Organism

Streptococcus parasanguinis (strain ATCC 15912 / DSM 6778 / CIP 104372 / LMG 14537) [Complete proteome] [HAMAP]

Taxonomic identifier

760570 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus parasanguis

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP-Rule MF_00004 SAAS SAAS005764
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00004 SAAS SAAS005764
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP-Rule MF_00004 SAAS SAAS005764
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_00004
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00004 SAAS SAAS005764.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family. HAMAP-Rule MF_00004

Ontologies

Keywords
Biological process	Purine salvage HAMAP-Rule MF_00004 SAAS SAAS005764
Cellular component	Cytoplasm HAMAP-Rule MF_00004 SAAS SAAS005764
Molecular function	Glycosyltransferase HAMAP-Rule MF_00004 SAAS SAAS005764 EMBL AEH55818.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	AMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway adenine salvage Inferred from electronic annotation. Source: HAMAP purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F8DIG9 [UniParc]. Last modified September 21, 2011. Version 1. Checksum: 5CAB5CAB556BC7B5	FASTA	170	18,684
	10 20 30 40 50 60 MNLKDYIASI ENYPQEGITF RDISPLMADG NAYSYAIREI VQYATDKKID MIVGPEARGF 70 80 90 100 110 120 IVGCPVAFEL GIGFAPVRKP GKLPREVISA DYEKEYGVDT LCMHADAIKP GQRVLIVDDL 130 140 150 160 170 LATGGTVKAT IEMIEKLGGI VAGCAFLIEL DDLKGREAIG DYDYKVLMHY

References

[1]

"Complete sequence of Streptococcus parasanguinis strain ATCC 15912." Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A., Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X., Perez L., Shen H., Wang Q., Watt J. , Xi L., Xin Y., Zhou J., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A., Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B., Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R. Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15912 / DSM 6778 / CIP 104372 / LMG 14537.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002843 Genomic DNA. Translation: AEH55818.1.
RefSeq	YP_004621746.1. NC_015678.1.
3D structure databases
ProteinModelPortal	F8DIG9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEH55818; AEH55818; HMPREF0833_10787.
GeneID	10835286.
KEGG	scp:HMPREF0833_10787.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00759.
Enzyme and pathway databases
UniPathway	UPA00588; UER00646.
Family and domain databases
HAMAP	MF_00004. Aden_phosphoribosyltr.
InterPro	IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase_dom. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. apt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

F8DIG9_STREP

Accession

Primary (citable) accession number: F8DIG9

Entry history

Integrated into UniProtKB/TrEMBL:	September 21, 2011
Last sequence update:	September 21, 2011
Last modified:	April 3, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)