F8CZN6 (F8CZN6_GEOTC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Regulatory protein spx HAMAP-Rule MF_01132

Gene names

Name:	spxA HAMAP-Rule MF_01132
Ordered Locus Names:	Geoth_3048 EMBL AEH48923.1

Organism

Geobacillus thermoglucosidasius (strain C56-YS93) [Complete proteome] [HAMAP] EMBL AEH48923.1

Taxonomic identifier

634956 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Geobacillus › Bacillus thermoglucosidasius

Protein attributes

Sequence length	132 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress By similarity. HAMAP-Rule MF_01132
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01132.
Sequence similarities	Belongs to the ArsC family. Spx subfamily. HAMAP-Rule MF_01132

Ontologies

Keywords
Biological process	Transcription Transcription regulation HAMAP-Rule MF_01132
Cellular component	Cytoplasm HAMAP-Rule MF_01132
Domain	Redox-active center HAMAP-Rule MF_01132
PTM	Disulfide bond HAMAP-Rule MF_01132
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Disulfide bond	10 ↔ 13		Redox-active By similarity HAMAP-Rule MF_01132

Sequences

	Sequence		Length	Mass (Da)
	F8CZN6 [UniParc]. Last modified September 21, 2011. Version 1. Checksum: BB442E235362AA23	FASTA	132	15,695
	10 20 30 40 50 60 MVKLYTSPSC TSCRKAKAWL EKHNIPYVER NIFSEPLTIE EIKEILRMTE TGTDEIISTR 70 80 90 100 110 120 SKVFQKLNIN LESLPLQDLY ELIQKHPGIL RRPIIIDEKR LQVGYNEDEI RRFLPRKVRA 130 YQLRQAQRLV NE

References

[1]

"Complete sequence of chromosome of Geobacillus thermoglucosidasius C56-YS93." Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P. , Kourtz L., Mead D., Woyke T. Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C56-YS93.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002835 Genomic DNA. Translation: AEH48923.1.
RefSeq	YP_004589004.1. NC_015660.1.
3D structure databases
ProteinModelPortal	F8CZN6.
SMR	F8CZN6. Positions 1-118.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEH48923; AEH48923; Geoth_3048.
GeneID	10789214.
KEGG	gth:Geoth_3048.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K16509.
Enzyme and pathway databases
BioCyc	GTHE634956:GHH3-3193-MONOMER.
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
HAMAP	MF_01132. SpxA.
InterPro	IPR006660. Arsenate_reductase-like. IPR012336. Thioredoxin-like_fold. IPR023731. Tscrpt_reg_Spx. IPR006504. Tscrpt_reg_Spx/MgsR. [Graphical view]
Pfam	PF03960. ArsC. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR01617. arsC_related. 1 hit.
PROSITE	PS51353. ARSC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F8CZN6_GEOTC

Accession

Primary (citable) accession number: F8CZN6

Entry history

Integrated into UniProtKB/TrEMBL:	September 21, 2011
Last sequence update:	September 21, 2011
Last modified:	April 3, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)