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F8CX34

- F8CX34_GEOTC

UniProt

F8CX34 - F8CX34_GEOTC

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Protein
Isocitrate dehydrogenase [NADP]
Gene
Geoth_0903
Organism
Geobacillus thermoglucosidasius (strain C56-YS93)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciGTHE634956:GHH3-938-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Geoth_0903Imported
OrganismiGeobacillus thermoglucosidasius (strain C56-YS93)Imported
Taxonomic identifieri634956 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000007149: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8CX34-1 [UniParc]FASTAAdd to Basket

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MVTQGEKITV TNGVLNVPNN PIIPFIEGDG TGPDIWAAAS RVLEAAVEKA    50
YKGEKKIVWK EVLAGEKAYK QTGEWLPQET LDVIREYIIA IKGPLTTPVG 100
GGIRSLNVAL RQELDLFVCL RPVRYFKGVP SPVKRPEDTD MVIFRENTED 150
IYAGIEYAKG TPEVKKVIDF LQNEMGVRKI RFPETSGIGI KPISEQGTKR 200
LVRAAIKYAI DHGRKSVTLV HKGNIMKFTE GAFKNWGYEL AEEEFSDKVF 250
TWAQYDRIVE TEGKEAANKA LAEAEEAGKI IIKDVIADIF LQQILTRPRE 300
FDVVATMNLN GDYISDALAA QVGGIGIAPG ANINYETGHA IFEATHGTAP 350
KYAGLDKVNP SSVILSGVMM FEHLGWNEAA KLIVDALEKT IASKIVTYDF 400
ARLMEGATEV KCSEFADAII RNME 424
Length:424
Mass (Da):46,770
Last modified:September 21, 2011 - v1
Checksum:i9A52A0F15EBF5BDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002835 Genomic DNA. Translation: AEH46901.1.
RefSeqiYP_004586982.1. NC_015660.1.

Genome annotation databases

EnsemblBacteriaiAEH46901; AEH46901; Geoth_0903.
GeneIDi10787055.
KEGGigth:Geoth_0903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002835 Genomic DNA. Translation: AEH46901.1 .
RefSeqi YP_004586982.1. NC_015660.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEH46901 ; AEH46901 ; Geoth_0903 .
GeneIDi 10787055.
KEGGi gth:Geoth_0903.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci GTHE634956:GHH3-938-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Geobacillus thermoglucosidasius C56-YS93."
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P.
    , Kourtz L., Mead D., Woyke T.
    Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C56-YS93.

Entry informationi

Entry nameiF8CX34_GEOTC
AccessioniPrimary (citable) accession number: F8CX34
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: October 16, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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