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F8CU85

- F8CU85_GEOTC

UniProt

F8CU85 - F8CU85_GEOTC

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Protein
Alanine racemase
Gene
Geoth_3701
Organism
Geobacillus thermoglucosidasius (strain C56-YS93)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei134 – 1341Substrate By similarityUniRule annotation
Active sitei263 – 2631Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciGTHE634956:GHH3-3793-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Geoth_3701Imported
OrganismiGeobacillus thermoglucosidasius (strain C56-YS93)Imported
Taxonomic identifieri634956 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000007149: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF8CU85.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8CU85-1 [UniParc]FASTAAdd to Basket

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MFYRDTWAEI DLDAIYYNVS QLKNFLPNDV RIMAVVKANA YGHGDVQVAK    50
TALEAGASYL AVAFLDEALA LRKGGIDAPI LVLGASRPSD INIAAKHRIT 100
LTVFQAEWIE QAADFYSETA PVLFHLKMDT GMGRLGVKEE TETKRLIEQI 150
DRHPYFSLEG VYTHFATADE INTGYFSFQY DNFLRMLEWL PYKPPLIHCG 200
NSATTLRFPD KVFNMVRFGI SMYGLSPSPE IKQYLPYTLK EAFSLHSRLV 250
HVKKLKPGEK VSYGATYTAE TEQWVGTVPI GYADGWLRKL QNFHVLVNGE 300
KAPIIGRICM DQLMVRLPKQ LPVGTKVTLI GRQGDKYISV DDVAQYLDTI 350
NYEIPCTISY RVPRIFFRNK SIMEVRNLVY A 381
Length:381
Mass (Da):43,277
Last modified:September 21, 2011 - v1
Checksum:i31A6DD05C4F17E4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002835 Genomic DNA. Translation: AEH49527.1.
RefSeqiWP_013877617.1. NC_015660.1.
YP_004589608.1. NC_015660.1.

Genome annotation databases

EnsemblBacteriaiAEH49527; AEH49527; Geoth_3701.
GeneIDi10789911.
KEGGigth:Geoth_3701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002835 Genomic DNA. Translation: AEH49527.1 .
RefSeqi WP_013877617.1. NC_015660.1.
YP_004589608.1. NC_015660.1.

3D structure databases

ProteinModelPortali F8CU85.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEH49527 ; AEH49527 ; Geoth_3701 .
GeneIDi 10789911.
KEGGi gth:Geoth_3701.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci GTHE634956:GHH3-3793-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Geobacillus thermoglucosidasius C56-YS93."
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P.
    , Kourtz L., Mead D., Woyke T.
    Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C56-YS93.

Entry informationi

Entry nameiF8CU85_GEOTC
AccessioniPrimary (citable) accession number: F8CU85
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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