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Protein

Isocitrate dehydrogenase [NADP]

Gene

Geoth_0903

Organism
Geobacillus thermoglucosidasius (strain C56-YS93)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciGTHE634956:GHH3-938-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Geoth_0903Imported
OrganismiGeobacillus thermoglucosidasius (strain C56-YS93)Imported
Taxonomic identifieri634956 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000007149: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8CX34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTQGEKITV TNGVLNVPNN PIIPFIEGDG TGPDIWAAAS RVLEAAVEKA
60 70 80 90 100
YKGEKKIVWK EVLAGEKAYK QTGEWLPQET LDVIREYIIA IKGPLTTPVG
110 120 130 140 150
GGIRSLNVAL RQELDLFVCL RPVRYFKGVP SPVKRPEDTD MVIFRENTED
160 170 180 190 200
IYAGIEYAKG TPEVKKVIDF LQNEMGVRKI RFPETSGIGI KPISEQGTKR
210 220 230 240 250
LVRAAIKYAI DHGRKSVTLV HKGNIMKFTE GAFKNWGYEL AEEEFSDKVF
260 270 280 290 300
TWAQYDRIVE TEGKEAANKA LAEAEEAGKI IIKDVIADIF LQQILTRPRE
310 320 330 340 350
FDVVATMNLN GDYISDALAA QVGGIGIAPG ANINYETGHA IFEATHGTAP
360 370 380 390 400
KYAGLDKVNP SSVILSGVMM FEHLGWNEAA KLIVDALEKT IASKIVTYDF
410 420
ARLMEGATEV KCSEFADAII RNME
Length:424
Mass (Da):46,770
Last modified:September 21, 2011 - v1
Checksum:i9A52A0F15EBF5BDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002835 Genomic DNA. Translation: AEH46901.1.
RefSeqiYP_004586982.1. NC_015660.1.

Genome annotation databases

EnsemblBacteriaiAEH46901; AEH46901; Geoth_0903.
GeneIDi10787055.
KEGGigth:Geoth_0903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002835 Genomic DNA. Translation: AEH46901.1.
RefSeqiYP_004586982.1. NC_015660.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEH46901; AEH46901; Geoth_0903.
GeneIDi10787055.
KEGGigth:Geoth_0903.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciGTHE634956:GHH3-938-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Geobacillus thermoglucosidasius C56-YS93."
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P.
    , Kourtz L., Mead D., Woyke T.
    Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C56-YS93Imported.

Entry informationi

Entry nameiF8CX34_GEOTC
AccessioniPrimary (citable) accession number: F8CX34
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 4, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.