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F8D907

- F8D907_HALXS

UniProt

F8D907 - F8D907_HALXS

Protein

DNA ligase

Gene

lig

Organism
Halopiger xanaduensis (strain DSM 18323 / JCM 14033 / SH-6)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei253 – 2531ATPUniRule annotation
    Active sitei255 – 2551N6-AMP-lysine intermediateUniRule annotation
    Binding sitei260 – 2601ATPUniRule annotation
    Binding sitei277 – 2771ATPUniRule annotation
    Binding sitei306 – 3061ATPUniRule annotation
    Binding sitei346 – 3461ATPUniRule annotation
    Binding sitei432 – 4321ATPUniRule annotation
    Binding sitei438 – 4381ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHXAN797210:GIXL-2062-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Halxa_2706Imported
    OrganismiHalopiger xanaduensis (strain DSM 18323 / JCM 14033 / SH-6)Imported
    Taxonomic identifieri797210 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalopiger
    ProteomesiUP000006794: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8D907-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQFATFADRA AAIEAEPADL EIVAHVTDLL RDAEADLEIV ARFVQGRVFP    50
    AWDSTTLDIG PSACYEAIAR AAGTNVDADD VEDRLAETGE IGDVAASYDF 100
    GGQQGLGAFT GGDGGEDDLT VREVYETLCD LAAAEGSGSQ DRKVDLLFGL 150
    FNRCSSEEAR YLARLVLSEM RIGVGEGAVR DAVAEAFDVP EEEVERALQV 200
    SNDYGEVARI ARDEGLEGLE AIDLEIGRPV QTMLAQAGTV TDALEEWDEA 250
    AVEWKYDGAR IQLHHAPDDD TTRVFSRNME EVTDALPEVL EYADETLEEP 300
    VILDGEVVAV DDDGGPLPFQ EVLKRFRRKH DVEKAREEVT VRPVFFDCLH 350
    AGGEDLLEEP LTARHDRLRA VLAEDPDAVT ETEDERDVEG LSLLWTTDDP 400
    DEIEAIDADA LEAGHEGIML KNPESTYSPG RRGKHWRKRK PDVETVDCVV 450
    TGAEWGEGRR ANFLGTFELS VRDGDDLETV GKVATGITDE KLEELTELLE 500
    PHIAAEDGQD VDLEPAVVFE VGYEEIQTSP TYSSGYALRF PRFLAVRSDK 550
    EPEDADTLER VEALRS 566
    Length:566
    Mass (Da):62,193
    Last modified:September 21, 2011 - v1
    Checksum:i16B23246232B88E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002839 Genomic DNA. Translation: AEH37323.1.
    RefSeqiWP_013880213.1. NC_015666.1.
    YP_004597202.1. NC_015666.1.

    Genome annotation databases

    EnsemblBacteriaiAEH37323; AEH37323; Halxa_2706.
    GeneIDi10797660.
    KEGGihxa:Halxa_2706.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002839 Genomic DNA. Translation: AEH37323.1 .
    RefSeqi WP_013880213.1. NC_015666.1.
    YP_004597202.1. NC_015666.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEH37323 ; AEH37323 ; Halxa_2706 .
    GeneIDi 10797660.
    KEGGi hxa:Halxa_2706.

    Phylogenomic databases

    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci HXAN797210:GIXL-2062-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 18323 / JCM 14033 / SH-6Imported.

    Entry informationi

    Entry nameiF8D907_HALXS
    AccessioniPrimary (citable) accession number: F8D907
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3