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F8CU85

- F8CU85_GEOTC

UniProt

F8CU85 - F8CU85_GEOTC

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Protein

Alanine racemase

Gene

Geoth_3701

Organism
Geobacillus thermoglucosidasius (strain C56-YS93)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Active sitei263 – 2631Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGTHE634956:GHH3-3793-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Geoth_3701Imported
OrganismiGeobacillus thermoglucosidasius (strain C56-YS93)Imported
Taxonomic identifieri634956 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000007149: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF8CU85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8CU85-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFYRDTWAEI DLDAIYYNVS QLKNFLPNDV RIMAVVKANA YGHGDVQVAK
60 70 80 90 100
TALEAGASYL AVAFLDEALA LRKGGIDAPI LVLGASRPSD INIAAKHRIT
110 120 130 140 150
LTVFQAEWIE QAADFYSETA PVLFHLKMDT GMGRLGVKEE TETKRLIEQI
160 170 180 190 200
DRHPYFSLEG VYTHFATADE INTGYFSFQY DNFLRMLEWL PYKPPLIHCG
210 220 230 240 250
NSATTLRFPD KVFNMVRFGI SMYGLSPSPE IKQYLPYTLK EAFSLHSRLV
260 270 280 290 300
HVKKLKPGEK VSYGATYTAE TEQWVGTVPI GYADGWLRKL QNFHVLVNGE
310 320 330 340 350
KAPIIGRICM DQLMVRLPKQ LPVGTKVTLI GRQGDKYISV DDVAQYLDTI
360 370 380
NYEIPCTISY RVPRIFFRNK SIMEVRNLVY A
Length:381
Mass (Da):43,277
Last modified:September 21, 2011 - v1
Checksum:i31A6DD05C4F17E4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002835 Genomic DNA. Translation: AEH49527.1.
RefSeqiYP_004589608.1. NC_015660.1.

Genome annotation databases

EnsemblBacteriaiAEH49527; AEH49527; Geoth_3701.
GeneIDi10789911.
KEGGigth:Geoth_3701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002835 Genomic DNA. Translation: AEH49527.1 .
RefSeqi YP_004589608.1. NC_015660.1.

3D structure databases

ProteinModelPortali F8CU85.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEH49527 ; AEH49527 ; Geoth_3701 .
GeneIDi 10789911.
KEGGi gth:Geoth_3701.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci GTHE634956:GHH3-3793-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Geobacillus thermoglucosidasius C56-YS93."
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P.
    , Kourtz L., Mead D., Woyke T.
    Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C56-YS93Imported.

Entry informationi

Entry nameiF8CU85_GEOTC
AccessioniPrimary (citable) accession number: F8CU85
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 26, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3