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F8CLT9 (F8CLT9_MYXFH) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:LILAB_35470 EMBL AEI68975.1
OrganismMyxococcus fulvus (strain ATCC BAA-855 / HW-1) [Complete proteome] [HAMAP] EMBL AEI68975.1
Taxonomic identifier483219 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain114 – 312199ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding142 – 19756ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2661Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2791Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2791Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2811Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F8CLT9 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 9B6CAD595EC0934D

FASTA31833,598
        10         20         30         40         50         60 
MTPNRGAFTK DELKQKRVGV LLGGLSAERD VSLRTGEAVS GALRGLGYDV VDIDVGRDLP 

        70         80         90        100        110        120 
ARLAAEKVDV AWLAVHGRYG EDGCLQGLLE SLFIPYTGSG VLASALGMDK VYAKQVFVAH 

       130        140        150        160        170        180 
GIPTPAYRSF RDAASALAAA DSLSFPFPVV VKPSREGSSV GVHICKTRDA YEAAVQDAAK 

       190        200        210        220        230        240 
YAGTLLVEQF VKGREVQGGV LDDEALGVIE VRAAREFYDY DAKYKAGTGT QYLFPAPLPP 

       250        260        270        280        290        300 
DQYARVNEVC LAAHQALGCS GGSRSDVIVT DGGEVFLLET NTLPGMTATS LLPKIAAGRG 

       310 
IDFPALCERL LLGACLKA 

« Hide

References

[1]"Genome Sequence of the Halotolerant Marine Bacterium Myxococcus fulvus HW-1."
Li Z.F., Li X., Liu H., Liu X., Han K., Wu Z.H., Hu W., Li F.F., Li Y.Z.
J. Bacteriol. 193:5015-5016(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-855 / HW-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002830 Genomic DNA. Translation: AEI68975.1.
RefSeqYP_004670053.1. NC_015711.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEI68975; AEI68975; LILAB_35470.
GeneID10881580.
KEGGmfu:LILAB_35470.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAANDTQYR.

Enzyme and pathway databases

BioCycMFUL483219:GJEO-7117-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8CLT9_MYXFH
AccessionPrimary (citable) accession number: F8CLT9
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 11, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)