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F8BKC8 (F8BKC8_OLICM) Unreviewed, UniProtKB/TrEMBL

Last modified December 11, 2013. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Name:icd EMBL AEI03662.1
Ordered Locus Names:OCA4_c25430 EMBL AEI03662.1
OrganismOligotropha carboxidovorans (strain OM4) [Complete proteome] [HAMAP] EMBL AEI03662.1
Taxonomic identifier1031710 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeOligotropha

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR000108-3 PIRNR PIRNR000108

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding308 – 3136NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2581NADP By similarity PIRSR PIRSR000108-4
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity
Site2101Critical for catalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
F8BKC8 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 6845F095880B8156

FASTA40545,091
        10         20         30         40         50         60 
MAKIKVANPV VELDGDEMTR IIWQYIKDKL IHPFLDVNLE YYDLGMEHRD KTNDQVTIDA 

        70         80         90        100        110        120 
ANAIKKHGVG VKCATITPDE ARVKEFNLKE MWKSPNGTIR NILGGVIFRE PIICKNVPRL 

       130        140        150        160        170        180 
VPGWNKPIII GRHAFGDQYR ATDFKFPGKG TLTMKFVGED GSVIEKEVFK SPGAGVAMGM 

       190        200        210        220        230        240 
YNLDDSIKDF ARASFNYGLS RGYPVYLSTK NTILKVYDGR FKDIFQEIYG AEFKKEFEAK 

       250        260        270        280        290        300 
GLTYEHRLID DMVASALKWS GGYVWACKNY DGDVQSDTVA QGYGSLGLMT SVLLTPDGKT 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYREHQKG KETSTNSIAS IFAWTQGLAH RAKLDNNEAL AKFAKTLERV 

       370        380        390        400 
CVETVESGSM TKDLALLVGP DQKWLSTTGF LDKVAENLTK AMATA 

« Hide

References

[1]"Complete genome sequences of the chemolithoautotrophic Oligotropha carboxidovorans strains OM4 and OM5."
Volland S., Rachinger M., Strittmatter A., Daniel R., Gottschalk G., Meyer O.
J. Bacteriol. 193:5043-5043(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OM4 EMBL AEI03662.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002821 Genomic DNA. Translation: AEI03662.1.
RefSeqYP_005951543.1. NC_017538.1.

3D structure databases

ProteinModelPortalF8BKC8.
SMRF8BKC8. Positions 3-403.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEI03662; AEI03662; OCA4_c25430.
GeneID12542373.
KEGGoco:OCA4_c25430.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.
OMAQHQQGKP.

Enzyme and pathway databases

BioCycOCAR1031710:GLI1-2543-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8BKC8_OLICM
AccessionPrimary (citable) accession number: F8BKC8
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: December 11, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)