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F8CDQ4

- F8CDQ4_MYXFH

UniProt

F8CDQ4 - F8CDQ4_MYXFH

Protein

Thymidine kinase

Gene

tdk

Organism
Myxococcus fulvus (strain ATCC BAA-855 / HW-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731Proton acceptorUniRule annotation
    Metal bindingi129 – 1291ZincUniRule annotation
    Metal bindingi132 – 1321ZincUniRule annotation
    Metal bindingi161 – 1611ZincUniRule annotation
    Metal bindingi164 – 1641ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi72 – 754ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

    Enzyme and pathway databases

    BioCyciMFUL483219:GJEO-6678-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:LILAB_33315Imported
    OrganismiMyxococcus fulvus (strain ATCC BAA-855 / HW-1)Imported
    Taxonomic identifieri483219 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
    ProteomesiUP000000488: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.
    OMAiDHISEST.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F8CDQ4-1 [UniParc]FASTAAdd to Basket

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    MFSGKTEELI RRVQRAVYGK QKVQVFKPRL DNRYDESAVV SHSQLKVMST    50
    AIERAEEIFY RLAPDTQVVG IDEVQFFGSE VVAVVEALAN KGLRVICAGL 100
    DQDYQGRPFE PMPQLMAVSE YVTKELAICV VCGNPANRSQ RIVSSGERVV 150
    VGAAGAYEPR CRKCHVAEPA EGTPPQTLEL FD 182
    Length:182
    Mass (Da):20,178
    Last modified:September 21, 2011 - v1
    Checksum:i0D5185991CF0DAD9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002830 Genomic DNA. Translation: AEI68544.1.
    RefSeqiWP_013941627.1. NC_015711.1.
    YP_004669622.1. NC_015711.1.

    Genome annotation databases

    EnsemblBacteriaiAEI68544; AEI68544; LILAB_33315.
    GeneIDi10881141.
    KEGGimfu:LILAB_33315.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002830 Genomic DNA. Translation: AEI68544.1 .
    RefSeqi WP_013941627.1. NC_015711.1.
    YP_004669622.1. NC_015711.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEI68544 ; AEI68544 ; LILAB_33315 .
    GeneIDi 10881141.
    KEGGi mfu:LILAB_33315.

    Phylogenomic databases

    KOi K00857.
    OMAi DHISEST.

    Enzyme and pathway databases

    BioCyci MFUL483219:GJEO-6678-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the halotolerant marine bacterium Myxococcus fulvus HW-1."
      Li Z.F., Li X., Liu H., Liu X., Han K., Wu Z.H., Hu W., Li F.F., Li Y.Z.
      J. Bacteriol. 193:5015-5016(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-855 / HW-1Imported.

    Entry informationi

    Entry nameiF8CDQ4_MYXFH
    AccessioniPrimary (citable) accession number: F8CDQ4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3