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Protein
Submitted name:

(P)ppGpp synthetase I, SpoT/RelA

Gene

Geoth_1060

Organism
Geobacillus thermoglucosidasius (strain C56-YS93)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.UniRule annotation

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. GTP diphosphokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine tetraphosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Enzyme and pathway databases

BioCyciGTHE634956:GHH3-1096-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
(P)ppGpp synthetase I, SpoT/RelAImported (EC:2.7.6.5Imported)
Gene namesi
Ordered Locus Names:Geoth_1060Imported
OrganismiGeobacillus thermoglucosidasius (strain C56-YS93)Imported
Taxonomic identifieri634956 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000007149: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF8CSV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the relA/spoT family.UniRule annotation
Contains HD domain.SAAS annotation

Phylogenomic databases

KOiK00951.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8CSV5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANEQVLTAE QVFEQASYYL PEKDVEFIKK AYEFADRAHR DQYRKSGEPY
60 70 80 90 100
IIHPIQVAGI LVDLKMDPAT IAAGFLHDVV EDTEATKEDL EREFGSEVAM
110 120 130 140 150
LVDGVTKLGK IKYKSQEEQQ AENHRKMFLA MAQDIRVILI KLADRLHNMR
160 170 180 190 200
TLKHLPIEKQ RRIANETLEI FAPLAHRLGI SKIKWELEDT ALRYLNPQQY
210 220 230 240 250
YRIVNLMKKK RAEREQYLEE VIQEVRERLN EVSIPCEIYG RPKHIYSIYR
260 270 280 290 300
KMVMQNKQFN EIYDLLAVRI IVNSIKDCYA VLGIIHTCWK PMPGRFKDYI
310 320 330 340 350
AMPKPNMYQS LHTTVIGPKG EPLEVQIRTF EMHQIAEFGI AAHWAYKEGK
360 370 380 390 400
TIKPNSFEEK LSWFREILEW QNDASNAEEF MESLKMDLFS DMVFVFTPKG
410 420 430 440 450
DVIELPAGSV PIDFAYRIHS EIGNKTIGAK VNGKMVPLDY KLQTGDIVEI
460 470 480 490 500
LTSKHSYGPS QDWLKLAQTS HAKNKIRQFF KKQRREENIE KGRELVEKEV
510 520 530 540 550
RSLGFDVKEI LTAENVKRVA EKFNFSNEED MYAAVGFHGI TAAQIAHRLT
560 570 580 590 600
DKWRKQRDLE EQQKKLTETM SETKVPVAKK RDCGIRVQGM DNLLIRLSRC
610 620 630 640 650
CNPVPGDEII GFITRGRGIS VHRIDCPNVQ SEEAADRLIS VEWESDKSNR
660 670 680 690 700
EYNVEIEITG YDRRGLLNEV LQAVNETKTD ISAVSGRSDH RNKIATIHMT
710 720 730
IAIRNISHLQ KIVDRIKQIS DIYSVQRIMN N
Length:731
Mass (Da):84,702
Last modified:September 21, 2011 - v1
Checksum:i2FCC2AF5C7C7C8EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002835 Genomic DNA. Translation: AEH47057.1.
RefSeqiYP_004587138.1. NC_015660.1.

Genome annotation databases

EnsemblBacteriaiAEH47057; AEH47057; Geoth_1060.
GeneIDi10787213.
KEGGigth:Geoth_1060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002835 Genomic DNA. Translation: AEH47057.1.
RefSeqiYP_004587138.1. NC_015660.1.

3D structure databases

ProteinModelPortaliF8CSV5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEH47057; AEH47057; Geoth_1060.
GeneIDi10787213.
KEGGigth:Geoth_1060.

Phylogenomic databases

KOiK00951.

Enzyme and pathway databases

BioCyciGTHE634956:GHH3-1096-MONOMER.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Geobacillus thermoglucosidasius C56-YS93."
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P.
    , Kourtz L., Mead D., Woyke T.
    Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C56-YS93Imported.

Entry informationi

Entry nameiF8CSV5_GEOTC
AccessioniPrimary (citable) accession number: F8CSV5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: January 7, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.