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Protein

DNA ligase

Gene

lig

Organism
Halopiger xanaduensis (strain DSM 18323 / JCM 14033 / SH-6)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei253ATPUniRule annotation1
Active sitei255N6-AMP-lysine intermediateUniRule annotation1
Binding sitei260ATPUniRule annotation1
Binding sitei277ATPUniRule annotation1
Binding sitei306ATPUniRule annotation1
Binding sitei346ATPUniRule annotation1
Binding sitei432ATPUniRule annotation1
Binding sitei438ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Halxa_2706Imported
OrganismiHalopiger xanaduensis (strain DSM 18323 / JCM 14033 / SH-6)Imported
Taxonomic identifieri797210 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaNatrialbalesNatrialbaceaeHalopiger
Proteomesi
  • UP000006794 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi797210.Halxa_2706

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini334 – 473DNA_LIGASE_A3InterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.101 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

F8D907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFATFADRA AAIEAEPADL EIVAHVTDLL RDAEADLEIV ARFVQGRVFP
60 70 80 90 100
AWDSTTLDIG PSACYEAIAR AAGTNVDADD VEDRLAETGE IGDVAASYDF
110 120 130 140 150
GGQQGLGAFT GGDGGEDDLT VREVYETLCD LAAAEGSGSQ DRKVDLLFGL
160 170 180 190 200
FNRCSSEEAR YLARLVLSEM RIGVGEGAVR DAVAEAFDVP EEEVERALQV
210 220 230 240 250
SNDYGEVARI ARDEGLEGLE AIDLEIGRPV QTMLAQAGTV TDALEEWDEA
260 270 280 290 300
AVEWKYDGAR IQLHHAPDDD TTRVFSRNME EVTDALPEVL EYADETLEEP
310 320 330 340 350
VILDGEVVAV DDDGGPLPFQ EVLKRFRRKH DVEKAREEVT VRPVFFDCLH
360 370 380 390 400
AGGEDLLEEP LTARHDRLRA VLAEDPDAVT ETEDERDVEG LSLLWTTDDP
410 420 430 440 450
DEIEAIDADA LEAGHEGIML KNPESTYSPG RRGKHWRKRK PDVETVDCVV
460 470 480 490 500
TGAEWGEGRR ANFLGTFELS VRDGDDLETV GKVATGITDE KLEELTELLE
510 520 530 540 550
PHIAAEDGQD VDLEPAVVFE VGYEEIQTSP TYSSGYALRF PRFLAVRSDK
560
EPEDADTLER VEALRS
Length:566
Mass (Da):62,193
Last modified:September 21, 2011 - v1
Checksum:i16B23246232B88E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002839 Genomic DNA Translation: AEH37323.1
RefSeqiWP_013880213.1, NC_015666.1

Genome annotation databases

EnsemblBacteriaiAEH37323; AEH37323; Halxa_2706
GeneIDi10797660
KEGGihxa:Halxa_2706

Similar proteinsi

Entry informationi

Entry nameiF8D907_HALXS
AccessioniPrimary (citable) accession number: F8D907
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported