ID   F8DG69_STREP            Unreviewed;       595 AA.
AC   F8DG69;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   OrderedLocusNames=HMPREF0833_11517 {ECO:0000313|EMBL:AEH56548.1};
OS   Streptococcus parasanguinis (strain ATCC 15912 / DSM 6778 / CIP 104372 /
OS   LMG 14537).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=760570 {ECO:0000313|EMBL:AEH56548.1, ECO:0000313|Proteomes:UP000001502};
RN   [1] {ECO:0000313|Proteomes:UP000001502}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15912 / DSM 6778 / CIP 104372 / LMG 14537
RC   {ECO:0000313|Proteomes:UP000001502};
RA   Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA   Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA   Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA   Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA   Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA   Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA   Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA   Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA   Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA   Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA   Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA   Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA   Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA   Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA   Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RT   "Complete sequence of Streptococcus parasanguinis strain ATCC 15912.";
RL   Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC         in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|ARBA:ARBA00009809, ECO:0000256|RuleBase:RU003679}.
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DR   EMBL; CP002843; AEH56548.1; -; Genomic_DNA.
DR   RefSeq; WP_013904400.1; NC_015678.1.
DR   AlphaFoldDB; F8DG69; -.
DR   GeneID; 75174381; -.
DR   KEGG; scp:HMPREF0833_11517; -.
DR   HOGENOM; CLU_007853_7_2_9; -.
DR   Proteomes; UP000001502; Chromosome.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR026283; B-gal_1-like.
DR   InterPro; IPR048912; BetaGal1-like_ABD1.
DR   InterPro; IPR048913; BetaGal_gal-bd.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421:SF165; BETA-GALACTOSIDASE; 1.
DR   PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR   Pfam; PF21317; BetaGal_ABD_1; 1.
DR   Pfam; PF21467; BetaGal_gal-bd; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PIRSF; PIRSF006336; B-gal; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU000675};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000675}.
FT   DOMAIN          10..328
FT                   /note="Glycoside hydrolase 35 catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01301"
FT   DOMAIN          373..488
FT                   /note="Beta-galactosidase 1-like first all-beta"
FT                   /evidence="ECO:0000259|Pfam:PF21317"
FT   DOMAIN          506..564
FT                   /note="Beta-galactosidase galactose-binding"
FT                   /evidence="ECO:0000259|Pfam:PF21467"
FT   ACT_SITE        156
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
FT   ACT_SITE        238
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
SQ   SEQUENCE   595 AA;  68663 MW;  750F83D0848EB47D CRC64;
     MDVFEIRDDF YLKGQPFKIL SGAIHYFRID PADWYHSLFN LKALGFNTVE TYVPWNVHEP
     RKGQFDFSGR LDLERFIQTA QSLGLYMIVR PSPFICAEWE FGGLPAWLLE EDMRIRSSDP
     AFIEAVDRYY DHLLGLLTPY QVDQGGPILM MQVENEYGSY GEDKAYLRAI RDLMKKKGVT
     CPLFTSDGPW RAALRAGTLI EEDLFVTGNF GSKAAYNFGQ MQEFFDEYGK KWPLMCMEFW
     DGWFTRWKEP VIQREPEELA EAVHEVLELG SINLYMFHGG TNFGFMNGCS ARGTLDLPQV
     TSYDYGALLN EQGNPTEKYY AIQKMMATYY PEYPQQEPLI KECLPEQTLQ LAAKTSLFGN
     LDNLAQVETS LYPEKMEELG QTTGYLLYET DLELDAEEEK LRIIDGRDRV QIYLDDRHVA
     TQYQTEIGED LFIKGKKKAV TNLKILLENM GRVNYGHKLL ADSQHKGIRT GVCVDLHFHL
     HWKQYPLDLQ DLSQLDFSKE WQAGAPAFYR YDFQLDHTLD TYLDMTGFGK GVVFVNGHNL
     GRFWEVGPTT SLYVPHGFLK EGANSLIVFE TEGRYQETLQ LVQQPTFKEV KGENL
//