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Protein

Isocitrate dehydrogenase [NADP]

Gene

citC

Organism
Listeria monocytogenes serotype 4a (strain M7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 magnesium or manganese ion per subunit.
  • Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciLMON1030009:GLFW-1674-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:citCImported
Ordered Locus Names:LMM7_1652Imported
OrganismiListeria monocytogenes serotype 4a (strain M7)Imported
Taxonomic identifieri1030009 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000486: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8BB62-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQKIQVENG VLKTPNNPVI PFIEGDGTGP DIWAAAKRVL DAAVKKAYNG
60 70 80 90 100
EKEIAWKEVL AGEKAFKQTG EWLPQATLDT IDEYLIAIKG PLTTPIGGGI
110 120 130 140 150
RSLNVALRQE LDLYVCLRPV RYFKGVPSPV KRPEDTDMVI FRENTEDIYA
160 170 180 190 200
GIEFKEGSVE SKKLIDFLKS EFGVDKIRFP ETSGIGIKPI SKEGTERLVR
210 220 230 240 250
SAIEYTIKEG RKSLTLVHKG NIMKFTEGAF KNWGYDLCER EYGDKVFTWN
260 270 280 290 300
EYDRIKEAEG TEVADAKQKE ALAAGKILVK DSIADIFLQQ ILTRPAEFDV
310 320 330 340 350
VATMNLNGDY ISDALAAQVG GIGIAPGANI NYLTGHAIFE ATHGTAPKYA
360 370 380 390 400
GLDKVNPSSV ILSGTLLLEH IGWGEAAALI NQSMEKTIAA KTVTYDFARL
410 420
MDGATEVKCS EFADELIKNF
Length:420
Mass (Da):46,178
Last modified:September 21, 2011 - v1
Checksum:i46CF5C8D72C65F4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002816 Genomic DNA. Translation: AEH92657.1.
RefSeqiWP_012581261.1. NC_017537.1.
YP_005947715.1. NC_017537.1.

Genome annotation databases

EnsemblBacteriaiAEH92657; AEH92657; LMM7_1652.
GeneIDi12538441.
KEGGilmq:LMM7_1652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002816 Genomic DNA. Translation: AEH92657.1.
RefSeqiWP_012581261.1. NC_017537.1.
YP_005947715.1. NC_017537.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEH92657; AEH92657; LMM7_1652.
GeneIDi12538441.
KEGGilmq:LMM7_1652.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciLMON1030009:GLFW-1674-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nonpathogenic Listeria monocytogenes serovar 4a strain M7."
    Chen J., Xia Y., Cheng C., Fang C., Shan Y., Jin G., Fang W.
    J. Bacteriol. 193:5019-5020(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M7Imported.

Entry informationi

Entry nameiF8BB62_LISMM
AccessioniPrimary (citable) accession number: F8BB62
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 4, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.