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F8D907

- F8D907_HALXS

UniProt

F8D907 - F8D907_HALXS

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Protein
DNA ligase
Gene
lig, Halxa_2706
Organism
Halopiger xanaduensis (strain DSM 18323 / JCM 14033 / SH-6)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei253 – 2531ATP By similarityUniRule annotation
Active sitei255 – 2551N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei260 – 2601ATP By similarityUniRule annotation
Binding sitei277 – 2771ATP By similarityUniRule annotation
Binding sitei306 – 3061ATP By similarityUniRule annotation
Binding sitei346 – 3461ATP By similarityUniRule annotation
Binding sitei432 – 4321ATP By similarityUniRule annotation
Binding sitei438 – 4381ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHXAN797210:GIXL-2062-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Halxa_2706Imported
OrganismiHalopiger xanaduensis (strain DSM 18323 / JCM 14033 / SH-6)Imported
Taxonomic identifieri797210 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalopiger
ProteomesiUP000006794: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8D907-1 [UniParc]FASTAAdd to Basket

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MQFATFADRA AAIEAEPADL EIVAHVTDLL RDAEADLEIV ARFVQGRVFP    50
AWDSTTLDIG PSACYEAIAR AAGTNVDADD VEDRLAETGE IGDVAASYDF 100
GGQQGLGAFT GGDGGEDDLT VREVYETLCD LAAAEGSGSQ DRKVDLLFGL 150
FNRCSSEEAR YLARLVLSEM RIGVGEGAVR DAVAEAFDVP EEEVERALQV 200
SNDYGEVARI ARDEGLEGLE AIDLEIGRPV QTMLAQAGTV TDALEEWDEA 250
AVEWKYDGAR IQLHHAPDDD TTRVFSRNME EVTDALPEVL EYADETLEEP 300
VILDGEVVAV DDDGGPLPFQ EVLKRFRRKH DVEKAREEVT VRPVFFDCLH 350
AGGEDLLEEP LTARHDRLRA VLAEDPDAVT ETEDERDVEG LSLLWTTDDP 400
DEIEAIDADA LEAGHEGIML KNPESTYSPG RRGKHWRKRK PDVETVDCVV 450
TGAEWGEGRR ANFLGTFELS VRDGDDLETV GKVATGITDE KLEELTELLE 500
PHIAAEDGQD VDLEPAVVFE VGYEEIQTSP TYSSGYALRF PRFLAVRSDK 550
EPEDADTLER VEALRS 566
Length:566
Mass (Da):62,193
Last modified:September 21, 2011 - v1
Checksum:i16B23246232B88E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002839 Genomic DNA. Translation: AEH37323.1.
RefSeqiWP_013880213.1. NC_015666.1.
YP_004597202.1. NC_015666.1.

Genome annotation databases

EnsemblBacteriaiAEH37323; AEH37323; Halxa_2706.
GeneIDi10797660.
KEGGihxa:Halxa_2706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002839 Genomic DNA. Translation: AEH37323.1 .
RefSeqi WP_013880213.1. NC_015666.1.
YP_004597202.1. NC_015666.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEH37323 ; AEH37323 ; Halxa_2706 .
GeneIDi 10797660.
KEGGi hxa:Halxa_2706.

Phylogenomic databases

KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci HXAN797210:GIXL-2062-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18323 / JCM 14033 / SH-6.

Entry informationi

Entry nameiF8D907_HALXS
AccessioniPrimary (citable) accession number: F8D907
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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