F8DGC5 (F8DGC5_STREP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase HAMAP-Rule MF_00134
Short name=IGPS HAMAP-Rule MF_00134
EC=4.1.1.48 HAMAP-Rule MF_00134

Gene names

Name:	trpC HAMAP-Rule MF_00134
Ordered Locus Names:	HMPREF0833_11577 EMBL AEH56608.1

Organism

Streptococcus parasanguinis (strain ATCC 15912 / DSM 6778 / CIP 104372 / LMG 14537) [Complete proteome] [HAMAP]

Taxonomic identifier

760570 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus parasanguis

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP-Rule MF_00134 SAAS SAAS013798
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP-Rule MF_00134 SAAS SAAS013798
Sequence similarities	Belongs to the TrpC family. HAMAP-Rule MF_00134

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis HAMAP-Rule MF_00134 SAAS SAAS013798
Molecular function	Decarboxylase HAMAP-Rule MF_00134 SAAS SAAS013798 Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F8DGC5 [UniParc]. Last modified September 21, 2011. Version 1. Checksum: 244F8C3C2EC9325E	FASTA	255	28,630
	10 20 30 40 50 60 MSQEFLPKIL KEKAREVAEM KEEELQPLRE TYRLYDYLKS HPEKLQVIAE VKKASPSLGD 70 80 90 100 110 120 IHVDVDIVAQ AKTYEENGAV MISVLTDEVF FKGSIEYLRE ISSQVRIPTL NKDFIVDEKQ 130 140 150 160 170 180 VIRARNAGAT VILLIVAALS ETRLQELYEF ATHLGLEVLV ETHNLTELEV AHRIGAQIIG 190 200 210 220 230 240 VNNRNLVTFE TDLHTSLELA TNFEQEPVYI SESAIFAAAD ARMLAPYFSG ILVGTALMKA 250 DNVAEKVKEL QIDKG

References

[1]

"Complete sequence of Streptococcus parasanguinis strain ATCC 15912." Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A., Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X., Perez L., Shen H., Wang Q., Watt J. , Xi L., Xin Y., Zhou J., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A., Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B., Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R. Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15912 / DSM 6778 / CIP 104372 / LMG 14537.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002843 Genomic DNA. Translation: AEH56608.1.
RefSeq	YP_004622536.1. NC_015678.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEH56608; AEH56608; HMPREF0833_11577.
GeneID	10836108.
KEGG	scp:HMPREF0833_11577.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K01609.
Enzyme and pathway databases
UniPathway	UPA00035; UER00043.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00134_B. IGPS_B.
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F8DGC5_STREP

Accession

Primary (citable) accession number: F8DGC5

Entry history

Integrated into UniProtKB/TrEMBL:	September 21, 2011
Last sequence update:	September 21, 2011
Last modified:	April 3, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)