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Protein

DNA ligase

Gene

lig

Organism
Halopiger xanaduensis (strain DSM 18323 / JCM 14033 / SH-6)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei253 – 2531ATPUniRule annotation
Active sitei255 – 2551N6-AMP-lysine intermediateUniRule annotation
Binding sitei260 – 2601ATPUniRule annotation
Binding sitei277 – 2771ATPUniRule annotation
Binding sitei306 – 3061ATPUniRule annotation
Binding sitei346 – 3461ATPUniRule annotation
Binding sitei432 – 4321ATPUniRule annotation
Binding sitei438 – 4381ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHXAN797210:GIXL-2062-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Halxa_2706Imported
OrganismiHalopiger xanaduensis (strain DSM 18323 / JCM 14033 / SH-6)Imported
Taxonomic identifieri797210 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalopiger
ProteomesiUP000006794: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiGRPRPFQ.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8D907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFATFADRA AAIEAEPADL EIVAHVTDLL RDAEADLEIV ARFVQGRVFP
60 70 80 90 100
AWDSTTLDIG PSACYEAIAR AAGTNVDADD VEDRLAETGE IGDVAASYDF
110 120 130 140 150
GGQQGLGAFT GGDGGEDDLT VREVYETLCD LAAAEGSGSQ DRKVDLLFGL
160 170 180 190 200
FNRCSSEEAR YLARLVLSEM RIGVGEGAVR DAVAEAFDVP EEEVERALQV
210 220 230 240 250
SNDYGEVARI ARDEGLEGLE AIDLEIGRPV QTMLAQAGTV TDALEEWDEA
260 270 280 290 300
AVEWKYDGAR IQLHHAPDDD TTRVFSRNME EVTDALPEVL EYADETLEEP
310 320 330 340 350
VILDGEVVAV DDDGGPLPFQ EVLKRFRRKH DVEKAREEVT VRPVFFDCLH
360 370 380 390 400
AGGEDLLEEP LTARHDRLRA VLAEDPDAVT ETEDERDVEG LSLLWTTDDP
410 420 430 440 450
DEIEAIDADA LEAGHEGIML KNPESTYSPG RRGKHWRKRK PDVETVDCVV
460 470 480 490 500
TGAEWGEGRR ANFLGTFELS VRDGDDLETV GKVATGITDE KLEELTELLE
510 520 530 540 550
PHIAAEDGQD VDLEPAVVFE VGYEEIQTSP TYSSGYALRF PRFLAVRSDK
560
EPEDADTLER VEALRS
Length:566
Mass (Da):62,193
Last modified:September 21, 2011 - v1
Checksum:i16B23246232B88E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002839 Genomic DNA. Translation: AEH37323.1.
RefSeqiWP_013880213.1. NC_015666.1.
YP_004597202.1. NC_015666.1.

Genome annotation databases

EnsemblBacteriaiAEH37323; AEH37323; Halxa_2706.
GeneIDi10797660.
KEGGihxa:Halxa_2706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002839 Genomic DNA. Translation: AEH37323.1.
RefSeqiWP_013880213.1. NC_015666.1.
YP_004597202.1. NC_015666.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEH37323; AEH37323; Halxa_2706.
GeneIDi10797660.
KEGGihxa:Halxa_2706.

Phylogenomic databases

KOiK10747.
OMAiGRPRPFQ.

Enzyme and pathway databases

BioCyciHXAN797210:GIXL-2062-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18323 / JCM 14033 / SH-6Imported.

Entry informationi

Entry nameiF8D907_HALXS
AccessioniPrimary (citable) accession number: F8D907
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 4, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.