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F8BKC8

- F8BKC8_OLICM

UniProt

F8BKC8 - F8BKC8_OLICM

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Oligotropha carboxidovorans (strain OM4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei210 – 2101Critical for catalysisUniRule annotation
Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
Binding sitei258 – 2581NADPUniRule annotation
Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi308 – 3136NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciOCAR1031710:GLI1-2543-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:OCA4_c25430Imported
OrganismiOligotropha carboxidovorans (strain OM4)Imported
Taxonomic identifieri1031710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeOligotropha
ProteomesiUP000000487: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF8BKC8.
SMRiF8BKC8. Positions 3-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8BKC8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIKVANPV VELDGDEMTR IIWQYIKDKL IHPFLDVNLE YYDLGMEHRD
60 70 80 90 100
KTNDQVTIDA ANAIKKHGVG VKCATITPDE ARVKEFNLKE MWKSPNGTIR
110 120 130 140 150
NILGGVIFRE PIICKNVPRL VPGWNKPIII GRHAFGDQYR ATDFKFPGKG
160 170 180 190 200
TLTMKFVGED GSVIEKEVFK SPGAGVAMGM YNLDDSIKDF ARASFNYGLS
210 220 230 240 250
RGYPVYLSTK NTILKVYDGR FKDIFQEIYG AEFKKEFEAK GLTYEHRLID
260 270 280 290 300
DMVASALKWS GGYVWACKNY DGDVQSDTVA QGYGSLGLMT SVLLTPDGKT
310 320 330 340 350
VEAEAAHGTV TRHYREHQKG KETSTNSIAS IFAWTQGLAH RAKLDNNEAL
360 370 380 390 400
AKFAKTLERV CVETVESGSM TKDLALLVGP DQKWLSTTGF LDKVAENLTK

AMATA
Length:405
Mass (Da):45,091
Last modified:September 21, 2011 - v1
Checksum:i6845F095880B8156
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002821 Genomic DNA. Translation: AEI03662.1.
RefSeqiWP_012562601.1. NC_017538.1.
YP_005951543.1. NC_017538.1.

Genome annotation databases

EnsemblBacteriaiAEI03662; AEI03662; OCA4_c25430.
GeneIDi12542373.
KEGGioco:OCA4_c25430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002821 Genomic DNA. Translation: AEI03662.1 .
RefSeqi WP_012562601.1. NC_017538.1.
YP_005951543.1. NC_017538.1.

3D structure databases

ProteinModelPortali F8BKC8.
SMRi F8BKC8. Positions 3-403.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI03662 ; AEI03662 ; OCA4_c25430 .
GeneIDi 12542373.
KEGGi oco:OCA4_c25430.

Phylogenomic databases

KOi K00031.
OMAi KNTIMKV.

Enzyme and pathway databases

BioCyci OCAR1031710:GLI1-2543-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequences of the chemolithoautotrophic Oligotropha carboxidovorans strains OM4 and OM5."
    Volland S., Rachinger M., Strittmatter A., Daniel R., Gottschalk G., Meyer O.
    J. Bacteriol. 193:5043-5043(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OM4Imported.

Entry informationi

Entry nameiF8BKC8_OLICM
AccessioniPrimary (citable) accession number: F8BKC8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 26, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3