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F8BKC8

- F8BKC8_OLICM

UniProt

F8BKC8 - F8BKC8_OLICM

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Oligotropha carboxidovorans (strain OM4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei210 – 2101Critical for catalysisUniRule annotation
    Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
    Binding sitei258 – 2581NADPUniRule annotation
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
    Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi308 – 3136NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciOCAR1031710:GLI1-2543-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:OCA4_c25430Imported
    OrganismiOligotropha carboxidovorans (strain OM4)Imported
    Taxonomic identifieri1031710 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeOligotropha
    ProteomesiUP000000487: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliF8BKC8.
    SMRiF8BKC8. Positions 3-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OMAiKNTIMKV.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8BKC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVANPV VELDGDEMTR IIWQYIKDKL IHPFLDVNLE YYDLGMEHRD    50
    KTNDQVTIDA ANAIKKHGVG VKCATITPDE ARVKEFNLKE MWKSPNGTIR 100
    NILGGVIFRE PIICKNVPRL VPGWNKPIII GRHAFGDQYR ATDFKFPGKG 150
    TLTMKFVGED GSVIEKEVFK SPGAGVAMGM YNLDDSIKDF ARASFNYGLS 200
    RGYPVYLSTK NTILKVYDGR FKDIFQEIYG AEFKKEFEAK GLTYEHRLID 250
    DMVASALKWS GGYVWACKNY DGDVQSDTVA QGYGSLGLMT SVLLTPDGKT 300
    VEAEAAHGTV TRHYREHQKG KETSTNSIAS IFAWTQGLAH RAKLDNNEAL 350
    AKFAKTLERV CVETVESGSM TKDLALLVGP DQKWLSTTGF LDKVAENLTK 400
    AMATA 405
    Length:405
    Mass (Da):45,091
    Last modified:September 21, 2011 - v1
    Checksum:i6845F095880B8156
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002821 Genomic DNA. Translation: AEI03662.1.
    RefSeqiWP_012562601.1. NC_017538.1.
    YP_005951543.1. NC_017538.1.

    Genome annotation databases

    EnsemblBacteriaiAEI03662; AEI03662; OCA4_c25430.
    GeneIDi12542373.
    KEGGioco:OCA4_c25430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002821 Genomic DNA. Translation: AEI03662.1 .
    RefSeqi WP_012562601.1. NC_017538.1.
    YP_005951543.1. NC_017538.1.

    3D structure databases

    ProteinModelPortali F8BKC8.
    SMRi F8BKC8. Positions 3-403.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEI03662 ; AEI03662 ; OCA4_c25430 .
    GeneIDi 12542373.
    KEGGi oco:OCA4_c25430.

    Phylogenomic databases

    KOi K00031.
    OMAi KNTIMKV.

    Enzyme and pathway databases

    BioCyci OCAR1031710:GLI1-2543-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequences of the chemolithoautotrophic Oligotropha carboxidovorans strains OM4 and OM5."
      Volland S., Rachinger M., Strittmatter A., Daniel R., Gottschalk G., Meyer O.
      J. Bacteriol. 193:5043-5043(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OM4Imported.

    Entry informationi

    Entry nameiF8BKC8_OLICM
    AccessioniPrimary (citable) accession number: F8BKC8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3