Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

F8DFB3 (F8DFB3_STREP) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:HMPREF0833_10157 EMBL AEH55188.1
OrganismStreptococcus parasanguinis (strain ATCC 15912 / DSM 6778 / CIP 104372 / LMG 14537) [Complete proteome] [HAMAP] EMBL AEH55188.1
Taxonomic identifier760570 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain132 – 334203ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding162 – 21756ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2881Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3011Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3011Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3031Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F8DFB3 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 6F48BBD171E540D5

FASTA34838,573
        10         20         30         40         50         60 
MSKQDLILLY GGRSAEREVS VLSAESVMRA IDYQAFSVQT YFITQSGDFI QTQAFEEKPA 

        70         80         90        100        110        120 
DDEKLMTNDT VDWSKKVAPS AIYKEGAVVF PVLHGPMGED GSIQGFLEVL KMPYVGCGIL 

       130        140        150        160        170        180 
ASSVAMDKIT TKRVLESAGI PQVPYVAVVE GDDLEEKIAA IEANLSYPVF TKPSNMGSSV 

       190        200        210        220        230        240 
GISKSENQTE LRTALELAFK YDSRVLVEQG VNAREIEVGL LGNYDVKSTL PGEVVKDVAF 

       250        260        270        280        290        300 
YDYDAKYIDN KITMAIPAQL DPEVVKTMRT NAEKAFRAIG GLGLARCDFF YTDKGEIFLN 

       310        320        330        340 
ELNTMPGFTQ WSMYPLLWDN MGLNYTDLIT KLVELGKEVF QKHEAHLL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002843 Genomic DNA. Translation: AEH55188.1.
RefSeqYP_004621116.1. NC_015678.1.

3D structure databases

ProteinModelPortalF8DFB3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEH55188; AEH55188; HMPREF0833_10157.
GeneID10834650.
KEGGscp:HMPREF0833_10157.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycSPAR760570:GI5E-172-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8DFB3_STREP
AccessionPrimary (citable) accession number: F8DFB3
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 19, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)