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F8BKC8

- F8BKC8_OLICM

UniProt

F8BKC8 - F8BKC8_OLICM

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Protein
Isocitrate dehydrogenase [NADP]
Gene
icd, OCA4_c25430
Organism
Oligotropha carboxidovorans (strain OM4)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarity
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei210 – 2101Critical for catalysis By similarityUniRule annotation
Metal bindingi250 – 2501Magnesium or manganese By similarityUniRule annotation
Binding sitei258 – 2581NADP By similarity
Metal bindingi273 – 2731Magnesium or manganese By similarityUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarity
Nucleotide bindingi308 – 3136NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciOCAR1031710:GLI1-2543-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:OCA4_c25430Imported
OrganismiOligotropha carboxidovorans (strain OM4)Imported
Taxonomic identifieri1031710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeOligotropha
ProteomesiUP000000487: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF8BKC8.
SMRiF8BKC8. Positions 3-403.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.
OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8BKC8-1 [UniParc]FASTAAdd to Basket

« Hide

MAKIKVANPV VELDGDEMTR IIWQYIKDKL IHPFLDVNLE YYDLGMEHRD    50
KTNDQVTIDA ANAIKKHGVG VKCATITPDE ARVKEFNLKE MWKSPNGTIR 100
NILGGVIFRE PIICKNVPRL VPGWNKPIII GRHAFGDQYR ATDFKFPGKG 150
TLTMKFVGED GSVIEKEVFK SPGAGVAMGM YNLDDSIKDF ARASFNYGLS 200
RGYPVYLSTK NTILKVYDGR FKDIFQEIYG AEFKKEFEAK GLTYEHRLID 250
DMVASALKWS GGYVWACKNY DGDVQSDTVA QGYGSLGLMT SVLLTPDGKT 300
VEAEAAHGTV TRHYREHQKG KETSTNSIAS IFAWTQGLAH RAKLDNNEAL 350
AKFAKTLERV CVETVESGSM TKDLALLVGP DQKWLSTTGF LDKVAENLTK 400
AMATA 405
Length:405
Mass (Da):45,091
Last modified:September 21, 2011 - v1
Checksum:i6845F095880B8156
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002821 Genomic DNA. Translation: AEI03662.1.
RefSeqiWP_012562601.1. NC_017538.1.
YP_005951543.1. NC_017538.1.

Genome annotation databases

EnsemblBacteriaiAEI03662; AEI03662; OCA4_c25430.
GeneIDi12542373.
KEGGioco:OCA4_c25430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002821 Genomic DNA. Translation: AEI03662.1 .
RefSeqi WP_012562601.1. NC_017538.1.
YP_005951543.1. NC_017538.1.

3D structure databases

ProteinModelPortali F8BKC8.
SMRi F8BKC8. Positions 3-403.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI03662 ; AEI03662 ; OCA4_c25430 .
GeneIDi 12542373.
KEGGi oco:OCA4_c25430.

Phylogenomic databases

KOi K00031.
OMAi KNTIMKV.

Enzyme and pathway databases

BioCyci OCAR1031710:GLI1-2543-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequences of the chemolithoautotrophic Oligotropha carboxidovorans strains OM4 and OM5."
    Volland S., Rachinger M., Strittmatter A., Daniel R., Gottschalk G., Meyer O.
    J. Bacteriol. 193:5043-5043(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OM4Imported.

Entry informationi

Entry nameiF8BKC8_OLICM
AccessioniPrimary (citable) accession number: F8BKC8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3
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