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F8CU85

- F8CU85_GEOTC

UniProt

F8CU85 - F8CU85_GEOTC

Protein

Alanine racemase

Gene

Geoth_3701

Organism
Geobacillus thermoglucosidasius (strain C56-YS93)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei134 – 1341SubstrateUniRule annotation
    Active sitei263 – 2631Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei310 – 3101Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciGTHE634956:GHH3-3793-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Geoth_3701Imported
    OrganismiGeobacillus thermoglucosidasius (strain C56-YS93)Imported
    Taxonomic identifieri634956 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    ProteomesiUP000007149: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF8CU85.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8CU85-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFYRDTWAEI DLDAIYYNVS QLKNFLPNDV RIMAVVKANA YGHGDVQVAK    50
    TALEAGASYL AVAFLDEALA LRKGGIDAPI LVLGASRPSD INIAAKHRIT 100
    LTVFQAEWIE QAADFYSETA PVLFHLKMDT GMGRLGVKEE TETKRLIEQI 150
    DRHPYFSLEG VYTHFATADE INTGYFSFQY DNFLRMLEWL PYKPPLIHCG 200
    NSATTLRFPD KVFNMVRFGI SMYGLSPSPE IKQYLPYTLK EAFSLHSRLV 250
    HVKKLKPGEK VSYGATYTAE TEQWVGTVPI GYADGWLRKL QNFHVLVNGE 300
    KAPIIGRICM DQLMVRLPKQ LPVGTKVTLI GRQGDKYISV DDVAQYLDTI 350
    NYEIPCTISY RVPRIFFRNK SIMEVRNLVY A 381
    Length:381
    Mass (Da):43,277
    Last modified:September 21, 2011 - v1
    Checksum:i31A6DD05C4F17E4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002835 Genomic DNA. Translation: AEH49527.1.
    RefSeqiWP_013877617.1. NC_015660.1.
    YP_004589608.1. NC_015660.1.

    Genome annotation databases

    EnsemblBacteriaiAEH49527; AEH49527; Geoth_3701.
    GeneIDi10789911.
    KEGGigth:Geoth_3701.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002835 Genomic DNA. Translation: AEH49527.1 .
    RefSeqi WP_013877617.1. NC_015660.1.
    YP_004589608.1. NC_015660.1.

    3D structure databases

    ProteinModelPortali F8CU85.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEH49527 ; AEH49527 ; Geoth_3701 .
    GeneIDi 10789911.
    KEGGi gth:Geoth_3701.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci GTHE634956:GHH3-3793-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Geobacillus thermoglucosidasius C56-YS93."
      Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P.
      , Kourtz L., Mead D., Woyke T.
      Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C56-YS93Imported.

    Entry informationi

    Entry nameiF8CU85_GEOTC
    AccessioniPrimary (citable) accession number: F8CU85
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3